The vulnerability and resiliency of childhood

Life is full of stressors, which have to be confronted efficiently to grow up. However, reaction to stressors is personalized, complex and coordinated. Vulnerable persons adjust poorly to stressors and express inappropriate responses, while resilient persons practice adaptive physiological and psychological responses. Promotion of resiliency is an intricated issue, which demands strategies at both macro and micro-level. Microlevel strategies are focused on the community, family and individual level, while macrolevel strategies formulate the principles. Nevertheless, prediction of vulnerability and resiliency is really a challenge, as different persons facing same stressors react differently. Some are growing as resilient and others as vulnerable. We aimed to discuss resiliency, vulnerability, importance in relation to health outcome, promotion of resiliency and controversies of vulnerability and resiliency

Walter Preston Boggess, Jr v. Lawrence Morris, Warden, Utah State Prison : Brief of Appellant

Appeal from the Judgment of the Third Judicial District Court, In and for Salt Lake County, State of Utah, the Honor-Able David K. Winder, Judge, Presidin

A Numerical Simulation of Turbulent Flow through a Curved Duct

This paper presents the comparison the results of an experimental work with a numerical work keeping the geometry of the test duct and inlet boundary conditions unaltered. The numerical simulation is validated with the experimental results based on the wall y+ approach for different turbulence models suited for this type of geometry. The experimental work is carried out at mass averaged mean velocity of 40m/s with the measurement of total pressure by a pre-calibrated multi-hole pressure probe and the results presented in the form of a pressure contours in 2-D. For validation of the numerical results Standard k-ε, k-ω and Reynolds Stress Model (RSM) are used to solve the closure problem. The turbulence models are investigated in the commercial CFD code of Fluent using y+ value as guidance in selecting the appropriate grid configuration and turbulence model. Based on the wall y+ values for different turbulence models, it is concluded in the present study that the mesh resolving the fully turbulent region is sufficiently accurate in terms of qualitative features and RSM turbulence model predicts the best results while comparing with the experimental results

Increased endothelial expression of Toll-like receptor 2 at sites of disturbed blood flow exacerbates early atherogenic events

Toll-like receptors (TLRs) are pattern recognition receptors of innate immunity. TLRs initiate inflammatory pathways that may exacerbate chronic inflammatory diseases like atherosclerosis. En face laser scanning confocal microscopy (LSCM) of isolated aortic segments revealed the distribution of intimal TLR2 expression and the atheroprotective outcomes resulting from a TLR2 deficiency. TLR2 expression was restricted to endothelial cells in regions of disturbed blood flow, such as the lesser curvature region, in atherosclerosis-prone, low-density lipoprotein receptor–deficient (LDLr−/−) mice. Diet-induced hyperlipidemia in LDLr−/− mice increased this regional endothelial TLR2 expression. Bone marrow (BM) reconstitution of LDLr−/− and LDLr−/−TLR2−/− mice created chimeric mice with green fluorescent protein (GFP) expression in BM-derived cells (BMGFP+). Lesser curvature BMGFP+ leukocyte accumulation, lipid accumulation, foam cell generation and endothelial cell injury were all increased by hyperlipidemia, whereas hyperlipidemic double mutant BMGFP+LDLr−/−TLR2−/− mice had reduced BMGFP+ leukocyte accumulation, lipid accumulation, foam cells, and endothelial cell injury. This is the first report of in vivo site-specific expression of endothelial cell TLR2. Expression of this receptor on endothelial cells contributed to early atherosclerotic processes in lesion-prone areas of the mouse aorta

Hospital based surveillance and genetic characterization of rotavirus strains in children (<5 years) with acute gastroenteritis in Kolkata, India, revealed resurgence of G9 and G2 genotypes during 2011–2013

AbstractIntroductionIndia accounts for an estimated 457,000–884,000 hospitalizations and 2 million outpatient visits for diarrhea. In spite of the huge burden of rotavirus (RV) disease, RV vaccines have not been introduced in national immunization programme of India. Therefore, continuous surveillance for prevalence and monitoring of the circulating genotypes is needed to assess the disease burden prior to introduction of vaccines in this region.MethodsDuring January 2011 through December 2013, 830 and 1000 stool samples were collected from hospitalized and out-patient department (OPD) patients, respectively, in two hospitals in Kolkata, Eastern India. After primary screening, the G-P typing was done by multiplex semi-nested PCR using type specific primers followed by sequencing. Phylogenetic analysis for the VP7 gene of 25 representative strains was done.ResultsAmong hospitalized and OPD patients, 53.4% and 47.5% cases were positive for rotaviruses, respectively. Unlike previous studies where G1 was predominant, in hospitalized cases G9 rotavirus strains were most prevalent (40%), followed by G2 (39.6%) whereas G1 and G12 occurred at 16.4% and 5.6% frequency. In OPD cases, the most prevalent strain was G2 (40.3%), followed by G1, G9 and G12 at 25.5%, 22.8%, 9.3%, respectively. Phylogenetically the G1, G2 and G9 strains from Kolkata did not cluster with corresponding genotypes of Rotarix, RotaTeq and Rotavac (116E) vaccine strains.ConclusionThe study highlights the high prevalence of RV in children with gastroenteritis in Kolkata. The circulating genotypes have changed over the time with predominance of G9 and G2 strains during 2011-2013. The current G2, G9 and G1 Kolkata strains shared low amino acid homologies with current vaccine strains. Although there is substantial evidence for cross protection of vaccines against a variety of strains, still the strain variation should be monitored post vaccine introduction to determine if it has any impact on vaccine effectiveness

Effect of incentives on the financial attractiveness of solar industrial process heating in India★

India has a huge industrial demand for process heating at temperatures that can be provided with commercially available solar collectors. Government of India with support from multi-lateral agencies has initiated an ambitious programme for promoting large scale adoption of Solar Industrial Process Heating (SIPH) in the industrial sector of the country. This paper presents the details of an attempt to study the effect of several existing and potential incentives on the financial attractiveness of SIPH systems in India. A case of solar process heating in dairy industry has been presented to demonstrate the relative efficacy of different incentives on the economics of SIPH systems in terms of their impact on levelized cost of useful thermal energy delivered. Finally, policy implications of the results obtained have been discussed

Effect of incentives on the financial attractiveness of solar industrial process heating in India

India has a huge industrial demand for process heating at temperatures that can be provided with commercially available solar collectors. Government of India with support from multi-lateral agencies has initiated an ambitious programme for promoting large scale adoption of Solar Industrial Process Heating (SIPH) in the industrial sector of the country. This paper presents the details of an attempt to study the effect of several existing and potential incentives on the financial attractiveness of SIPH systems in India. A case of solar process heating in dairy industry has been presented to demonstrate the relative efficacy of different incentives on the economics of SIPH systems in terms of their impact on levelized cost of useful thermal energy delivered. Finally, policy implications of the results obtained have been discussed

Dissipative collisions in 16^{16}O + 27^{27}Al at Elab_{lab}=116 MeV

The inclusive energy distributions of fragments (3$\leq$Z$\leq$7) emitted in the reaction $^{16}$O + $^{27}$Al at $E_{lab} =$116 MeV have been measured in the angular range $\theta_{lab}$= 15$^\circ$ - 115$^\circ$. A non-linear optimisation procedure using multiple Gaussian distribution functions has been proposed to extract the fusion-fission and deep inelastic components of the fragment emission from the experimental data. The angular distributions of the fragments, thus obtained, from the deep inelastic component are found to fall off faster than those from the fusion-fission component, indicating shorter life times of the emitting di-nuclear systems. The life times of the intermediate di-nuclear configurations have been estimated using a diffractive Regge-pole model. The life times thus extracted ($\sim 1 - 5\times 10^{-22}$ Sec.) are found to decrease with the increase in the fragment charge. Optimum Q-values are also found to increase with increasing charge transfer i.e. with the decrease in fragment charge.Comment: 9 pages, 4 figures, 1 tabl