12,751 research outputs found
McStas and Mantid integration
McStas and Mantid are two well established software frameworks within the
neutron scattering community. McStas has been primarily used for simulating the
neutron transport of instruments, while Mantid has been primarily used for data
reduction. We report here the status of our work done on the interoperability
between the instrument simulation software McStas and the data reduction
software Mantid. This provides a demonstration of how to successfully link
together two software that otherwise have been developed independently, and in
particular here show how this has been achieved for an instrument simulation
software and a data reduction software. This paper will also provide examples
of some of the expected future enhanced analysis that can be achieved from
combining accurate instrument and sample simulations with software for
correcting raw data. In the case of this work for raw data collected at large
scale neutron facilities.Comment: 17 pages, 12 figures, POSTPRINT with proofs of article submitted to
Journal of Neutron Researc
One-Dimensional Theory of the Quantum Hall System
We consider the lowest Landau level on a torus as a function of its
circumference . When , the ground state at general rational
filling fraction is a crystal with a gap--a Tao-Thouless state. For filling
fractions , these states are the limits of Laughlin's or Jain's
wave functions describing the gapped quantum Hall states when .
For the half-filled Landau level, there is a transition to a Fermi sea of
non-interacting neutral dipoles, or rather to a Luttinger liquid modification
thereof, at magnetic lengths. This state is a version of the
Rezayi-Read state, and develops continuously into the state that is believed to
describe the observed metallic phase as . Furthermore, the
effective Landau level structure that emerges within the lowest Landau level
follows from the magnetic symmetries.Comment: 4 pages, 1 figur
Constant net-time headway as key mechanism behind pedestrian flow dynamics
We show that keeping a constant lower limit on the net-time headway is the
key mechanism behind the dynamics of pedestrian streams. There is a large
variety in flow and speed as functions of density for empirical data of
pedestrian streams, obtained from studies in different countries. The net-time
headway however, stays approximately constant over all these different data
sets. By using this fact, we demonstrate how the underlying dynamics of
pedestrian crowds, naturally follows from local interactions. This means that
there is no need to come up with an arbitrary fit function (with arbitrary fit
parameters) as has traditionally been done. Further, by using not only the
average density values, but the variance as well, we show how the recently
reported stop-and-go waves [Helbing et al., Physical Review E, 75, 046109]
emerge when local density variations take values exceeding a certain maximum
global (average) density, which makes pedestrians stop.Comment: 7 pages, 7 figure
X-ray Halos and Large Grains in the Diffuse Interstellar Medium
Recent observations with dust detectors on board the interplanetary
spacecraft Ulysses and Galileo have recorded a substantial flux of large
interstellar grains with radii between 0.25 and 2.0 mu entering the solar
system from the local interstellar cloud. The most commonly used interstellar
grain size distribution is characterized by a a^-3.5 power law in grain radii
a, and extends to a maximum grain radius of 0.25 mu. The extension of the
interstellar grain size distribution to such large radii will have a major
effect on the median grain size, and on the amount of mass needed to be tied up
in dust for a given visual optical depth. It is therefore important to
investigate whether this population of larger dust particles prevails in the
general interstellar medium, or if it is merely a local phenomenon. The
presence of large interstellar grains can be mainly inferred from their effect
on the intensity and radial profiles of scattering halos around X-ray sources.
In this paper we examine the grain size distribution that gives rise to the
X-ray halo around Nova Cygni 1992. The results of our study confirm the need to
extend the interstellar grain size distribution in the direction of this source
to and possibly beyond 2.0 mu. The model that gives the best fit to the halo
data is characterized by: (1) a grain size distribution that follows an a^-3.5
power law up to 0.50 mu, followed by an a^-4.0 extension from 0.50 mu to 2.0
mu; and (2) silicate and graphite (carbon) dust-to-gas mass ratios of 0.0044
and 0.0022, respectively, consistent with solar abundances constraints.
Additional observations of X-ray halos probing other spatial directions are
badly needed to test the general validity of this result.Comment: 17 pages, incl. 1 figure, accepted for publ. by ApJ Letter
Ground state phases of the Half-Filled One-Dimensional Extended Hubbard Model
Using quantum Monte Carlo simulations, results of a strong-coupling
expansion, and Luttinger liquid theory, we determine quantitatively the ground
state phase diagram of the one-dimensional extended Hubbard model with on-site
and nearest-neighbor repulsions U and V. We show that spin frustration
stabilizes a bond-ordered (dimerized) state for U appr. V/2 up to U/t appr. 9,
where t is the nearest-neighbor hopping. The transition from the dimerized
state to the staggered charge-density-wave state for large V/U is continuous
for U up to appr. 5.5 and first-order for higher U.Comment: 4 pages, 4 figure
Improving Assessment of Drug Safety Through Proteomics: Early Detection and Mechanistic Characterization of the Unforeseen Harmful Effects of Torcetrapib.
BackgroundEarly detection of adverse effects of novel therapies and understanding of their mechanisms could improve the safety and efficiency of drug development. We have retrospectively applied large-scale proteomics to blood samples from ILLUMINATE (Investigation of Lipid Level Management to Understand its Impact in Atherosclerotic Events), a trial of torcetrapib (a cholesterol ester transfer protein inhibitor), that involved 15 067 participants at high cardiovascular risk. ILLUMINATE was terminated at a median of 550 days because of significant absolute increases of 1.2% in cardiovascular events and 0.4% in mortality with torcetrapib. The aims of our analysis were to determine whether a proteomic analysis might reveal biological mechanisms responsible for these harmful effects and whether harmful effects of torcetrapib could have been detected early in the ILLUMINATE trial with proteomics.MethodsA nested case-control analysis of paired plasma samples at baseline and at 3 months was performed in 249 participants assigned to torcetrapib plus atorvastatin and 223 participants assigned to atorvastatin only. Within each treatment arm, cases with events were matched to controls 1:1. Main outcomes were a survey of 1129 proteins for discovery of biological pathways altered by torcetrapib and a 9-protein risk score validated to predict myocardial infarction, stroke, heart failure, or death.ResultsPlasma concentrations of 200 proteins changed significantly with torcetrapib. Their pathway analysis revealed unexpected and widespread changes in immune and inflammatory functions, as well as changes in endocrine systems, including in aldosterone function and glycemic control. At baseline, 9-protein risk scores were similar in the 2 treatment arms and higher in participants with subsequent events. At 3 months, the absolute 9-protein derived risk increased in the torcetrapib plus atorvastatin arm compared with the atorvastatin-only arm by 1.08% (P=0.0004). Thirty-seven proteins changed in the direction of increased risk of 49 proteins previously associated with cardiovascular and mortality risk.ConclusionsHeretofore unknown effects of torcetrapib were revealed in immune and inflammatory functions. A protein-based risk score predicted harm from torcetrapib within just 3 months. A protein-based risk assessment embedded within a large proteomic survey may prove to be useful in the evaluation of therapies to prevent harm to patients.Clinical trial registrationURL: https://www.clinicaltrials.gov. Unique identifier: NCT00134264
Numerical Renormalization Group for Impurity Quantum Phase Transitions: Structure of Critical Fixed Points
The numerical renormalization group method is used to investigate zero
temperature phase transitions in quantum impurity systems, in particular in the
particle-hole symmetric soft-gap Anderson model. The model displays two stable
phases whose fixed points can be built up of non-interacting single-particle
states. In contrast, the quantum phase transitions turn out to be described by
interacting fixed points, and their excitations cannot be described in terms of
free particles. We show that the structure of the many-body spectrum of these
critical fixed points can be understood using renormalized perturbation theory
close to certain values of the bath exponents which play the role of critical
dimensions. Contact is made with perturbative renormalization group
calculations for the soft-gap Anderson and Kondo models. A complete description
of the quantum critical many-particle spectra is achieved using suitable
marginal operators; technically this can be understood as epsilon-expansion for
full many-body spectra.Comment: 14 pages, 12 figure
810 nm Light Therapy Improves Axonal Regeneration and Functional Recovery Following Acute Spinal Cord Injury
Detecting metal-rich intermediate-age globular clusters in NGC4570 using K-band photometry
“The original publication is available at www.springerlink.com”. Copyright Springer. DOI: 10.1007/s10509-009-0093-8Globular cluster systems (GCSs) of most early-type galaxies feature two peaks in their optical colour distributions. Blue-peak globular clusters (GCs) are believed to be old and metal-poor, whereas the ages, metallicities, and the origin of the red-peak GCs are still being debated. We obtained deep K-band photometry and combined it with Hubble Space Telescope observations in g and z to yield a full spectral energy distribution from the optical to the near-infrared. This now allows us to break the age–metallicity degeneracy. We used our evolutionary synthesis models galev for star clusters to compute a large grid of models with different metallicities and a wide range of ages. Comparing these models to our observations revealed a large population of intermediate-age (1–3 Gyr) and metal-rich (≈solar-metallicity) GCs, that will give us further insights into the formation history of this galaxy.Peer reviewe
Multi-critical point in a diluted bilayer Heisenberg quantum antiferromagnet
The S=1/2 Heisenberg bilayer antiferromagnet with randomly removed
inter-layer dimers is studied using quantum Monte Carlo simulations. A
zero-temperature multi-critical point (p*,g*) at the classical percolation
density p=p* and inter-layer coupling g* approximately 0.16 is demonstrated.
The quantum critical exponents of the percolating cluster are determined using
finite-size scaling. It is argued that the associated finite-temperature
quantum critical regime extends to zero inter-layer coupling and could be
relevant for antiferromagnetic cuprates doped with non-magnetic impurities.Comment: 4 pages, 6 figures. v2: only minor changes; accepted for publication
in Phys. Rev. Let
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