Squeeze-Film Flow in the Presence of a Thin Porous Bed, with Application to the Human Knee Joint

Motivated by the desire for a better understanding of the lubrication of the human knee joint, the squeeze-film flow of a thin layer of Newtonian fluid (representing the synovial fluid) filling the gap between a flat impermeable surface (representing the femoral condyles) and a flat thin porous bed (representing the articular cartilage) coating a stationary flat impermeable surface (representing the tibial plateau) is considered. As the impermeable surface approaches the porous bed under a prescribed constant load all of the fluid is squeezed out of the gap in a finite contact time. In the context of the knee, the size of this contact time suggests that when a person stands still for a short period of time their knees may be fluid lubricated, but that when they stand still for a longer period of time contact between the cartilage-coated surfaces may occur. The fluid particle paths are calculated, and the penetration depths of fluid particles into the porous bed are determined. In the context of the knee, these penetration depths provide a measure of how far into the cartilage nutrients are carried by the synovial fluid, and suggest that when a person stands still nutrients initially in the fluid layer penetrate only a relatively small distance into the cartilage. However, the model also suggests that the cumulative effect of repeated loading and unloading of the knees during physical activity such as walking or running may be sufficient to carry nutrients deep into the cartilage

Power Spectrum Estimators For Large CMB Datasets

Forthcoming high-resolution observations of the Cosmic Microwave Background (CMB) radiation will generate datasets many orders of magnitude larger than have been obtained to date. The size and complexity of such datasets presents a very serious challenge to analysing them with existing or anticipated computers. Here we present an investigation of the currently favored algorithm for obtaining the power spectrum from a sky-temperature map --- the quadratic estimator. We show that, whilst improving on direct evaluation of the likelihood function, current implementations still inherently scale as the equivalent of the cube of the number of pixels or worse, and demonstrate the critical importance of choosing the right implementation for a particular dataset.Comment: 8 pages LATEX, no figures, corrected misaligned columns in table

On the jets, kinks, and spheromaks formed by a planar magnetized coaxial gun

Measurements of the various plasma configurations produced by a planar magnetized coaxial gun provide insight into the magnetic topology evolution resulting from magnetic helicity injection. Important features of the experiments are a very simple coaxial gun design so that all observed geometrical complexity is due to the intrinsic physical dynamics rather than the source shape and use of a fast multiple-frame digital camera which provides direct imaging of topologically complex shapes and dynamics. Three key experimental findings were obtained: (1) formation of an axial collimated jet [Hsu and Bellan, Mon. Not. R. Astron. Soc. 334, 257 (2002)] that is consistent with a magnetohydrodynamic description of astrophysical jets, (2) identification of the kink instability when this jet satisfies the Kruskal-Shafranov limit, and (3) the nonlinear properties of the kink instability providing a conversion of toroidal to poloidal flux as required for spheromak formation by a coaxial magnetized source [Hsu and Bellan, Phys. Rev. Lett. 90, 215002 (2003)]. A new interpretation is proposed for how the n=1 central column instability provides flux amplification during spheromak formation and sustainment, and it is shown that jet collimation can occur within one rotation of the background poloidal field.Comment: Physics of Plasmas (accepted

Resistance and Resignation:Responses to Typecasting in British Acting

This article draws on 38 in-depth interviews with British actors to explore the operation of typecasting. First, we argue that typecasting acts as the key mechanism through which the ‘somatic norm’ is established in British acting. It delivers an oversupply of leading roles for white, male, middle-class actors while ensuring that those who deviate somatically are restricted to largely socially caricatured roles. Second, we focus on the career trajectories of ‘othered’ actors. While they frequently experience acting roles as offensive and discriminatory, we demonstrate how most nonetheless reluctantly accept the terms of their ‘type’ in order to survive and succeed. Third, we focus on the minority who have attempted to challenge their type. Here we find that successful resistance is accomplished by carefully choosing work that subverts the somatic norm. However, the ability to exercise such choice is highly contingent on resources associated with an actor’s class origin

Spores of Clostridium engineered for clinical efficacy and safety cause regression and cure of tumors in vivo.

Spores of some species of the strictly anaerobic bacteria Clostridium naturally target and partially lyse the hypoxic cores of tumors, which tend to be refractory to conventional therapies. The anti-tumor effect can be augmented by engineering strains to convert a non-toxic prodrug into a cytotoxic drug specifically at the tumor site by expressing a prodrug-converting enzyme (PCE). Safe doses of the favored prodrug CB1954 lead to peak concentrations of 6.3 μM in patient sera, but at these concentration(s) known nitroreductase (NTR) PCEs for this prodrug show low activity. Furthermore, efficacious and safe Clostridium strains that stably express a PCE have not been reported. Here we identify a novel nitroreductase from Neisseria meningitidis, NmeNTR, which is able to activate CB1954 at clinically-achievable serum concentrations. An NmeNTR expression cassette, which does not contain an antibiotic resistance marker, was stably localized to the chromosome of Clostridium sporogenes using a new integration method, and the strain was disabled for safety and containment by making it a uracil auxotroph. The efficacy of Clostridium-Directed Enzyme Prodrug Therapy (CDEPT) using this system was demonstrated in a mouse xenograft model of human colon carcinoma. Substantial tumor suppression was achieved, and several animals were cured. These encouraging data suggest that the novel enzyme and strain engineering approach represent a promising platform for the clinical development of CDEPT

A re-analysis of the three-year WMAP temperature power spectrum and likelihood

We analyze the three-year WMAP temperature anisotropy data seeking to confirm the power spectrum and likelihoods published by the WMAP team. We apply five independent implementations of four algorithms to the power spectrum estimation and two implementations to the parameter estimation. Our single most important result is that we broadly confirm the WMAP power spectrum and analysis. Still, we do find two small but potentially important discrepancies: On large angular scales there is a small power excess in the WMAP spectrum (5-10% at l<~30) primarily due to likelihood approximation issues between 13 <= l <~30. On small angular scales there is a systematic difference between the V- and W-band spectra (few percent at l>~300). Recently, the latter discrepancy was explained by Huffenberger et al. (2006) in terms of over-subtraction of unresolved point sources. As far as the low-l bias is concerned, most parameters are affected by a few tenths of a sigma. The most important effect is seen in n_s. For the combination of WMAP, Acbar and BOOMERanG, the significance of n_s =/ 1 drops from ~2.7 sigma to ~2.3 sigma when correcting for this bias. We propose a few simple improvements to the low-l WMAP likelihood code, and introduce two important extensions to the Gibbs sampling method that allows for proper sampling of the low signal-to-noise regime. Finally, we make the products from the Gibbs sampling analysis publically available, thereby providing a fast and simple route to the exact likelihood without the need of expensive matrix inversions.Comment: 14 pages, 7 figures. Accepted for publication in ApJ. Numerical results unchanged, but interpretation sharpened: Likelihood approximation issues at l=13-30 far more important than potential foreground issues at l <= 12. Gibbs products (spectrum and sky samples, and "easy-to-use" likelihood module) available from http://www.astro.uio.no/~hke/ under "Research

Phonon Coherence and New Set of Sidebands in Phonon-Assisted Photoluminescence

We investigate excitonic polaron states comprising a local exciton and phonons in the longitudinal optical (LO) mode by solving the Schr\"{o}dinger equation. We derive an exact expression for the ground state (GS), which includes multi-phonon components with coefficients satisfying the Huang-Rhys factors. The recombination of GS and excited polaron states gives one set of sidebands in photoluminescence (PL): the multi-phonon components in the GS produce the Stokes lines and the zero-phonon components in the excited states produce the anti-Stokes lines. By introducing the mixing of the LO mode and environal phonon modes, the exciton will also couple with the latter, and the resultant polaron states result in another set of phonon sidebands. This set has a zero-phonon line higher and wider than that of the first set due to the tremendous number of the environal modes. The energy spacing between the zero-phonon lines of the first and second sets is proved to be the binding energy of the GS state. The common exciton origin of these two sets can be further verified by a characteristic Fano lineshape induced by the coherence in the mixing of the LO and the environal modes.Comment: 5 pages, 3 figures 1 figure (fig. 1) replaced 1 figure (fig. 2) remove