1,856 research outputs found
Attentional suppression of activity in the human visual cortex
We have used fMRI to examine the nature of the changes that occur in the human visual cortex when an observer attends to a particular location in the visual image. Previous studies have shown that the magnitude of the response to a visual stimulus is increased when the observer attends to the stimulus. We show that, in addition, attention to a particular location results in a widespread suppression of activity levels at all other locations. This suggests that a key mechanism of attentional modulation may be that spontaneous (baseline) levels of neural activity are adjusted in a position-dependent manner across the entire visual field
Spatiotemporal Frequency and Direction Sensitivities of Human Visual Areas Measured Using fMRI
Using functional magnetic resonance imaging (fMRI) we have studied the variation in response magnitude, in each visual area (V1–V5), as a function of spatial frequency (SF), temporal frequency (TF) and unidirectional motion versus counterphase flicker. Each visual area was identified in each subject using a combination of retinotopic mapping fMRI and cortical flattening techniques. A drifting (or counterphasing) sinusoidal grating was used as the stimulus in a study in which we parametrically varied SF between 0.4 and 7 cycles/degree and TF between 0 and 18 Hz. For each experiment we constructed fMRI amplitude tuning curves, averaged across subjects, for each visual area. The tuning curves that resulted are consistent with the known physiological properties of cells in the corresponding macaque visual areas, previous functional imaging studies, and in the case of V1, the psychophysically determined contrast sensitivity functions for spatial and temporal frequency. In the case of V3A, the SF tuning functions obtained were more similar to those found in single cell studies of macaque V3 rather than macaque V3A. All areas showed at least a moderate preference for directed versus counterphasing motion with V5 showing the largest preference. Visual areas V1, V2, V3, and V3A showed more direction sensitivity at low spatial frequencies, while VP, V4, and V5 had the highest drifting versus counterphasing ratios for higher spatial frequencies
Effect of eye movements on the magnitude of functional magnetic resonance imaging responses in extrastriate cortex during visual motion perception
We have studied the effects of pursuit eye movements on the functional magnetic resonance imaging (fMRI) responses in extrastriate visual areas during visual motion perception. Echoplanar imaging of 10–12 image planes through visual cortex was acquired in nine subjects while they viewed sequences of random-dot motion. Images obtained during stimulation periods were compared with baseline images, where subjects viewed a blank field. In a subsidiary experiment, responses to moving dots, viewed under conditions of fixation or pursuit, were compared with those evoked by static dots. Eye movements were recorded with MR-compatible electro-oculographic (EOG) electrodes. Our findings show an enhanced level of activation (as indexed by blood-oxygen level-dependent contrast) during pursuit compared with fixation in two extrastriate areas. The results support earlier findings on a motion-specific area in lateral occipitotemporal cortex (human V5). They also point to a further site of activation in a region approximately 12 mm dorsal of V5. The fMRI response in V5 during pursuit is significantly enhanced. This increased response may represent additional processing demands required for the control of eye movements
fMRI Response During Visual Motion Stimulation in Patients with Late Whiplash Syndrome
After whiplash trauma, up to one fourth of patients develop chronic symptoms including head and neck pain and cognitive disturbances. Resting perfusion single-pho ton-emission computed tomography (SPECT) found decreased temporoparietooccipi tal tracer uptake among these long-term symptomatic patients with late whiplash syn drome. As MT/MST (V5/V5a) are located in that area, this study addressed the question whether these patients show impairments in visual motion perception. We examined five symptomatic patients with late whiplash syndrome, five asymptomatic patients after whiplash trauma, and a control group of seven volunteers without the history of trauma. Tests for visual motion perception and functional magnetic resonance imaging (fMRI) measurements during visual motion stimulation were performed. Symptomatic patients showed a significant reduction in their ability to perceive coherent visual motion com pared with controls, whereas the asymptomatic patients did not show this effect. fMRI activation was similar during random dot motion in all three groups, but was signifi cantly decreased during coherent dot motion in the symptomatic patients compared with the other two groups. Reduced psychophysical motion performance and reduced fMRI responses in symptomatic patients with late whiplash syndrome both point to a functional impairment in cortical areas sensitive to coherent motion. Larger studies are needed to confirm these clinical and functional imaging results to provide a possible additional diagnostic criterion for the evaluation of patients with late whiplash syndrome
Experimentelle Überprüfung einer evolutionstheoretischen Erklärung von Schlafplatzpräferenzen des Menschen
Obwohl Menschen einen groĂźen Teil des Tages an ihrem
Schlafplatz verbringen, gibt es kaum experimentelle und
theoriegeleitete Studien zur Schlafplatzwahl des Menschen.
Da der Mensch im Schlaf relativ schutzlos gegenüber Angreifern ist und eine passende Wahl der Schlafumgebung Schutz und damit höhere Überlebenschancen bietet, wird die Schlafplatzwahl aus evolutionärer Perspektive untersucht.
Es wird ein Evolutionsbedingter Psychologischer Mechanismus (EPM) zur Schlafplatzwahl postuliert und daraus abgeleitete Hypothesen überprüft: Ein Schlafplatz sollte so gewählt werden, dass er schnelle Reaktionen auf Angreifer ermöglicht. Daher sollte (1) vom Bett aus die Tür im Blickfeld sein, (2) das Bett in deutlicher Weise von der Tür abgerückt sein und (3) bevorzugt in die Zimmerhälfte gestellt werden, in die sich die Tür öffnet. Eine Studie mit 138 Probanden, die Möbel auf experimentell manipulierten Grundrissen anrichten, kann diese Hypothesen bestätigen
Estimating Receptive Field Size from fMRI Data in Human Striate and Extrastriate Visual Cortex
Functional magnetic resonance imaging (fMRI) was used to estimate the average receptive field sizes of neurons in each of several striate and extrastriate visual areas of the human cerebral cortex. The boundaries of the visual areas were determined by retinotopic mapping procedures and were visualized on flattened representations of the occipital cortex. Estimates of receptive field size were derived from the temporal duration of the functional activation at each cortical location as a visual stimulus passed through the receptive fields represented at that location. Receptive fields are smallest in the primary visual cortex (V1). They are larger in V2, larger again in V3/VP and largest of all in areas V3A and V4. In all these areas, receptive fields increase in size with increasing stimulus eccentricity. The results are qualitatively in line with those obtained by others in macaque monkeys using neurophysiological methods
Impairment in preattentive visual processing in patients with Parkinson's disease
We explored the possibility of whether preattentive visual processing is impaired in Parkinson's disease. With this aim, visual discrimination thresholds for orientation texture stimuli were determined in two separate measurement sessions in 16 patients with idiopathic Parkinson's disease. The results were compared with those of 16 control subjects age-matched and 16 young healthy volunteers. Discrimination thresholds were measured in a four-alternative spatial forced-choice paradigm, in which subjects judged the location of a target embedded in a background of distractors. Four different stimulus configurations were employed: (i) a group of vertical targets among horizontal distractors (`vertical line targets'); (ii) targets with varying levels of orientation difference on a background of spatially filtered vertically oriented noise (`Gaussian filtered noise'); (iii) one `L' among 43 `+' signs (`texton'), all of which assess preattentive visual processing; and (iv) control condition, of one `L' among 43 `T' distractors (`non-texton' search target), which reflects attentive visual processing. In two of the preattentive tasks (filtered noise and texton), patients with Parkinson's disease required significantly greater orientation differences and longer stimulus durations, respectively. In contrast, their performance in the vertical line target and non-texton search target was comparable to that of the matched control subjects. These differences were more pronounced in the first compared with the second session. Duration of illness and age within the patient group correlated significantly with test performance. In all conditions tested, the young control subjects performed significantly better than the more elderly control group, further indicating an effect of age on this form of visual processing. The results suggest that, in addition to the well documented impairment in retinal processing, idiopathic Parkinson's disease is associated with a deficit in preattentive cortical visual processing
Rare Kaon Decays
The current status of rare kaon decay experiments is reviewed. New limits in
the search for Lepton Flavor Violation are discussed, as are new measurements
of the CKM matrix.Comment: 8 pages, 3 figures, LaTeX, presented at the 3rd International
Conference on B Phyiscs and CP Violation, Taipei December 3-7, 199
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