T-cell mediated inflammatory pathway in osteoarthritis

AbstractOsteoarthritis (OA) is not caused by a simple consequence of aging and cartilage degradation. Based on the conventional paradigm, OA has been considered a degenerative joint disorder. However, the dominant clinical symptom has been characterized by a non-infectious chronic inflammatory condition with infiltration of inflammatory cells in the synovial tissue or synovial fluid, especially in the early stage of the disease. The inflammatory process appeared to develop degeneration of chondrocytes and/or formation of osteophytes. Immunohistochemical staining of synovial tissue with OA in the early stage, suggests the presence of T-cell infiltration in the perivascular area, some of which were CD4 positive T cells. Among the T cells, we identified the clonality of restricted TCR usage of Vβ chain by single strand conformation polymorphism (SSCP) method on T-cell repertoire. Therefore we address the immune response in primary OA

Evolution of Holographic Entanglement Entropy after Thermal and Electromagnetic Quenches

We study the evolution and scaling of the entanglement entropy after two types of quenches for a 2+1 field theory, using holographic techniques. We study a thermal quench, dual to the addition of a shell of uncharged matter to four dimensional Anti-de Sitter (AdS_4) spacetime, and study the subsequent formation of a Schwarzschild black hole. We also study an electromagnetic quench, dual to the addition of a shell of charged sources to AdS_4, following the subsequent formation of an extremal dyonic black hole. In these backgrounds we consider the entanglement entropy of two types of geometries, the infinite strip and the round disc, and find distinct behavior for each. Some of our findings naturally supply results analogous to observations made in the literature for lower dimensions, but we also uncover several new phenomena, such as (in some cases) a discontinuity in the time derivative of the entanglement entropy as it nears saturation, and for the electromagnetic quench, a logarithmic growth in the entanglement entropy with time for both the disc and strip, before settling to saturation.Comment: 30 pages, 19 figures. Corrected typos and added some discussion. To appear in New J. Phy