Large scale structure in the HI Parkes All-Sky Survey: Filling the Voids with HI galaxies?

We estimate the two-point correlation function in redshift space of the recently compiled HIPASS neutral hydrogen (HI) sources catalogue, which if modeled as a power law, $\xi(r)=(r_{0}/r)^{\gamma}$, the best-fitting parameters for the HI selected galaxies are found to be $r_{0}=3.3 \pm 0.3 h^{-1}$ Mpc with $\gamma=1.38 \pm 0.24$. Fixing the slope to its universal value $\gamma=1.8$, we obtain $r_{0}= 3.2\pm 0.2 h^{-1}$ Mpc. Comparing the measured two point correlation function with the predictions of the concordance cosmological model, we find that at the present epoch the HI selected galaxies are anti-biased with respect to the underlying matter fluctuation field with their bias value being $b_{0}\simeq 0.68$. Furthermore, dividing the HI galaxies into two richness subsamples we find that the low mass HI galaxies have a very low present bias factor ($b_{0}\simeq 0.48$), while the high mass HI galaxies trace the underlying matter distribution as the optical galaxies ($b_{0}\simeq 1$). Using our derived present-day HI galaxy bias we estimate their redshift space distortion parameter, and correct accordingly the correlation function for peculiar motions. The resulting real-space correlation length is $r^{\rm re}_{0}=1.8 \pm 0.2 h^{-1}$Mpc and $r^{\rm re}_{0}=3.9 \pm 0.6 h^{-1}$Mpc for the low and high mass HI galaxies, respectively. The low-mass HI galaxies appear to have the lowest correlation length among all extragalactic populations studied to-date. Also, we have correlated the IRAS-PSCz reconstructed density field, smoothed over scales of 5$h^{-1}$ Mpc, with the positions of the HI galaxies, to find that indeed the HI galaxies are typically found in negative overdensity regions (\delta\rho/\rho_{\rm PSCz} \mincir 0).Comment: 9 pages, 8 figures, MNRAS in pres

Tackling obstacles for gene therapy targeting neurons: disrupting perineural nets with hyaluronidase improves transduction.

Gene therapy has been proposed for many diseases in the nervous system. In most cases for successful treatment, therapeutic vectors must be able to transduce mature neurons. However, both in vivo, and in vitro, where preliminary characterisation of viral particles takes place, transduction of neurons is typically inefficient. One possible explanation is that the extracellular matrix (ECM), forming dense perineural nets (PNNs) around neurons, physically blocks access to the cell surface. We asked whether co-administration of lentiviral vectors with an enzyme that disrupts the ECM could improve transduction efficiency. Using hyaluronidase, an enzyme which degrades hyaluronic acid, a high molecular weight molecule of the ECM with mainly a scaffolding function, we show that in vitro in mixed primary cortical cultures, and also in vivo in rat cortex, hyaluronidase co-administration increased the percentage of transduced mature, NeuN-positive neurons. Moreover, hyaluronidase was effective at doses that showed no toxicity in vitro based on propidium iodide staining of treated cultures. Our data suggest that limited efficacy of neuronal transduction is partly due to PNNs surrounding neurons, and further that co-applying hyaluronidase may benefit applications where efficient transduction of neurons in vitro or in vivo is required

Problem of Bundled Two-Wire Cable of Tested Equipment in Emission Measurement

Many factors that influence radiated emission measurement exist. Except of factors relative to measuring chain \"test site - antenna - receiver\" there are some factors caused by operating personnel like inappropriate configuration of tested equipment, etc. Tested equipments contain generally attached cables of different length; the longer ones shall be shortened by folding into a bundle. The aim of this paper is to analyze the behavior of such cables and its influence on results of radiated emission measurement

Evaluation of Measurement Performance in Averaging Quantization System with Noise

Statistical description of quantization process is common in the theory of quantization. For the case of nonsubtractive dither theoretical analyses of the dithered quantizer have been confronted with experimental results. As a quantization system one-chip microcomputer with the analog-to-digital converter on a chip has been used. Generally valid criteria for dithered system performance have been practically applied for Gaussian dither. Interaction of natural noise present in the signal with an added Gaussian noise of several different disperses and influence of differential nonlinearity of the converter has been observed

A massive, distant proto-cluster at z=2.47 caught in a phase of rapid formation?

Numerical simulations of cosmological structure formation show that the Universe's most massive clusters, and the galaxies living in those clusters, assemble rapidly at early times (2.5 < z < 4). While more than twenty proto-clusters have been observed at z > 2 based on associations of 5-40 galaxies around rare sources, the observational evidence for rapid cluster formation is weak. Here we report observations of an asymmetric, filamentary structure at z = 2.47 containing seven starbursting, submillimeter-luminous galaxies and five additional AGN within a comoving volume of 15000 Mpc$^{3}$. As the expected lifetime of both the luminous AGN and starburst phase of a galaxy is ~100 Myr, we conclude that these sources were likely triggered in rapid succession by environmental factors, or, alternatively, the duration of these cosmologically rare phenomena is much longer than prior direct measurements suggest. The stellar mass already built up in the structure is $\sim10^{12}M_{\odot}$ and we estimate that the cluster mass will exceed that of the Coma supercluster at $z \sim 0$. The filamentary structure is in line with hierarchical growth simulations which predict that the peak of cluster activity occurs rapidly at z > 2.Comment: 7 pages, 3 figures, 2 tables, accepted in ApJL (small revisions from previous version

Cosmic Microwave Background Anisotropy Measurement From Python V

We analyze observations of the microwave sky made with the Python experiment in its fifth year of operation at the Amundsen-Scott South Pole Station in Antarctica. After modeling the noise and constructing a map, we extract the cosmic signal from the data. We simultaneously estimate the angular power spectrum in eight bands ranging from large (l ~ 40) to small (l ~ 260) angular scales, with power detected in the first six bands. There is a significant rise in the power spectrum from large to smaller (l ~ 200) scales, consistent with that expected from acoustic oscillations in the early Universe. We compare this Python V map to a map made from data taken in the third year of Python. Python III observations were made at a frequency of 90 GHz and covered a subset of the region of the sky covered by Python V observations, which were made at 40 GHz. Good agreement is obtained both visually (with a filtered version of the map) and via a likelihood ratio test.Comment: 28 pages, ApJ accepted, to appear v584 n2 ApJ Feb 20, 200

Anisotropy in the Cosmic Microwave Background at Degree Angular Scales: Python V Results

Observations of the microwave sky using the Python telescope in its fifth season of operation at the Amundsen-Scott South Pole Station in Antarctica are presented. The system consists of a 0.75 m off-axis telescope instrumented with a HEMT amplifier-based radiometer having continuum sensitivity from 37-45 GHz in two frequency bands. With a 0.91 deg x 1.02 deg beam the instrument fully sampled 598 deg^2 of sky, including fields measured during the previous four seasons of Python observations. Interpreting the observed fluctuations as anisotropy in the cosmic microwave background, we place constraints on the angular power spectrum of fluctuations in eight multipole bands up to l ~ 260. The observed spectrum is consistent with both the COBE experiment and previous Python results. There is no significant contamination from known foregrounds. The results show a discernible rise in the angular power spectrum from large (l ~ 40) to small (l ~ 200) angular scales. The shape of the observed power spectrum is not a simple linear rise but has a sharply increasing slope starting at l ~ 150.Comment: 5 page