8 research outputs found
Systematic study of the pp -> pp omega reaction
A systematic study of the production of omega-mesons in
proton-proton-collisions was carried out in a kinematically complete experiment
at three excess energies(epsilon= 92, 128, 173MeV). Both protons were detected
using the large-acceptance COSY-TOF spectrometer at an external beam line at
the Cooler Synchrotron COSY at Forschungszentrum J\"ulich. The total cross
section, angular distributions of both omega-mesons and protons were measured
and presented in various reference frames such as the overall CMS, helicity and
Jackson frame. In addition, the orientation of the omega-spin and invariant
mass spectra were determined. We observe omega-production to take place
dominantly in Ss and Sp final states at epsilon = 92, 128 MeV and,
additionally, in Sd at epsilon= 173 MeV. No obvious indication of resonant
omega-production via N^*-resonances was found, as proton angular distributions
are almost isotropic and invariant mass spectra are compatible with phase space
distributions. A dominant role of ^3P_1 and ^1S_0 initial partial waves for
omega-production was concluded from the orientation of the decay plane of the
omega-meson. Although the Jackson angle distributions in the omega-p-Jackson
frame are anisotropic we argue that this is not an indication of a resonance
but rather a kinematical effect reflecting the anisotropy of the omega angular
distribution. The helicity angle distribution in the omega-p-helicity frame
shows an anisotropy which probably reflects effects of the omega angular
momenta in the final state; this observable may be, in addition to the
orientation of the omega decay plane, the most sensitive one to judge the
validity of theoretical descriptions of the production process.Comment: 17 pages, 16 figures, accepted for publication in EPJ
New fluorescent probe for protein and nucleoprotein conformation. Binding of 7-(p-methoxybenzylamino)-4-nitrobenzoxadiazole to bovine trypsinogen and bacterial ribosomes
Interaction of elongation factor Tu with the aminoacyl transfer ribonucleic acid dimer Phe-tRNA-Glu-tRNA
Transient Conformational States of Aminoacyl-tRNA during Ribosome Binding Catalyzed by Elongation Factor Tu
Intravenous NPA for the treatment of infarcting myocardium early: InTIME-II, a double-blind comparison on of single-bolus lanoteplase vs accelerated alteplase for the treatment of patients with acute myocardial infarction
Aims to compare the efficacy and safety of lanoteplase, a single-bolus thrombolytic drug derived from alteplase tissue plasminogen activator, with the established accelerated alteplase regimen in patients presenting within 6 h of onset of ST elevation acute myocardial infarction. Methods and Results 15 078 patients were recruited from 855 hospitals worldwide and randomized in a 2:1 ratio to receive either lanoteplase 120 KU. kg-1 as a single intravenous bolus, or up to 100 mg accelerated alteplase given over 90 min. The primary end-point was all-cause mortality at 30 days and the hypothesis was that the two treatments would be equivalent. By 30 days, 6.61% of alteplase-treated patients and 6.75% lanoteplase-treated patients had died (relative risk 1.02). Total stroke occurred in 1.53% alteplase- and 1.87% lanoteplase-treated patients (ns); haemorrhagic stroke rates were 0.64% alteplase and 1.12% lanoteplase (P=0.004). The net clinical deficit of 30-day death or non-fatal disabling stroke was 7.0% and 7.2%, respectively. By 6 months, 8.8% of alteplase-treated patients and 8.7% of lanoteplase-treated patients had died. Conclusion Single-bolus weight-adjusted lanoteplase is an effective thrombolytic agent, equivalent to alteplase in terms of its impact on survival and with a comparable risk-benefit profile. The single-bolus regimen should shorten symptoms to treatment times and be especially convenient for emergency department or out-of-hospital administration. (C) 2000 The European Society of Cardiology