341 research outputs found
Electron distribution and intracluster reaction in [Nan(CS2)2]? negative ion clusters
科研費報告書収録論文(課題番号:15350003・基盤研究(B)(2)・15~16/研究代表者:美齊津, 文典/イオンドリフトチューブ法による異性体分離分光のクラスター内反応生物への適用
Microcantilever Studies of Angular Field Dependence of Vortex Dynamics in BSCCO
Using a nanogram-sized single crystal of BSCCO attached to a microcantilever
we demonstrate in a direct way that in magnetic fields nearly parallel to the
{\it ab} plane the magnetic field penetrates the sample in the form of
Josephson vortices rather than in the form of a tilted vortex lattice. We
further investigate the relation between the Josephson vortices and the pancake
vortices generated by the perpendicular field component.Comment: 5 pages, 8 figure
The Reliability of Parafoveal Cone Density Measurements
Background Adaptive optics scanning light ophthalmoscopy (AOSLO) enables direct visualisation of the cone mosaic, with metrics such as cone density and cell spacing used to assess the integrity or health of the mosaic. Here we examined the interobserver and inter-instrument reliability of cone density measurements.
Methods For the interobserver reliability study, 30 subjects with no vision-limiting pathology were imaged. Three image sequences were acquired at a single parafoveal location and aligned to ensure that the three images were from the same retinal location. Ten observers used a semiautomated algorithm to identify the cones in each image, and this was repeated three times for each image. To assess inter-instrument reliability, 20 subjects were imaged at eight parafoveal locations on one AOSLO, followed by the same set of locations on the second AOSLO. A single observer manually aligned the pairs of images and used the semiautomated algorithm to identify the cones in each image.
Results Based on a factorial study design model and a variance components model, the interobserver study\u27s largest contribution to variability was the subject (95.72%) while the observer\u27s contribution was only 1.03%. For the inter-instrument study, an average cone density intraclass correlation coefficient (ICC) of between 0.931 and 0.975 was calculated.
Conclusions With the AOSLOs used here, reliable cone density measurements can be obtained between observers and between instruments. Additional work is needed to determine how these results vary with differences in image quality
Kosterlitz-Thouless transition in three-state mixed Potts ferro-antiferromagnets
We study three-state Potts spins on a square lattice, in which all bonds are
ferromagnetic along one of the lattice directions, and antiferromagnetic along
the other. Numerical transfer-matrix are used, on infinite strips of width
sites, . Based on the analysis of the ratio of scaled mass
gaps (inverse correlation lengths) and scaled domain-wall free energies, we
provide strong evidence that a critical (Kosterlitz-Thouless) phase is present,
whose upper limit is, in our best estimate, . From analysis
of the (extremely anisotropic) nature of excitations below , we argue that
the critical phase extends all the way down to T=0. While domain walls parallel
to the ferromagnetic direction are soft for the whole extent of the critical
phase, those along the antiferromagnetic direction seem to undergo a softening
transition at a finite temperature. Assuming a bulk correlation length varying,
for , as , , we attempt finite-size scaling plots of our finite-width
correlation lengths. Our best results are for . We propose a
scenario in which such inconsistency is attributed to the extreme narrowness of
the critical region.Comment: 11 pages, 6 .eps figures, LaTeX with IoP macros, to be published in J
Phys
Thermoelastic Damping in Micro- and Nano-Mechanical Systems
The importance of thermoelastic damping as a fundamental dissipation
mechanism for small-scale mechanical resonators is evaluated in light of recent
efforts to design high-Q micrometer- and nanometer-scale electro-mechanical
systems (MEMS and NEMS). The equations of linear thermoelasticity are used to
give a simple derivation for thermoelastic damping of small flexural vibrations
in thin beams. It is shown that Zener's well-known approximation by a
Lorentzian with a single thermal relaxation time slightly deviates from the
exact expression.Comment: 10 pages. Submitted to Phys. Rev.
A microchip optomechanical accelerometer
The monitoring of accelerations is essential for a variety of applications
ranging from inertial navigation to consumer electronics. The basic operation
principle of an accelerometer is to measure the displacement of a flexibly
mounted test mass; sensitive displacement measurement can be realized using
capacitive, piezo-electric, tunnel-current, or optical methods. While optical
readout provides superior displacement resolution and resilience to
electromagnetic interference, current optical accelerometers either do not
allow for chip-scale integration or require bulky test masses. Here we
demonstrate an optomechanical accelerometer that employs ultra-sensitive
all-optical displacement read-out using a planar photonic crystal cavity
monolithically integrated with a nano-tethered test mass of high mechanical
Q-factor. This device architecture allows for full on-chip integration and
achieves a broadband acceleration resolution of 10 \mu g/rt-Hz, a bandwidth
greater than 20 kHz, and a dynamic range of 50 dB with sub-milliwatt optical
power requirements. Moreover, the nano-gram test masses used here allow for
optomechanical back-action in the form of cooling or the optical spring effect,
setting the stage for a new class of motional sensors.Comment: 16 pages, 9 figure
Minimization of phonon-tunneling dissipation in mechanical resonators
Micro- and nanoscale mechanical resonators have recently emerged as
ubiquitous devices for use in advanced technological applications, for example
in mobile communications and inertial sensors, and as novel tools for
fundamental scientific endeavors. Their performance is in many cases limited by
the deleterious effects of mechanical damping. Here, we report a significant
advancement towards understanding and controlling support-induced losses in
generic mechanical resonators. We begin by introducing an efficient numerical
solver, based on the "phonon-tunneling" approach, capable of predicting the
design-limited damping of high-quality mechanical resonators. Further, through
careful device engineering, we isolate support-induced losses and perform the
first rigorous experimental test of the strong geometric dependence of this
loss mechanism. Our results are in excellent agreement with theory,
demonstrating the predictive power of our approach. In combination with recent
progress on complementary dissipation mechanisms, our phonon-tunneling solver
represents a major step towards accurate prediction of the mechanical quality
factor.Comment: 12 pages, 4 figure
Therapeutic limitations in tumor-specific CD8+ memory T cell engraftment
BACKGROUND: Adoptive immunotherapy with cytotoxic T lymphocytes (CTL) represents an alternative approach to treating solid tumors. Ideally, this would confer long-term protection against tumor. We previously demonstrated that in vitro-generated tumor-specific CTL from the ovalbumin (OVA)-specific OT-I T cell receptor transgenic mouse persisted long after adoptive transfer as memory T cells. When recipient mice were challenged with the OVA-expressing E.G7 thymoma, tumor growth was delayed and sometimes prevented. The reasons for therapeutic failures were not clear. METHODS: OT-I CTL were adoptively transferred to C57BL/6 mice 21 – 28 days prior to tumor challenge. At this time, the donor cells had the phenotypical and functional characteristics of memory CD8+ T cells. Recipients which developed tumor despite adoptive immunotherapy were analyzed to evaluate the reason(s) for therapeutic failure. RESULTS: Dose-response studies demonstrated that the degree of tumor protection was directly proportional to the number of OT-I CTL adoptively transferred. At a low dose of OT-I CTL, therapeutic failure was attributed to insufficient numbers of OT-I T cells that persisted in vivo, rather than mechanisms that actively suppressed or anergized the OT-I T cells. In recipients of high numbers of OT-I CTL, the E.G7 tumor that developed was shown to be resistant to fresh OT-I CTL when examined ex vivo. Furthermore, these same tumor cells no longer secreted a detectable level of OVA. In this case, resistance to immunotherapy was secondary to selection of clones of E.G7 that expressed a lower level of tumor antigen. CONCLUSIONS: Memory engraftment with tumor-specific CTL provides long-term protection against tumor. However, there are several limitations to this immunotherapeutic strategy, especially when targeting a single antigen. This study illustrates the importance of administering large numbers of effectors to engraft sufficiently efficacious immunologic memory. It also demonstrates the importance of targeting several antigens when developing vaccine strategies for cancer
The Importance of Edge Effects on the Intrinsic Loss Mechanisms of Graphene Nanoresonators
We utilize classical molecular dynamics simulations to investigate the
intrinsic loss mechanisms of monolayer graphene nanoresonators undergoing
flexural oscillations. We find that spurious edge modes of vibration, which
arise not due to externally applied stresses but intrinsically due to the
different vibrational properties of edge atoms, are the dominant intrinsic loss
mechanism that reduces the Q-factors. We additionally find that while hydrogen
passivation of the free edges is ineffective in reducing the spurious edge
modes, fixing the free edges is critical to removing the spurious edge-induced
vibrational states. Our atomistic simulations also show that the Q-factor
degrades inversely proportional to temperature; furthermore, we also
demonstrate that the intrinsic losses can be reduced significantly across a
range of operating temperatures through the application of tensile mechanical
strain.Comment: 15 pages, 5 figures. Accepted for publication in Nano Letter
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