The relationship between mitochondrial function and walking performance in older adults with a wide range of physical function.

Age related declines in walking performance may be partly attributable to skeletal muscle mitochondrial dysfunction as mitochondria produce over 90% of ATP needed for movement and the capacity for oxidative phosphorylation decreases with age. Participants were from two studies: an ancillary to the Lifestyle Interventions and Independence for Elders (LIFE) Study (n=33), which recruited lower functioning participants (Short Physical Performance Battery [SPPB], 7.8±1.2), and the Study of Energy and Aging-Pilot (SEA, n=29), which enrolled higher functioning (SPPB, 10.8±1.4). Physical activity was measured objectively using the Actigraph accelerometer (LIFE) and SenseWear Pro armband (SEA). Phosphocreatine recovery following muscle contraction of the quadriceps was measured using (31)P magnetic resonance spectroscopy and ATPmax (mM ATP/s) was calculated. Walking performance was defined as time (s) to walk 400m at a usual-pace. The cross-sectional association between mitochondrial function and walking performance was assessed using multivariable linear regression. Participants were 77.6±5.3years, 64.2% female and 67.2% white. ATPmax was similar in LIFE vs. SEA (0.52±0.14 vs. 0.55±0.14, p=0.31), despite different function and activity levels (1.6±2.2 vs.77.4±73.3min of moderate activity/day, p<0.01). Higher ATPmax was related to faster walk-time in SEA (r(2)=0.19, p=0.02,); but not the LIFE (r(2)<0.01, p=0.74) cohort. Mitochondrial function was associated with walking performance in higher functioning, active older adults, but not lower functioning, sedentary older adults

Skeletal Muscle Mitochondrial Function and Fatigability in Older Adults.

Fatigability increases while the capacity for mitochondrial energy production tends to decrease significantly with age. Thus, diminished mitochondrial function may contribute to higher levels of fatigability in older adults. The relationship between fatigability and skeletal muscle mitochondrial function was examined in 30 participants aged 78.5 ± 5.0 years (47% female, 93% white), with a body mass index of 25.9 ± 2.7 kg/m(2) and usual gait-speed of 1.2 ± 0.2 m/s. Fatigability was defined using rating of perceived exertion (6-20 point Borg scale) after a 5-minute treadmill walk at 0.72 m/s. Phosphocreatine recovery in the quadriceps was measured using (31)P magnetic resonance spectroscopy and images of the quadriceps were captured to calculate quadriceps volume. ATPmax (mM ATP/s) and oxidative capacity of the quadriceps (ATPmax·Quadriceps volume) were calculated. Peak aerobic capacity (VO2peak) was measured using a modified Balke protocol. ATPmax·Quadriceps volume was associated with VO2peak and was 162.61mM ATP·mL/s lower (p = .03) in those with high (rating of perceived exertion ≥10) versus low (rating of perceived exertion ≤9) fatigability. Participants with high fatigability required a significantly higher proportion of VO2peak to walk at 0.72 m/s compared with those with low fatigability (58.7 ± 19.4% vs 44.9 ± 13.2%, p < .05). After adjustment for age and sex, higher ATPmax was associated with lower odds of having high fatigability (odds ratio: 0.34, 95% CI: 0.11-1.01, p = .05). Lower capacity for oxidative phosphorylation in the quadriceps, perhaps by contributing to lower VO2peak, is associated with higher fatigability in older adults

Discovery of a multiply lensed submillimeter galaxy in early HerMES Herschel/SPIRE data

‘In these times, during the rise in the popularity of institutional repositories, the Society does not forbid authors from depositing their work in such repositories. However, the AAS regards the deposit of scholarly work in such repositories to be a decision of the individual scholar, as long as the individual's actions respect the diligence of the journals and their reviewers.’ Original article can be found at: http://iopscience.iop.org/ Copyright American Astronomical SocietyWe report the discovery of a bright (f (250 μm)>400 mJy), multiply lensed submillimeter galaxy HERMES J105751.1+573027 in Herschel/SPIRE Science Demonstration Phase data from the HerMES project. Interferometric 880 μm Submillimeter Array observations resolve at least four images with a large separation of ∼9″. A high-resolution adaptive optics Kp image with Keck/NIRC2 clearly shows strong lensing arcs. Follow-up spectroscopy gives a redshift of z = 2.9575, and the lensing model gives a total magnification of μ ∼ 11 ± 1. The large image separation allows us to study the multi-wavelength spectral energy distribution (SED) of the lensed source unobscured by the central lensing mass. The far-IR/millimeter-wave SED is well described by a modified blackbody fit with an unusually warm dust temperature, 88 ± 3 K. We derive a lensing-corrected total IR luminosity of (1.43 ± 0.09) × 1013 L⊙, implying a star formation rate of ∼2500 M⊙ yr-1. However, models primarily developed from brighter galaxies selected at longer wavelengths are a poor fit to the full optical-to-millimeter SED. A number of other strongly lensed systems have already been discovered in early Herschel data, and many more are expected as additional data are collected.Peer reviewe