1,688 research outputs found

    PDB33 THE EFFICACY OF INSULIN GLARGINE COMPARED TO OTHER INJECTABLE THERAPIES-A META-ANALYSIS OF CLINICAL OUTCOMES IN INSULIN NAÏVE TYPE 2 DIABETES PATIENTS

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    EVALUATING MOVEMENT CONSISTENCY IN WHEELCHAIR PROPULSION USING FLOQUET MULTIPLIERS AND QUATERNIONS

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    Wheelchair users may develop repetitive stress injuries that are associated with the wheelchair-stroke. Evaluating if a stroke pattern is consistent may reveal the existence of a possible injury. However, there is no standardized method to evaluate the stability of the wheelchair-stroke. The purpose of this paper was to develop a method to measure movement consistency during manual wheelchair propulsion without the need of normreferenced tests. The method is based (a) on the Floquet theory, (b) on Poincaré, and (c) on quaternion transformations. The method was evaluated with experimental data and the results showed that the method is sensitive enough to identify instabilities in the wheelchair stroke cycle. Furthermore, the method can be generalized to study other aspects of human motor control

    Aligning Paradigms, Standards, and Assessment: A Higher-Education Application for Instruction in Science and Mathematics

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    Disciplines of science and mathematics are essential for 21st century life and progress of our nation. To strengthen the effectiveness of education in the state of Georgia and to address emerging and enduring issues in 21st century life, the state adopted Georgia Performance Standards. To meet the standards of science and mathematics in Georgia classrooms, programs of teacher preparation and educational leadership in higher education institutions across the state must support and develop pre-service and in-service teachers and leaders able to effectively incorporate standards and assessment consistent with this paradigm shift. Student leadership teams at Columbus State University were instructed in the use of a matrix alignment process as a learner-centered paradigm and effective assessment strategy to promote student achievement in P-12 education

    Leading from the engine room

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    © Springer International Publishing AG, part of Springer Nature 2018. This paper explores relationships and challenges facing teams creating simulation-based learning environments. Drawing on our experience of governance within Australian Indigenous cultures and specific work incidents as case studies, we explore tensions, triumphs and insights occurring during collaborative ventures intended to produce online learning activities. Our view is ‘from the engine room’ - at that point where technology and design expertise reframe creative ‘story boards’ into ‘interactive learning experiences’ requiring productive harnessing of diversity. Creation of scenario-based learning environments requires an understanding of specific content, along with the array of available learning pathways. Appreciating pitfalls likely to hinder the design process is vital. Scenarios use specific, and specialized artefacts and technologies to create interactive learning environments; computer-based technologies make the process even more complex, requiring highly specialized skills to contribute particular elements. More and more people are involved, and a greater number of specializations contribute to the final product. We draw on Human Computer Interaction practices to explore designer - developer interfaces and explore what may be involved in developing aware, conscious leadership of this emergent complexity. Words penned by Harrison (1967) aptly encapsulate our theme - “We were talking about the space between us all”

    Intersex in the clam Scrobicularia plana (Da Costa): Widespread occurrence in English Channel estuaries and surrounding areas

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    Estuarine clams Scrobicularia plana were sampled from 108 intertidal locations around the English Channel and adjacent areas. Although S. plana is believed to be a strict gonochorist, 58% of the populations sampled included intersexed individuals (described as male clams exhibiting ovotestis). Over the entire region, on average, 8.6% of male clams exhibited intersex, although proportions of affected males ranged from 0% to 53% depending on location. The severity of intersex was assessed using a simple classification scale, with the majority of individuals showing low levels of impact. Sex ratios were significantly skewed at some sites. There were no significant relationships between the incidence and severity of intersex; or of associations with size or parasitism of individual clams. Intersex in S. plana is a useful tool to assess endocrine disruptive effects in estuaries, although mechanisms of impact and causative agents remain uncertain

    National review of school music education: Augmenting the diminished

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    This study included a literature review, call for submissions, site visits, national survey and curriculum mapping to determine the current quality and status of music education in Australian schools. It provides an examination of the challenges facing schools in providing music education and highlights opportunities for strengthening music education in schools

    MEGA Vision: Integrating Reef Photogrammetry Data into Immersive Mixed Reality Experiences

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    Coral reefs and submerged cultural heritage sites are integral to supporting marine biodiversity, preserving human history, providing ecosystem services, and understanding drivers of ecosystem health and function. Despite the importance of these submerged underwater habitats, accessibility to these environments remains limited to specialized professionals. The MEGA Vision mixed reality application integrates photogrammetry-derived data products with augmented reality (AR) technologies to transcend this barrier, offering an immersive and educational platform for the broader public. Using high-resolution imagery from SCUBA expeditions, the app presents users with realistic and spatially accurate 3D reconstructions of coral reefs and submerged archaeological artifacts within an interactive interface developed through Unity and Vuforia. The applications’ instructional design includes multimedia elements for enhancing user comprehension of marine and historical sciences. This mixed reality tool exemplifies the convergence of scientific data visualization and public engagement, offering a unique educational tool that demystifies the complexities of marine ecosystems and maritime history, thereby fostering a deeper appreciation and stewardship of underwater environments. By enabling accessible, interactive, and immersive experiences, the application has the potential to revolutionize the way we interact with and contribute to marine sciences, aligning technology with conservation and research efforts to cultivate a more informed and environmentally conscious public

    Stress-resistance associated with multi-host transmission and enhanced biofilm formation at 42 °C among hyper-aerotolerant generalist Campylobacter jejuni

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    One of the emerging conundrums of Campylobacter food-borne illness is the bacterial ability to survive stressful environmental conditions. We evaluated the heterogeneity among 90 C. jejuni and 21 C. coli isolates from different sources in Egypt with respect to biofilm formation capabilities (under microaerobic and aerobic atmosphere) and resistance to a range of stressors encountered along the food chain (aerobic stress, refrigeration, freeze-thaw, heat, peracetic acid, and osmotic stress). High prevalence (63%) of hyper-aerotolerant (HAT) isolates was observed, exhibiting also a significantly high tolerance to heat, osmotic stress, refrigeration, and freeze-thaw stress, coupled with high biofilm formation ability which was clearly enhanced under aerobic conditions, suggesting a potential link between stress adaptation and biofilm formation. Most HAT multi-stress resistant and strong biofilm producing C. jejuni isolates belonged to host generalist clonal complexes (ST-21, ST-45, ST-48 and ST-206). These findings highlight the potential role of oxidative stress response systems in providing cross-protection (resistance to other multiple stress conditions) and enhancing biofilm formation in Campylobacter and suggest that selective pressures encountered in hostile environments have shaped the epidemiology of C. jejuni in Egypt by selecting the transmission of highly adapted isolates, thus promoting the colonization of multiple host species by important disease-causing lineages

    Molecular epidemiology and comparative genomics of <i>Campylobacter concisus</i> strains from saliva, faeces and gut mucosal biopsies in inflammatory bowel disease

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    Abstract Campylobacter concisus is an emerging pathogen associated with inflammatory bowel disease (IBD), yet little is known about the genetic diversity of C. concisus in relation to host niches and disease. We isolated 104 C. concisus isolates from saliva, mucosal biopsies and faecal samples from 41 individuals (26 IBD, 3 Gastroenteritis (GE), 12 Healthy controls (HC)). Whole genomes were sequenced and the dataset pan-genome examined, and genomic information was used for typing using multi-locus-sequence typing (MLST). C. concisus isolates clustered into two main groups/genomospecies (GS) with 71 distinct sequence types (STs) represented. Sampling site (p < 0.001), rather than disease phenotype (p = 1.00) was associated with particular GS. We identified 97 candidate genes associated with increase or decrease in prevalence during the anatomical descent from the oral cavity to mucosal biopsies to faeces. Genes related to cell wall/membrane biogenesis were more common in oral isolates, whereas genes involved in cell transport, metabolism and secretory pathways were more prevalent in enteric isolates. Furthermore, there was no correlation between individual genetic diversity and clinical phenotype. This study confirms the genetic heterogeneity of C. concisus and provides evidence that genomic variation is related to the source of isolation, but not clinical phenotype
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