The role of the apelin/APJ system in water homeostasis regulation

Water balance in the body is achieved by balancing renal and non-renal water losses with corresponding water intake. It is under the control of both the central nervous system, which integrates many parameters of water and electrolyte balance in the body, including inducing important adaptive behavioral responses, and three hormonal systems: vasopressinergic, renin-angiotensin-aldosterone and apelinergic. A lot of research is devoted to the regulation of water-electrolyte metabolism. However, this process is still quite difficult to understand, especially since more and more of its regulators are being discovered over time. One of them is the hormone apelin, an endogenous ligand for the APJ receptor. As is known, the receptor is highly expressed in many organs, such as the brain, heart, liver and kidneys, lungs, and has multidirectional effects.This literature review discusses the main characteristics and features of the regulation of these systems in relation to water-electrolyte metabolism, as well as issues of intersystem interaction and modulation of the effects of apelin

Macrophage activation syndrome (MAS) in juvenile systemic lupus erythematosus (JSLE): an underrecognized complication?

PubMe

ORGANIZING-ECONOMIC PARTICULARITY TO SOCIAL ADAPTING THE PEOPLE WITH PHYSICAL DEFLECTIONS

The social stratification deepens in modern Russian society that finds living and in system of the formation. The Variety of the forms and methods of the education is accompanied from and sequesterring approach to participant of the pedagogical process. There are the processes to localizations of the formation, giving to him of the forms, that is reached orientation on the individual (above the average) to particularities of the development, on "purse of the parents", on religious or attribute. Omni directional, public need, integer and function, executed once-personal social institute, obstruct institute general and special formation, development of the programs to social rehabilitation and integrations, mode supports. The Influence process data particularly sharply feel on itself people with limited carry of health (OVZ), their families and that social structures, which is called cotton wool to him social, pedagogical help. The Category of the persons with OVZ is presented by people of the miscellaneous of the age, having different on degree of the difficulties and nature decline-thread in development

Treatment of ACTH-ectopic syndrome with long-acting octreotide: effective control of disease activity

ACTH — ectopic syndrome (ACTH-ES) is a severe multisystem disease caused by paraneoplastic secretion of ACTH itself and/or much less often corticoliberin (CL) by tumor tissue. The frequency of ACTH-ES is 12–20% of cases of endogenous hypercortisolism, i.e. about 1–2 cases per million population, and covers a range of tumors, from benign neoplasms to malignant tumors with widespread metastases, while the most common causes of ACTH-ES are tumors of the lung, pancreas and thymus, and more rare localizations are neuroendocrine tumors (NET) of the intestine, medullary thyroid cancer, pheochromocytoma and mesothelioma. The optimal treatment for ACTH-ES is to remove the ACTH-secreting tumor. For patients with an unidentified source of ectopic hormone secretion, the choice is narrowed to bilateral adrenalectomy followed by hormone replacement therapy with glucocorticoids and mineralocorticoids. Medication options are generally a low-effective/palliative treatment option. In this article, we present a clinical case of the successful use of long-acting octreotide in a 36-year-old woman with severe ACTH-ES for long-term control of paraneoplastic ACTH secretion, against which a clinical and biochemical improvement comparable to complete remission of the disease was achieved

SOLUBILITY AND DESTRUCTION OF OIL IN SEA WATER

The solubility and the destruction of crude oil in seawater in conditions of the Caspian sea have been studied