Protein nanotechnology

Cite this entry as: Yaradoddi J.S., Kontro M.H., Ganachari S.V., Sulochana M.B., Agsar D. (2019) Protein Nanotechnology. In: Martínez L., Kharissova O., Kharisov B. (eds) Handbook of Ecomaterials. Springer, Cham Publisher Name: Springer, Cham DOI: https://doi.org/10.1007/978-3-319-68255-6_192 Print ISBN: 978-3-319-68254-9 Online ISBN: 978-3-319-68255-6 First Online: 14 February 2019Medical management should be well-preserved; in particular, a fast, easy, and cheap diagnosis. Sometimes, a RNA and DNA nanobio-based diagnostic may not provide precise data with regard to specific disorders. Therefore, some quantifiable protein information and molecular folding are required for the analysis of such disorders. Proteins at minute concentrations are typically undetectable under normal circumstances nowadays, and can be measured and quantified using protein nanotechnology methods. On the other hand, protein machinery carry out tasks that are unsafe for cell behavior, comprising DNA duplication, intracellular carriage, ion pumps, and cellular motility. They have changed with unbelievable multiplicity, precision, efficacy, and a substantial number of studies in contemporary biology have been intended to expose the vital mechanisms or processes of their primary function. This chapter also emphasizes the recent developments in protein nanotechnology, with a special focus on molecular cytoskeletal motors, dyneins, myosins, and kinesins. They constitute a subcategory of protein machineries; they have distinguished properties and are able to convert biochemical energy to work automatically.Peer reviewe

Biopolymer‐based Carriers for DNA Vaccine Design

Abstract: Over the last 30 years, genetically engineered DNA has been tested as novel vaccination strategy against various diseases, including human immunodeficiency virus (HIV), hepatitis B, several parasites, and cancers. However, the clinical breakthrough of the technique is confined by the low transfection efficacy and immunogenicity of the employed vaccines. Therefore, carrier materials were designed to prevent the rapid degradation and systemic clearance of DNA in the body. In this context, biopolymers are a particularly promising DNA vaccine carrier platform due to their beneficial biochemical and physical characteristics, including biocompatibility, stability, and low toxicity. This article reviews the applications, fabrication, and modification of biopolymers as carrier medium for genetic vaccines