Radial honeycomb core

Core alleviates many limitations of conventional nacelle construction methods. Radical core, made of metals or nonmetals, is fabricated either by joining nodes and then expanding, or by performing each layer and then joining nodes. Core may also be produced from ribbons or strips with joined nodes or ribbons oriented in longitudinal planes

Xenon ion propulsion for orbit transfer

For more than 30 years, NASA has conducted an ion propulsion program which has resulted in several experimental space flight demonstrations and the development of many supporting technologies. Technologies appropriate for geosynchronous stationkeeping, earth-orbit transfer missions, and interplanetary missions are defined and evaluated. The status of critical ion propulsion system elements is reviewed. Electron bombardment ion thrusters for primary propulsion have evolved to operate on xenon in the 5 to 10 kW power range. Thruster efficiencies of 0.7 and specific impulse values of 4000 s were documented. The baseline thruster currently under development by NASA LeRC includes ring-cusp magnetic field plasma containment and dished two-grid ion optics. Based on past experience and demonstrated simplifications, power processors for these thrusters should have approximately 500 parts, a mass of 40 kg, and an efficiency near 0.94. Thrust vector control, via individual thruster gimbals, is a mature technology. High pressure, gaseous xenon propellant storage and control schemes, using flight qualified hardware, result in propellant tankage fractions between 0.1 and 0.2. In-space and ground integration testing has demonstrated that ion propulsion systems can be successfully integrated with their host spacecraft. Ion propulsion system technologies are mature and can significantly enhance and/or enable a variety of missions in the nation's space propulsion program

Limited Activity Of Miltefosine In Murine Models Of Cryptococcal Meningoencephalitis And Disseminated Cryptococcosis

Miltefosine is an alkyl phosphocholine with good oral bioavailability and in vitro activity against Cryptococcus species that has gained interest as an additional agent for cryptococcal infections. Our objective was to further evaluate the in vivo efficacy of miltefosine in experimental in vivo models of cryptococcal meningoencephalitis and disseminated cryptococcosis. Mice were infected intracranially or intravenously with either C. neoformans USC1597 or H99. Miltefosine treatment (1.8 to 45 mg/kg of body weight orally once daily) began at either 1 h or 1 day postinoculation. Fluconazole (10 mg/kg orally twice daily) or amphotericin B deoxycholate (3 mg/kg intraperitoneally once daily) served as positive controls. In our standard models, miltefosine did not result in significant improvements in survival or reductions in fungal burden against either C. neoformans isolate. There was a trend toward improved survival with miltefosine at 7.2 mg/kg against disseminated cryptococcosis with the H99 strain but only at a low infecting inoculum. In contrast, both fluconazole and amphotericin B significantly improved survival in mice with cryptococcal meningoencephalitis and disseminated cryptococcosis due to USC1597. Amphotericin B also improved survival against both cryptococcal infections caused by H99. Combination therapy with miltefosine demonstrated neither synergy nor antagonism in both models. These results demonstrate limited efficacy of miltefosine and suggest caution with the potential use of this agent for the treatment of C. neoformans infections.Pharmac

QZ Serpentis: A Dwarf Nova with a 2-Hour Orbital Period and an Anomalously Hot, Bright Secondary Star

We present spectroscopy and time-series photometry of the dwarf nova QZ Ser. The spectrum shows a rich absorption line spectrum of type K4 +- 2. K-type secondary stars are generally seen in dwarf novae with orbital periods P-orb around 6 h, but in QZ Ser the absorption radial velocities show an obvious modulation (semi-amplitude 207(5) km/s) at P-orb = 119.752(2) min, much shorter than typical for such a relatively warm and prominent secondary spectrum. The H-alpha emission-line velocity is modulated at the same period and roughly opposite phase. Time-series photometry shows flickering superposed on a modulation with two humps per orbit, consistent with ellipsoidal variation of the secondary's light. QZ Ser is a second example of a relatively short-period dwarf nova with a surprisingly warm secondary. Model calculations suggest that the secondary is strongly enhanced in helium, and had already undergone significant nuclear evolution when mass transfer began. Several sodium absorption features in the secondary spectrum are unusually strong, which may indicate that the present-day surface was the site of CNO-cycle hydrogen burning in the past.Comment: 11 pages, 3 postscript figures, 1 jpeg greyscale figure. Accepted for publication in PAS

The Extended Shapes of Galactic Satellites

We are exploring the extended stellar distributions of Galactic satellite galaxies and globular clusters. For seven objects studied thus far, the observed profile departs from a King function at large r, revealing a ``break population'' of stars. In our sample, the relative density of the ``break'' correlates to the inferred M/L of these objects. We discuss opposing hypotheses for this trend: (1) Higher M/L objects harbor more extended dark matter halos that support secondary, bound, stellar ``halos''. (2) The extended populations around dwarf spheroidals (and some clusters) consist of unbound, extratidal debris from their parent objects, which are undergoing various degrees of tidal disruption. In this scenario, higher M/L ratios reflect higher degrees of virial non-equilibrium in the parent objects, thus invalidating a precept underlying the use of core radial velocities to obtain masses.Comment: 8 pages, including 2 figures Yale Cosmology Workshop: The Shapes of Galaxies and Their Halo

Ion Thruster Development at NASA Lewis Research Center

Recent ion propulsion technology efforts at NASA's Lewis Research Center including development of kW-class xenon ion thrusters, high power xenon and krypton ion thrusters, and power processors are reviewed. Thruster physical characteristics, performance data, life projections, and power processor component technology are summarized. The ion propulsion technology program is structured to address a broad set of mission applications from satellite stationkeeping and repositioning to primary propulsion using solar or nuclear power systems

The kinetics of the reaction of superoxide radical with Fe(III) complexes of EDTA, DETAPAC and HEDTA

AbstractTo gain an understanding of the mechanism by which the hydroxyl free radical can arise in superoxide generating systems and learn how different chelaters of iron can inhibit this reaction, a pulse radiolysis kinetic study of the reaction of O−2 with Fe(III)EDTA, Fe(III)HEDTA and Fe(III)DETAPAC (or DTPA) was undertaken. Superoxide reacts readily with Fe(III)EDTA and Fe(III)HEDTA with a pH-dependent second-order rate constant having values of 1.9 × 106 M−1.s−1 and 7.6 × 105 M−1.s−1 at pH 7, respectively. However, the rate constant for the reaction of O−2 with Fe(III)DETAPAC was found to be much slower, the upper limit for the rate constant being 104 M−1.s−1. These results in conjunction with spin-trapping experiments with Fe(II)EDTA, Fe(II)HEDTA, Fe(II)DETAPAC and H2O2 suggests that DETAPAC inhibits the formation of OH by slowing the reduction of Fe(III) to Fe(II) and not by inhibiting the Fenton reaction