23 research outputs found
Historical Retrospective Review of Idea of University: Complementarily of Reason and Spirituality
Background: In the paper the Idea of the University and its transformations throughout the history are analysed. The content of the Idea of the University was based on understanding of spirituality when the man is upcoming to enlightening. Religion, philosophy, and education get together, when spirituality is defined as the categories and personal characteristics of a human. According to philosophy, spirituality is a non-physical way of a human being, which was granted to him as the ability of self-education. Religion understands spirituality as invariant of enlightening. The scientific-methodical apparatus of education was created to realize the potential ways for raising a person to enlightening in secular or religious schools. The spiritual aura was constantly presented at the University. Methods: A general philosophical approach and comparative historical method were used in the research. Results: Understanding the role of spirituality in the University education was absolutely manifested. The University was based on the idea of going up from individual towards the Universal Truth and Absolute Spirit. Knowledge and Truth are ideological categories of the University. Truth contained the spirituality and rational knowledge in the unity. Conclusions: The University has not lost its Idea throughout the history. The basic conclusion of the paper is that its Idea as well as its essence is the change of its criteria in response to the new historical reality
Full-wave invisibility of active devices at all frequencies
There has recently been considerable interest in the possibility, both
theoretical and practical, of invisibility (or "cloaking") from observation by
electromagnetic (EM) waves. Here, we prove invisibility, with respect to
solutions of the Helmholtz and Maxwell's equations, for several constructions
of cloaking devices. Previous results have either been on the level of ray
tracing [Le,PSS] or at zero frequency [GLU2,GLU3], but recent numerical [CPSSP]
and experimental [SMJCPSS] work has provided evidence for invisibility at
frequency . We give two basic constructions for cloaking a region
contained in a domain from measurements of Cauchy data of waves at \p
\Omega; we pay particular attention to cloaking not just a passive object, but
an active device within , interpreted as a collection of sources and sinks
or an internal current.Comment: Final revision; to appear in Commun. in Math. Physic
ΠΡΠ΅Π½ΠΊΠ° ΠΏΠ΅ΡΡΠΏΠ΅ΠΊΡΠΈΠ²Ρ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΡ ΠΌΠΎΠ΄Π΅Π»ΠΈ Π³Π΅ΡΡΠ°ΡΠΈΠΎΠ½Π½ΠΎΠ³ΠΎ ΡΠ°Ρ Π°ΡΠ½ΠΎΠ³ΠΎ Π΄ΠΈΠ°Π±Π΅ΡΠ° Π΄Π»Ρ ΠΏΠΎΠΈΡΠΊΠ° ΡΡΠ΅Π΄ΡΡΠ² ΡΠ°ΡΠΌΠ°ΠΊΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΊΠΎΡΡΠ΅ΠΊΡΠΈΠΈ Π½Π°ΡΡΡΠ΅Π½ΠΈΠΉ Ρ ΠΏΠΎΡΠΎΠΌΡΡΠ²Π° ΠΊΡΡΡ
Imbalance of glucose homeostasis in the mother-placenta-fetus system in case of gestational diabetes mellitus (GDM) leads to pre- and postnatal abnormalities in offspring. Lack of universally recognized GDM-model complicates the search for pathogenetic means to prevent and correct abnormalities in offspring. A model using food load (high-calorie diet) in combination with low doses of diabetogen streptozotocin (HCD-STZ model) seems to be one of the closest in causes, mechanisms of development and clinical findings. Hence, the aim was to work out and assess the suitability of HCD-STZ model of GDM in order to register abnormalities in the offspring and determine the possibility of their pharmacological correction. Rats and its fetuses were the objects of the study. Modeling of GDM involved keeping rats on a high-calorie diet (NCD) for at least 10 weeks followed by a single injection of low-dose STZ on the first day of gestation. The hyperglycemia characteristic of GDM is recorded in less than 40 % of animals in HCD group combined with streptozotocin at a dose of 25 mg/kg. This fact does not allow a reliable assessment of abnormalities of antenatal and postnatal development of offspring. Thus, the model used is not promising for finding means of pharmacological correction of the effect of GDM on offspring.ΠΠ°ΡΡΡΠ΅Π½ΠΈΠ΅ Π³ΠΎΠΌΠ΅ΠΎΡΡΠ°Π·Π° Π³Π»ΡΠΊΠΎΠ·Ρ Π² ΡΠΈΡΡΠ΅ΠΌΠ΅ Β«ΠΌΠ°ΡΡβΠΏΠ»Π°ΡΠ΅Π½ΡΠ°βΠΏΠ»ΠΎΠ΄Β» ΠΏΡΠΈ Π³Π΅ΡΡΠ°ΡΠΈΠΎΠ½Π½ΠΎΠΌ ΡΠ°Ρ
Π°ΡΠ½ΠΎΠΌ Π΄ΠΈΠ°Π±Π΅ΡΠ΅ (ΠΠ‘Π) Π²Π΅Π΄ΡΡ ΠΊ ΠΏΡΠ΅- ΠΈ ΠΏΠΎΡΡΠ½Π°ΡΠ°Π»ΡΠ½ΡΠΌ ΠΎΡΠΊΠ»ΠΎΠ½Π΅Π½ΠΈΡΠΌ Ρ ΠΏΠΎΡΠΎΠΌΡΡΠ²Π°. ΠΡΡΡΡΡΡΠ²ΠΈΠ΅ ΠΎΠ±ΡΠ΅ΠΏΡΠΈΠ·Π½Π°Π½Π½ΠΎΠΉ ΠΌΠΎΠ΄Π΅Π»ΠΈ ΠΠ‘Π ΠΎΡΠ»ΠΎΠΆΠ½ΡΠ΅Ρ ΠΏΠΎΠΈΡΠΊ ΠΏΠ°ΡΠΎΠ³Π΅Π½Π΅ΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΡΠ΅Π΄ΡΡΠ² ΠΏΡΠ΅Π΄ΡΠΏΡΠ΅ΠΆΠ΄Π΅Π½ΠΈΡ ΠΈ ΠΊΠΎΡΡΠ΅ΠΊΡΠΈΠΈ ΠΎΡΠΊΠ»ΠΎΠ½Π΅Π½ΠΈΠΉ Ρ ΠΏΠΎΡΠΎΠΌΡΡΠ²Π°. ΠΠ΄Π½ΠΎΠΉ ΠΈΠ· Π½Π°ΠΈΠ±ΠΎΠ»Π΅Π΅ Π±Π»ΠΈΠ·ΠΊΠΈΡ
ΠΏΠΎ ΠΏΡΠΈΡΠΈΠ½Π°ΠΌ Π²ΠΎΠ·Π½ΠΈΠΊΠ½ΠΎΠ²Π΅Π½ΠΈΡ, ΠΌΠ΅Ρ
Π°Π½ΠΈΠ·ΠΌΠ°ΠΌ ΡΠ°Π·Π²ΠΈΡΠΈΡ ΠΈ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΊΠ°ΡΡΠΈΠ½Π΅ ΠΏΡΠ΅Π΄ΡΡΠ°Π²Π»ΡΠ΅ΡΡΡ ΠΌΠΎΠ΄Π΅Π»Ρ Ρ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΠ΅ΠΌ ΠΏΠΈΡΠ΅Π²ΠΎΠΉ Π½Π°Π³ΡΡΠ·ΠΊΠΈ (Π²ΡΡΠΎΠΊΠΎΠΊΠ°Π»ΠΎΡΠΈΠΉΠ½ΠΎΠΉ Π΄ΠΈΠ΅ΡΡ) Π² ΠΊΠΎΠΌΠ±ΠΈΠ½Π°ΡΠΈΠΈ Ρ Π½ΠΈΠ·ΠΊΠΈΠΌΠΈ Π΄ΠΎΠ·Π°ΠΌΠΈ Π΄ΠΈΠ°Π±Π΅ΡΠΎΠ³Π΅Π½Π° ΡΡΡΠ΅ΠΏΡΠΎΠ·ΠΎΡΠΎΡΠΈΠ½Π° (ΠΠΠ-Π‘Π’Π-ΠΌΠΎΠ΄Π΅Π»Ρ). ΠΡΡΡΠ΄Π° Π²ΠΎΠ·Π½ΠΈΠΊΠ»Π° Π·Π°Π΄Π°ΡΠ° ΠΏΠΎ ΠΎΡΡΠ°Π±ΠΎΡΠΊΠ΅ ΠΈ ΠΎΡΠ΅Π½ΠΊΠ΅ ΠΏΡΠΈΠ³ΠΎΠ΄Π½ΠΎΡΡΠΈ ΠΠΠ-Π‘Π’Π-ΠΌΠΎΠ΄Π΅Π»ΠΈ ΠΠ‘Π Ρ ΡΠ΅Π»ΡΡ ΡΠ΅Π³ΠΈΡΡΡΠ°ΡΠΈΠΈ ΠΎΡΠΊΠ»ΠΎΠ½Π΅Π½ΠΈΠΉ Ρ ΠΏΠΎΡΠΎΠΌΡΡΠ²Π° ΠΈ ΠΏΠΎΡΠ»Π΅Π΄ΡΡΡΠΈΠΌ ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΠ΅ΠΌ Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎΡΡΠΈ ΠΈΡ
ΡΠ°ΡΠΌΠ°ΠΊΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΊΠΎΡΡΠ΅ΠΊΡΠΈΠΈ. ΠΠ±ΡΠ΅ΠΊΡΠΎΠΌ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ ΡΠ»ΡΠΆΠΈΠ»ΠΈ ΠΊΡΡΡΡ ΠΈ ΠΏΠ»ΠΎΠ΄Ρ ΠΊΡΡΡ. ΠΠΎΠ΄Π΅Π»ΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ ΠΠ‘Π ΠΏΡΠ΅Π΄ΡΡΠΌΠ°ΡΡΠΈΠ²Π°Π»ΠΎ ΡΠΎΠ΄Π΅ΡΠΆΠ°Π½ΠΈΠ΅ ΠΊΡΡΡ Π½Π° Π²ΡΡΠΎΠΊΠΎΠΊΠ°Π»ΠΎΡΠΈΠΉΠ½ΠΎΠΉ Π΄ΠΈΠ΅ΡΠ΅ (ΠΠΠ) Π² ΡΠ΅ΡΠ΅Π½ΠΈΠ΅ Π½Π΅ ΠΌΠ΅Π½Π΅Π΅ 10 Π½Π΅Π΄Π΅Π»Ρ Ρ ΠΏΠΎΡΠ»Π΅Π΄ΡΡΡΠΈΠΌ ΠΎΠ΄Π½ΠΎΠΊΡΠ°ΡΠ½ΡΠΌ Π²Π²Π΅Π΄Π΅Π½ΠΈΠ΅ΠΌ Π½ΠΈΠ·ΠΊΠΈΡ
Π΄ΠΎΠ· ΡΡΡΠ΅ΠΏΡΠΎΠ·ΠΎΡΠΎΡΠΈΠ½Π° (Π‘Π’Π) Π² ΠΏΠ΅ΡΠ²ΡΠΉ Π΄Π΅Π½Ρ Π±Π΅ΡΠ΅ΠΌΠ΅Π½Π½ΠΎΡΡΠΈ. ΠΡΠΈ ΠΠΠ Π² ΡΠΎΡΠ΅ΡΠ°Π½ΠΈΠΈ Ρ Π‘Π’Π Π² Π΄ΠΎΠ·Π΅ 25 ΠΌΠ³/ΠΊΠ³ Π³ΠΈΠΏΠ΅ΡΠ³Π»ΠΈΠΊΠ΅ΠΌΠΈΡ, Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠ½Π°Ρ Π΄Π»Ρ ΠΠ‘Π, ΡΠ΅Π³ΠΈΡΡΡΠΈΡΡΠ΅ΡΡΡ ΠΌΠ΅Π½Π΅Π΅ ΡΠ΅ΠΌ Ρ 40 % ΠΆΠΈΠ²ΠΎΡΠ½ΡΡ
, ΡΡΠΎ Π² Π΄Π°Π»ΡΠ½Π΅ΠΉΡΠ΅ΠΌ Π½Π΅ ΠΏΠΎΠ·Π²ΠΎΠ»ΡΠ΅Ρ Π΄ΠΎΡΡΠΎΠ²Π΅ΡΠ½ΠΎ ΠΎΡΠ΅Π½ΠΈΡΡ Π½Π°ΡΡΡΠ΅Π½ΠΈΡ Π°Π½ΡΠ΅Π½Π°ΡΠ°Π»ΡΠ½ΠΎΠ³ΠΎ ΠΈ ΠΏΠΎΡΡΠ½Π°ΡΠ°Π»ΡΠ½ΠΎΠ³ΠΎ ΡΠ°Π·Π²ΠΈΡΠΈΡ Ρ ΠΏΠΎΡΠΎΠΌΡΡΠ²Π°. Π’Π°ΠΊΠΈΠΌ ΠΎΠ±ΡΠ°Π·ΠΎΠΌ, ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½Π½Π°Ρ ΠΌΠΎΠ΄Π΅Π»Ρ Π½Π΅ ΠΏΠ΅ΡΡΠΏΠ΅ΠΊΡΠΈΠ²Π½Π° Π΄Π»Ρ ΠΏΠΎΠΈΡΠΊΠ° ΡΡΠ΅Π΄ΡΡΠ² ΡΠ°ΡΠΌΠ°ΠΊΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΊΠΎΡΡΠ΅ΠΊΡΠΈΠΈ Π²Π»ΠΈΡΠ½ΠΈΡ ΠΠ‘Π Π½Π° ΠΏΠΎΡΠΎΠΌΡΡΠ²ΠΎ
ΠΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ ΡΡΠ±Ρ ΡΠΎΠ½ΠΈΡΠ΅ΡΠΊΠΎΠΉ ΡΠΎΠΊΡΠΈΡΠ½ΠΎΡΡΠΈ ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΠ° ΠΠ°Π½ΡΠΈΠ½ΠΎΡΠΌ ΠΡΠ±ΠΈ
Presents results of a study of subchronic toxicity of homeopathic drug Dantinorm Baby in finished dosage form. The drug in the form of a ready solution was administered daily orally for one month to outbred rats Infanta and chinchilla rabbits at a dose of 0.3 ml/kg, corresponding to the therapeutic, and 3 ml/kg, exceeding the therapeutic dose 10 times. Clinical, laboratory and histopathological studies performed in accordance with the General Protocol, showed no toxic effects of homeopathic preparation of Dantinorm Baby. The totality of the obtained data of the subchronic experiment indicates that there are no obstacles to the clinical study of the drug Dantinorm Baby in the range of therapeutic dosages.ΠΡΠ΅Π΄ΡΡΠ°Π²Π»Π΅Π½Ρ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΡ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ ΡΡΠ±Ρ
ΡΠΎΠ½ΠΈΡΠ΅ΡΠΊΠΎΠΉ ΡΠΎΠΊΡΠΈΡΠ½ΠΎΡΡΠΈ Π³ΠΎΠΌΠ΅ΠΎΠΏΠ°ΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΠ° ΠΠ°Π½ΡΠΈΠ½ΠΎΡΠΌ ΠΡΠ±ΠΈ Π² Π³ΠΎΡΠΎΠ²ΠΎΠΉ Π»Π΅ΠΊΠ°ΡΡΡΠ²Π΅Π½Π½ΠΎΠΉ ΡΠΎΡΠΌΠ΅. ΠΡΠ΅ΠΏΠ°ΡΠ°Ρ Π² Π²ΠΈΠ΄Π΅ Π³ΠΎΡΠΎΠ²ΠΎΠ³ΠΎ ΡΠ°ΡΡΠ²ΠΎΡΠ° Π²Π²ΠΎΠ΄ΠΈΠ»ΠΈ Π΅ΠΆΠ΅Π΄Π½Π΅Π²Π½ΠΎ ΠΏΠ΅ΡΠΎΡΠ°Π»ΡΠ½ΠΎ Π² ΡΠ΅ΡΠ΅Π½ΠΈΠ΅ ΠΎΠ΄Π½ΠΎΠ³ΠΎ ΠΌΠ΅ΡΡΡΠ° Π°ΡΡΠ±ΡΠ΅Π΄Π½ΡΠΌ ΠΊΡΡΡΠ°ΠΌ ΠΈΠ½ΡΠ°Π½ΡΠ°ΠΌ ΠΈ ΠΊΡΠΎΠ»ΠΈΠΊΠ°ΠΌ ΠΏΠΎΡΠΎΠ΄Ρ ΡΠΈΠ½ΡΠΈΠ»Π»Π° Π² Π΄ΠΎΠ·Π΅ 0,3 ΠΌΠ»/ΠΊΠ³, ΡΠΎΠΎΡΠ²Π΅ΡΡΡΠ²ΡΡΡΠ΅ΠΉ ΡΠ΅ΡΠ°ΠΏΠ΅Π²ΡΠΈΡΠ΅ΡΠΊΠΎΠΉ, ΠΈ 3 ΠΌΠ»/ΠΊΠ³, ΠΏΡΠ΅Π²ΡΡΠ°ΡΡΠ΅ΠΉ ΡΠ΅ΡΠ°ΠΏΠ΅Π²ΡΠΈΡΠ΅ΡΠΊΡΡ Π΄ΠΎΠ·Ρ Π² 10 ΡΠ°Π·. ΠΠ»ΠΈΠ½ΠΈΠΊΠΎ-Π»Π°Π±ΠΎΡΠ°ΡΠΎΡΠ½ΡΠ΅ ΠΈ ΠΏΠ°ΡΠΎΠ³ΠΈΡΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ, Π²ΡΠΏΠΎΠ»Π½Π΅Π½Π½ΡΠ΅ Π² ΡΠΎΠΎΡΠ²Π΅ΡΡΡΠ²ΠΈΠΈ Ρ ΠΎΠ±ΡΠ΅ΠΏΡΠΈΠ½ΡΡΡΠΌ ΠΏΡΠΎΡΠΎΠΊΠΎΠ»ΠΎΠΌ, ΠΏΡΠΎΠ΄Π΅ΠΌΠΎΠ½ΡΡΡΠΈΡΠΎΠ²Π°Π»ΠΈ ΠΎΡΡΡΡΡΡΠ²ΠΈΠ΅ ΡΠΎΠΊΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΡΡΠ΅ΠΊΡΠΎΠ² Π³ΠΎΠΌΠ΅ΠΎΠΏΠ°ΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΠ° ΠΠ°Π½ΡΠΈΠ½ΠΎΡΠΌ ΠΡΠ±ΠΈ. Π‘ΠΎΠ²ΠΎΠΊΡΠΏΠ½ΠΎΡΡΡ ΠΏΠΎΠ»ΡΡΠ΅Π½Π½ΡΡ
Π΄Π°Π½Π½ΡΡ
ΡΡΠ±Ρ
ΡΠΎΠ½ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΡΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ° ΡΠ²ΠΈΠ΄Π΅ΡΠ΅Π»ΡΡΡΠ²ΡΠ΅Ρ ΠΎΠ± ΠΎΡΡΡΡΡΡΠ²ΠΈΠΈ ΠΏΡΠ΅ΠΏΡΡΡΡΠ²ΠΈΠΉ ΠΊ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΎΠΌΡ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΠ° ΠΠ°Π½ΡΠΈΠ½ΠΎΡΠΌ ΠΡΠ±ΠΈ Π² Π΄ΠΈΠ°ΠΏΠ°Π·ΠΎΠ½Π΅ ΡΠ΅ΡΠ°ΠΏΠ΅Π²ΡΠΈΡΠ΅ΡΠΊΠΈΡ
Π΄ΠΎΠ·ΠΈΡΠΎΠ²ΠΎΠΊ
ΠΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ ΠΎΡΡΡΠΎΠΉ ΡΠΎΠΊΡΠΈΡΠ½ΠΎΡΡΠΈ ΡΠ°Π±Π»Π΅ΡΠΎΠΊ ΠΠΎΠΌΠ΅ΠΎΠ²ΠΎΠΊΡ, ΠΏΠΎΠΊΡΡΡΡΡ ΠΎΠ±ΠΎΠ»ΠΎΡΠΊΠΎΠΉ, Π³ΠΎΠΌΠ΅ΠΎΠΏΠ°ΡΠΈΡΠ΅ΡΠΊΠΈΡ
Relevance. Assessment of acute toxicity is a necessary stage of preclinical research of a tablets Homeovox homeopathic. The aim of present research is study of acute toxicity Homeovox.Methods. Homeovox was administered once orally and intraperitoneally to mice and rats in the maximum possible volumes for each of the administration methods and for each animal species, at the highest possible concentrations. Equivalent volume of 1 % starch solution was administered to animals of the control groups. Euthanasia and pathoanatomical dissection were performed 14 days after drug administration. Periods of animals intoxication with a detailed description of the observed clinical picture were registered.Results. The median fatal doses were not identified because Homeovox did not cause death of animals at introduction of the maximum allowable volumes and maximum allowable concentrations. The morphological view of the internal organs, detected during pathoanatomical dissection of all experimental animals, did not differ from that observed in control animals.Conclusion. It was determined that Homeovox at oral and intraperitoneal introduction concerns to practically non-toxic substances. According to classification Sidorov KK this homeopathic tablets may be related to 5th toxicity class. According to GOST 12.1.007-76 Homeovox may be related to 4th danger class.ΠΡΠ΅Π½ΠΊΠ° ΠΎΡΡΡΠΎΠΉ ΡΠΎΠΊΡΠΈΡΠ½ΠΎΡΡΠΈ ΡΠ²Π»ΡΠ΅ΡΡΡ Π½Π΅ΠΎΠ±Ρ
ΠΎΠ΄ΠΈΠΌΡΠΌ ΡΡΠ°ΠΏΠΎΠΌ Π΄ΠΎΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ ΡΠ°Π±Π»Π΅ΡΠΎΠΊ ΠΠΎΠΌΠ΅ΠΎΠ²ΠΎΠΊΡ Π³ΠΎΠΌΠ΅ΠΎΠΏΠ°ΡΠΈΡΠ΅ΡΠΊΠΈΡ
Π΄Π»Ρ Π»Π΅ΡΠ΅Π½ΠΈΡ Π»Π°ΡΠΈΠ½Π³ΠΈΡΠΎΠ² ΠΈ Π½Π°ΡΡΡΠ΅Π½ΠΈΠΉ Π³ΠΎΠ»ΠΎΡΠ°.Π¦Π΅Π»Ρ Π½Π°ΡΡΠΎΡΡΠ΅ΠΉ ΡΠ°Π±ΠΎΡΡ - ΠΈΠ·ΡΡΠ΅Π½ΠΈΠ΅ ΠΎΡΡΡΠΎΠΉ ΡΠΎΠΊΡΠΈΡΠ½ΠΎΡΡΠΈ ΡΠ°Π±Π»Π΅ΡΠΎΠΊ ΠΠΎΠΌΠ΅ΠΎΠ²ΠΎΠΊΡ Π³ΠΎΠΌΠ΅ΠΎΠΏΠ°ΡΠΈΡΠ΅ΡΠΊΠΈΡ
.ΠΠ΅ΡΠΎΠ΄Ρ. ΠΠΎΠΌΠ΅ΠΎΠ²ΠΎΠΊΡ Π²Π²ΠΎΠ΄ΠΈΠ»ΠΈ ΠΎΠ΄Π½ΠΎΠΊΡΠ°ΡΠ½ΠΎ ΠΏΠ΅ΡΠΎΡΠ°Π»ΡΠ½ΠΎ ΠΈ Π²Π½ΡΡΡΠΈΠ±ΡΡΡΠΈΠ½Π½ΠΎ ΠΌΡΡΠ°ΠΌ ΠΈ ΠΊΡΡΡΠ°ΠΌ Π² ΠΌΠ°ΠΊΡΠΈΠΌΠ°Π»ΡΠ½ΠΎ Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΡΡ
ΠΎΠ±ΡΡΠΌΠ°Ρ
Π΄Π»Ρ ΠΊΠ°ΠΆΠ΄ΠΎΠ³ΠΎ ΠΈΠ· ΡΠΏΠΎΡΠΎΠ±ΠΎΠ² Π²Π²Π΅Π΄Π΅Π½ΠΈΡ ΠΈ Π΄Π»Ρ ΠΊΠ°ΠΆΠ΄ΠΎΠ³ΠΎ ΠΈΠ· Π²ΠΈΠ΄ΠΎΠ² ΠΆΠΈΠ²ΠΎΡΠ½ΡΡ
, Π² ΠΌΠ°ΠΊΡΠΈΠΌΠ°Π»ΡΠ½ΠΎ Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΡΡ
ΠΊΠΎΠ½ΡΠ΅Π½ΡΡΠ°ΡΠΈΡΡ
. ΠΠΈΠ²ΠΎΡΠ½ΡΠ΅ ΠΊΠΎΠ½ΡΡΠΎΠ»ΡΠ½ΡΡ
Π³ΡΡΠΏΠΏ ΠΏΠΎΠ»ΡΡΠΈΠ»ΠΈ ΡΠΊΠ²ΠΈΠ²Π°Π»Π΅Π½ΡΠ½ΡΠΉ ΠΎΠ±ΡΡΠΌ 1 % ΡΠ°ΡΡΠ²ΠΎΡΠ° ΠΊΡΠ°Ρ
ΠΌΠ°Π»Π°. Π Π΅Π³ΠΈΡΡΡΠΈΡΠΎΠ²Π°Π»ΠΈΡΡ ΡΡΠΎΠΊΠΈ ΡΠ°Π·Π²ΠΈΡΠΈΡ ΠΈΠ½ΡΠΎΠΊΡΠΈΠΊΠ°ΡΠΈΠΈ ΠΆΠΈΠ²ΠΎΡΠ½ΡΡ
Ρ ΠΏΠΎΠ΄ΡΠΎΠ±Π½ΡΠΌ ΠΎΠΏΠΈΡΠ°Π½ΠΈΠ΅ΠΌ Π½Π°Π±Π»ΡΠ΄Π°Π΅ΠΌΠΎΠΉ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΊΠ°ΡΡΠΈΠ½Ρ. ΠΠ²ΡΠ°Π½Π°Π·ΠΈΡ ΠΈ ΠΏΠ°ΡΠΎΠ»ΠΎΠ³ΠΎΠ°Π½Π°ΡΠΎΠΌΠΈΡΠ΅ΡΠΊΠΎΠ΅ Π²ΡΠΊΡΡΡΠΈΠ΅ ΠΏΡΠΎΠ²ΠΎΠ΄ΠΈΠ»ΠΈ ΡΠ΅ΡΠ΅Π· 14 ΡΡΡ ΠΏΠΎΡΠ»Π΅ Π²Π²Π΅Π΄Π΅Π½ΠΈΡ ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΠ°.Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ. ΠΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΠ΅ ΡΡΠ΅Π΄Π½ΠΈΡ
ΡΠΌΠ΅ΡΡΠ΅Π»ΡΠ½ΡΡ
Π΄ΠΎΠ· Π½Π΅ ΠΏΡΠ΅Π΄ΡΡΠ°Π²Π»ΡΠ»ΠΎΡΡ Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΡΠΌ ΠΈΠ·-Π·Π° ΠΎΡΡΡΡΡΡΠ²ΠΈΡ Π³ΠΈΠ±Π΅Π»ΠΈ ΠΆΠΈΠ²ΠΎΡΠ½ΡΡ
Π² ΡΡΠ»ΠΎΠ²ΠΈΡΡ
Π΄ΠΎΡΡΠΈΠΆΠ΅Π½ΠΈΡ ΠΌΠ°ΠΊΡΠΈΠΌΠ°Π»ΡΠ½ΠΎ Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΡΡ
ΠΊΠΎΠ½ΡΠ΅Π½ΡΡΠ°ΡΠΈΠΉ ΠΈ ΠΌΠ°ΠΊΡΠΈΠΌΠ°Π»ΡΠ½ΠΎ Π΄ΠΎΠΏΡΡΡΠΈΠΌΡΡ
ΠΎΠ±ΡΡΠΌΠΎΠ² Π²Π²Π΅Π΄Π΅Π½ΠΈΡ. ΠΠΎΡΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠ°Ρ ΠΊΠ°ΡΡΠΈΠ½Π° Π²Π½ΡΡΡΠ΅Π½Π½ΠΈΡ
ΠΎΡΠ³Π°Π½ΠΎΠ², ΠΎΠ±Π½Π°ΡΡΠΆΠ΅Π½Π½Π°Ρ ΠΏΡΠΈ ΠΏΠ°ΡΠΎΠ»ΠΎΠ³ΠΎΠ°Π½Π°ΡΠΎΠΌΠΈΡΠ΅ΡΠΊΠΎΠΌ Π²ΡΠΊΡΡΡΠΈΠΈ Π²ΡΠ΅Ρ
ΡΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ°Π»ΡΠ½ΡΡ
ΠΆΠΈΠ²ΠΎΡΠ½ΡΡ
, Π½Π΅ ΠΎΡΠ»ΠΈΡΠ°Π»Π°ΡΡ ΠΎΡ ΡΠ°ΠΊΠΎΠ²ΠΎΠΉ, Π½Π°Π±Π»ΡΠ΄Π°Π΅ΠΌΠΎΠΉ Ρ ΠΊΠΎΠ½ΡΡΠΎΠ»ΡΠ½ΡΡ
ΠΆΠΈΠ²ΠΎΡΠ½ΡΡ
.ΠΠ°ΠΊΠ»ΡΡΠ΅Π½ΠΈΠ΅. Π£ΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½ΠΎ, ΡΡΠΎ ΠΠΎΠΌΠ΅ΠΎΠ²ΠΎΠΊΡ ΠΏΡΠΈ ΠΏΠ΅ΡΠΎΡΠ°Π»ΡΠ½ΠΎΠΌ ΠΈ Π²Π½ΡΡΡΠΈΠ±ΡΡΡΠΈΠ½Π½ΠΎΠΌ Π²Π²Π΅Π΄Π΅Π½ΠΈΠΈ ΡΠ²Π»ΡΠ΅ΡΡΡ ΠΏΡΠ°ΠΊΡΠΈΡΠ΅ΡΠΊΠΈ Π½Π΅ΡΠΎΠΊΡΠΈΡΠ½ΡΠΌ Π²Π΅ΡΠ΅ΡΡΠ²ΠΎΠΌ ΠΈ ΠΏΠΎ ΠΊΠ»Π°ΡΡΠΈΡΠΈΠΊΠ°ΡΠΈΠΈ Π‘ΠΈΠ΄ΠΎΡΠΎΠ²Π° Π.Π. (1973 Π³.) ΠΌΠΎΠΆΠ΅Ρ Π±ΡΡΡ ΠΎΡΠ½Π΅ΡΡΠ½ ΠΊ 5 ΠΊΠ»Π°ΡΡΡ ΡΠΎΠΊΡΠΈΡΠ½ΠΎΡΡΠΈ. Π ΡΠΎΠΎΡΠ²Π΅ΡΡΡΠ²ΠΈΠΈ Ρ ΠΠΠ‘Π’ΠΎΠΌ 12.1.007-76 ΠΠΎΠΌΠ΅ΠΎΠ²ΠΎΠΊΡ ΠΎΡΠ½ΠΎΡΠΈΡΡΡ ΠΊ 4 ΠΊΠ»Π°ΡΡΡ ΠΎΠΏΠ°ΡΠ½ΠΎΡΡΠΈ Π΄Π»Ρ ΠΏΠ΅ΡΠΎΡΠ°Π»ΡΠ½ΠΎΠ³ΠΎ ΡΠΏΠΎΡΠΎΠ±Π° Π²Π²Π΅Π΄Π΅Π½ΠΈΡ
ΠΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ Ρ ΡΠΎΠ½ΠΈΡΠ΅ΡΠΊΠΎΠΉ ΡΠΎΠΊΡΠΈΡΠ½ΠΎΡΡΠΈ ΡΠ°Π±Π»Π΅ΡΠΎΠΊ ΠΠΎΠΌΠ΅ΠΎΠ²ΠΎΠΊΡ
Relevance. Assessment of chronic toxicity is a necessary stage of preclinical research a tablets Homeovox homeopathic. The aim of present research is study of chronic toxicity of a tablets Homeovox homeopathic.Methods. Homeovox was administered orally to males and females of rats and rabbits in doses of 100 and 1 000 mg / kg for three months. The appearance and the general state of animals were observed, the dynamics of body weight, feed and water consumption, behavioral reactions, rectal temperature, state of the cardiovascular system (electrocardiography, blood pressure measurement) were evaluated, hematological, biochemical and pathomorphological examinations were conducted to determine possible toxic effects and their reversibility, possible target organs and local irritant effect.Results. Parameters registered in the conducted studies did not get out the limits of the reference values for these species of animals. Homeovox did not cause any regular changes in the structure of the internal organs of rats and rabbits.Conclusion. Homeovox, administered to rats and rabbits for three months orally daily in doses of 100 and 1 000 mg / kg, did not demonstrate toxic effects and local irritant effect.Β ΠΠΊΡΡΠ°Π»ΡΠ½ΠΎΡΡΡ. ΠΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ Ρ
ΡΠΎΠ½ΠΈΡΠ΅ΡΠΊΠΎΠΉ ΡΠΎΠΊΡΠΈΡΠ½ΠΎΡΡΠΈ ΡΠ²Π»ΡΠ΅ΡΡΡ Π½Π΅ΠΎΠ±Ρ
ΠΎΠ΄ΠΈΠΌΡΠΌ ΡΡΠ°ΠΏΠΎΠΌ Π΄ΠΎΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ ΡΠ°Π±Π»Π΅ΡΠΎΠΊ ΠΠΎΠΌΠ΅ΠΎΠ²ΠΎΠΊΡ Π³ΠΎΠΌΠ΅ΠΎΠΏΠ°ΡΠΈΡΠ΅ΡΠΊΠΈΡ
, ΠΏΡΠΈΠΌΠ΅Π½ΡΠ΅ΠΌΡΡ
Π΄Π»Ρ Π»Π΅ΡΠ΅Π½ΠΈΡ Π»Π°ΡΠΈΠ½Π³ΠΈΡΠΎΠ² ΡΠ°Π·Π»ΠΈΡΠ½ΠΎΠΉ ΡΡΠΈΠΎΠ»ΠΎΠ³ΠΈΠΈ.Π¦Π΅Π»ΡΡ Π½Π°ΡΡΠΎΡΡΠ΅ΠΉ ΡΠ°Π±ΠΎΡΡ ΡΠ²ΠΈΠ»ΠΎΡΡ ΠΈΠ·ΡΡΠ΅Π½ΠΈΠ΅ Ρ
ΡΠΎΠ½ΠΈΡΠ΅ΡΠΊΠΎΠΉ ΡΠΎΠΊΡΠΈΡΠ½ΠΎΡΡΠΈ ΡΠ°Π±Π»Π΅ΡΠΎΠΊ ΠΠΎΠΌΠ΅ΠΎΠ²ΠΎΠΊΡ Π³ΠΎΠΌΠ΅ΠΎΠΏΠ°ΡΠΈΡΠ΅ΡΠΊΠΈΡ
.ΠΠ΅ΡΠΎΠ΄Ρ. ΠΠΎΠΌΠ΅ΠΎΠ²ΠΎΠΊΡ Π²Π²ΠΎΠ΄ΠΈΠ»ΠΈ Π΅ΠΆΠ΅Π΄Π½Π΅Π²Π½ΠΎ ΡΠ°ΠΌΡΠ°ΠΌ ΠΈ ΡΠ°ΠΌΠΊΠ°ΠΌ ΠΊΡΡΡ ΠΈ ΠΊΡΠΎΠ»ΠΈΠΊΠΎΠ² ΠΏΠ΅ΡΠΎΡΠ°Π»ΡΠ½ΠΎ Π² Π΄ΠΎΠ·Π°Ρ
100 ΠΈ 1 000 ΠΌΠ³/ΠΊΠ³, Π² ΡΠ΅ΡΠ΅Π½ΠΈΠ΅ ΡΡΡΡ
ΠΌΠ΅ΡΡΡΠ΅Π². ΠΠ°Π±Π»ΡΠ΄Π°Π»ΠΈ Π·Π° Π²Π½Π΅ΡΠ½ΠΈΠΌ Π²ΠΈΠ΄ΠΎΠΌ ΠΈ ΠΎΠ±ΡΠΈΠΌ ΡΠΎΡΡΠΎΡΠ½ΠΈΠ΅ΠΌ ΠΆΠΈΠ²ΠΎΡΠ½ΡΡ
, ΠΎΡΠ΅Π½ΠΈΠ²Π°Π»ΠΈ Π΄ΠΈΠ½Π°ΠΌΠΈΠΊΡ ΠΌΠ°ΡΡΡ ΡΠ΅Π»Π°, ΠΏΠΎΡΡΠ΅Π±Π»Π΅Π½ΠΈΠ΅ ΠΊΠΎΡΠΌΠ° ΠΈ Π²ΠΎΠ΄Ρ, ΠΏΠΎΠ²Π΅Π΄Π΅Π½ΡΠ΅ΡΠΊΠΈΠ΅ ΡΠ΅Π°ΠΊΡΠΈΠΈ, ΡΠ΅ΠΊΡΠ°Π»ΡΠ½ΡΡ ΡΠ΅ΠΌΠΏΠ΅ΡΠ°ΡΡΡΡ, ΡΠΎΡΡΠΎΡΠ½ΠΈΠ΅ ΡΠ΅ΡΠ΄Π΅ΡΠ½ΠΎ-ΡΠΎΡΡΠ΄ΠΈΡΡΠΎΠΉ ΡΠΈΡΡΠ΅ΠΌΡ (ΡΠ»Π΅ΠΊΡΡΠΎΠΊΠ°ΡΠ΄ΠΈΠΎΠ³ΡΠ°ΡΠΈΡ, ΠΈΠ·ΠΌΠ΅ΡΠ΅Π½ΠΈΠ΅ Π°ΡΡΠ΅ΡΠΈΠ°Π»ΡΠ½ΠΎΠ³ΠΎ Π΄Π°Π²Π»Π΅Π½ΠΈΡ), ΠΏΡΠΎΠ²ΠΎΠ΄ΠΈΠ»ΠΈ Π³Π΅ΠΌΠ°ΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΠ΅, Π±ΠΈΠΎΡ
ΠΈΠΌΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΠΈ ΠΏΠ°ΡΠΎΠΌΠΎΡΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ Π΄Π»Ρ ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΡ Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΡΡ
ΡΠΎΠΊΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΡΡΠ΅ΠΊΡΠΎΠ² ΠΈ ΠΈΡ
ΠΎΠ±ΡΠ°ΡΠΈΠΌΠΎΡΡΠΈ, Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΡΡ
ΠΎΡΠ³Π°Π½ΠΎΠ²-ΠΌΠΈΡΠ΅Π½Π΅ΠΉ ΠΈ ΠΌΠ΅ΡΡΠ½ΠΎΠ³ΠΎ ΡΠ°Π·Π΄ΡΠ°ΠΆΠ°ΡΡΠ΅Π³ΠΎ Π΄Π΅ΠΉΡΡΠ²ΠΈΡ.Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ. ΠΠ°ΡΠ°ΠΌΠ΅ΡΡΡ, ΡΠ΅Π³ΠΈΡΡΡΠΈΡΡΠ΅ΠΌΡΠ΅ Π² ΠΏΡΠΎΠ²Π΅Π΄ΡΠ½Π½ΡΡ
ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡΡ
, Π½Π΅ Π²ΡΡ
ΠΎΠ΄ΠΈΠ»ΠΈ Π·Π° ΠΏΡΠ΅Π΄Π΅Π»Ρ ΡΠ΅ΡΠ΅ΡΠ΅Π½ΡΠ½ΡΡ
Π·Π½Π°ΡΠ΅Π½ΠΈΠΉ Π΄Π»Ρ Π΄Π°Π½Π½ΡΡ
Π²ΠΈΠ΄ΠΎΠ² ΠΆΠΈΠ²ΠΎΡΠ½ΡΡ
. ΠΠΎΠΌΠ΅ΠΎΠ²ΠΎΠΊΡ Π² ΡΡΠ»ΠΎΠ²ΠΈΡΡ
Π½Π°ΡΡΠΎΡΡΠ΅Π³ΠΎ ΡΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ° Π½Π΅ Π²ΡΠ·ΡΠ²Π°Π» Π·Π°ΠΊΠΎΠ½ΠΎΠΌΠ΅ΡΠ½ΡΡ
ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΠΉ ΡΡΡΡΠΊΡΡΡΡ Π²Π½ΡΡΡΠ΅Π½Π½ΠΈΡ
ΠΎΡΠ³Π°Π½ΠΎΠ² ΠΊΡΡΡ ΠΈ ΠΊΡΠΎΠ»ΠΈΠΊΠΎΠ².ΠΠ°ΠΊΠ»ΡΡΠ΅Π½ΠΈΠ΅. ΠΠΎΠΌΠ΅ΠΎΠ²ΠΎΠΊΡ, Π²Π²ΠΎΠ΄ΠΈΠΌΡΠΉ ΠΊΡΡΡΠ°ΠΌ ΠΈ ΠΊΡΠΎΠ»ΠΈΠΊΠ°ΠΌ Π² ΡΠ΅ΡΠ΅Π½ΠΈΠ΅ ΡΡΡΡ
ΠΌΠ΅ΡΡΡΠ΅Π² ΠΏΠ΅ΡΠΎΡΠ°Π»ΡΠ½ΠΎ Π΅ΠΆΠ΅Π΄Π½Π΅Π²Π½ΠΎ Π² Π΄ΠΎΠ·Π°Ρ
100 ΠΈ 1 000 ΠΌΠ³/ΠΊΠ³, Π½Π΅ ΠΏΡΠΎΠ΄Π΅ΠΌΠΎΠ½ΡΡΡΠΈΡΠΎΠ²Π°Π» ΡΠΎΠΊΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΡΡΠ΅ΠΊΡΠΎΠ² ΠΈ ΠΌΠ΅ΡΡΠ½ΠΎΠ³ΠΎ ΡΠ°Π·Π΄ΡΠ°ΠΆΠ°ΡΡΠ΅Π³ΠΎ Π΄Π΅ΠΉΡΡΠ²ΠΈΡ. ΠΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅, ΠΏΡΠΎΠ²Π΅Π΄ΡΠ½Π½ΠΎΠ΅ Π² ΡΠΎΠΎΡΠ²Π΅ΡΡΡΠ²ΠΈΠΈ Ρ ΠΌΠ΅ΡΠΎΠ΄ΠΈΡΠ΅ΡΠΊΠΈΠΌΠΈ ΡΠ΅ΠΊΠΎΠΌΠ΅Π½Π΄Π°ΡΠΈΡΠΌΠΈ, Π½Π΅ ΡΡΡΠ°Π½ΠΎΠ²ΠΈΠ»ΠΎ Π΄Π°Π½Π½ΡΡ
, ΠΏΡΠ΅ΠΏΡΡΡΡΠ²ΡΡΡΠΈΡ
ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΎΠΌΡ ΠΈΡΠΏΡΡΠ°Π½ΠΈΡ ΡΠ°Π±Π»Π΅ΡΠΎΠΊ ΠΠΎΠΌΠ΅ΠΎΠ²ΠΎΠΊΡ, ΠΏΠΎΠΊΡΡΡΡΡ
ΠΎΠ±ΠΎΠ»ΠΎΡΠΊΠΎΠΉ Π³ΠΎΠΌΠ΅ΠΎΠΏΠ°ΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ ΠΎΡΡΡΠΎΠΉ ΡΠΎΠΊΡΠΈΡΠ½ΠΎΡΡΠΈ ΠΠΠ-298
Assessment of acute toxicity is a necessary stage of preclinical research of the substance GIZh-298. The aim of present research is study of acute toxicity GIZh-298. Methods. GIZh-298 was administered once intraperitoneally to mice at doses 200-330 mg/kg. Equivalent volume of 1 % starch solution was administered to animals of the control groups. Periods of intoxication and death of animals with a detailed description of the observed clinical picture were registered. Euthanasia and pathoanatomical dissection were performed 14 days after drug administration. Results. The median lethal doses were identified: LD50 = 299,6 (279,7 β 320,8) mg/kg in female mice, LD50 = 302,3 (281,5 β 324,6) mg/kg in male mice at intraperitoneal introduction. The morphological view of the internal organs, detected during pathoanatomical dissection of all surviving experimental animals, did not differ from that observed in control animals. Conclusion. It was determined that GIZh-298 at intraperitoneal introduction concerns to low-toxic substances. According to classification Sidorov K.K. GIZh-298 may be related to 4th toxicity class.ΠΠΊΡΡΠ°Π»ΡΠ½ΠΎΡΡΡ. ΠΡΠ΅Π½ΠΊΠ° ΠΎΡΡΡΠΎΠΉ ΡΠΎΠΊΡΠΈΡΠ½ΠΎΡΡΠΈ ΡΠ²Π»ΡΠ΅ΡΡΡ Π½Π΅ΠΎΠ±Ρ
ΠΎΠ΄ΠΈΠΌΡΠΌ ΡΡΠ°ΠΏΠΎΠΌ Π΄ΠΎΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ ΡΠ°ΡΠΌΠ°ΠΊΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠΉ ΡΡΠ±ΡΡΠ°Π½ΡΠΈΠΈ ΠΠΠ-298. Π¦Π΅Π»Ρ Π½Π°ΡΡΠΎΡΡΠ΅ΠΉ ΡΠ°Π±ΠΎΡΡ β ΠΈΠ·ΡΡΠ΅Π½ΠΈΠ΅ ΠΎΡΡΡΠΎΠΉ ΡΠΎΠΊΡΠΈΡΠ½ΠΎΡΡΠΈ ΡΡΠ±ΡΡΠ°Π½ΡΠΈΠΈ ΠΠΠ-298. ΠΠ΅ΡΠΎΠ΄Ρ. ΠΠΠ-298 Π²Π²ΠΎΠ΄ΠΈΠ»ΠΈ ΠΎΠ΄Π½ΠΎΠΊΡΠ°ΡΠ½ΠΎ Π²Π½ΡΡΡΠΈΠ±ΡΡΡΠΈΠ½Π½ΠΎ ΠΌΡΡΠ°ΠΌ Π² Π΄ΠΎΠ·Π°Ρ
200β330 ΠΌΠ³/ΠΊΠ³. ΠΠΈΠ²ΠΎΡΠ½ΡΠΌ ΠΊΠΎΠ½ΡΡΠΎΠ»ΡΠ½ΡΡ
Π³ΡΡΠΏΠΏ Π²Π²ΠΎΠ΄ΠΈΠ»ΠΈ ΠΏΠΎ 1 ΠΌΠ» 1 % ΡΠ°ΡΡΠ²ΠΎΡΠ° ΠΊΡΠ°Ρ
ΠΌΠ°Π»Π°. Π Π΅Π³ΠΈΡΡΡΠΈΡΠΎΠ²Π°Π»ΠΈ ΡΡΠΎΠΊΠΈ ΡΠ°Π·Π²ΠΈΡΠΈΡ ΠΈΠ½ΡΠΎΠΊΡΠΈΠΊΠ°ΡΠΈΠΈ ΠΈ Π³ΠΈΠ±Π΅Π»ΠΈ ΠΆΠΈΠ²ΠΎΡΠ½ΡΡ
Ρ ΠΏΠΎΠ΄ΡΠΎΠ±Π½ΡΠΌ ΠΎΠΏΠΈΡΠ°Π½ΠΈΠ΅ΠΌ Π½Π°Π±Π»ΡΠ΄Π°Π΅ΠΌΠΎΠΉ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΊΠ°ΡΡΠΈΠ½Ρ. ΠΠ²ΡΠ°Π½Π°Π·ΠΈΡ ΠΈ ΠΏΠ°ΡΠΎΠ»ΠΎΠ³ΠΎΠ°Π½Π°ΡΠΎΠΌΠΈΡΠ΅ΡΠΊΠΎΠ΅ Π²ΡΠΊΡΡΡΠΈΠ΅ ΠΏΡΠΎΠ²ΠΎΠ΄ΠΈΠ»ΠΈ ΡΠ΅ΡΠ΅Π· 14 ΡΡΡΠΎΠΊ ΠΏΠΎΡΠ»Π΅ Π²Π²Π΅Π΄Π΅Π½ΠΈΡ ΡΡΠ±ΡΡΠ°Π½ΡΠΈΠΈ ΠΠΠ-298. Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ. ΠΡΠ»ΠΈ ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½Ρ ΡΡΠ΅Π΄Π½Π΅Π»Π΅ΡΠ°Π»ΡΠ½ΡΠ΅ Π΄ΠΎΠ·Ρ ΠΏΡΠΈ Π²Π½ΡΡΡΠΈΠ±ΡΡΡΠΈΠ½Π½ΠΎΠΌ Π²Π²Π΅Π΄Π΅Π½ΠΈΠΈ: LD50 = 299,6 (279,7 β 320,8) ΠΌΠ³/ΠΊΠ³ Ρ ΡΠ°ΠΌΠΎΠΊ ΠΌΡΡΠ΅ΠΉ, LD50 = 302,3 (281,5 β 324,6) ΠΌΠ³/ΠΊΠ³ Ρ ΡΠ°ΠΌΡΠΎΠ² ΠΌΡΡΠ΅ΠΉ. ΠΠΎΡΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠ°Ρ ΠΊΠ°ΡΡΠΈΠ½Π° Π²Π½ΡΡΡΠ΅Π½Π½ΠΈΡ
ΠΎΡΠ³Π°Π½ΠΎΠ², ΠΎΠ±Π½Π°ΡΡΠΆΠ΅Π½Π½Π°Ρ ΠΏΡΠΈ ΠΏΠ°ΡΠΎΠ»ΠΎΠ³ΠΎΠ°Π½Π°ΡΠΎΠΌΠΈΡΠ΅ΡΠΊΠΎΠΌ Π²ΡΠΊΡΡΡΠΈΠΈ Π²ΡΠ΅Ρ
Π²ΡΠΆΠΈΠ²ΡΠΈΡ
ΡΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ°Π»ΡΠ½ΡΡ
ΠΆΠΈΠ²ΠΎΡΠ½ΡΡ
, Π½Π΅ ΠΎΡΠ»ΠΈΡΠ°Π»Π°ΡΡ ΠΎΡ ΡΠ°ΠΊΠΎΠ²ΠΎΠΉ, Π½Π°Π±Π»ΡΠ΄Π°Π΅ΠΌΠΎΠΉ Ρ ΠΊΠΎΠ½ΡΡΠΎΠ»ΡΠ½ΡΡ
ΠΆΠΈΠ²ΠΎΡΠ½ΡΡ
. ΠΠ°ΠΊΠ»ΡΡΠ΅Π½ΠΈΠ΅. ΠΠΠ-298 ΠΏΡΠΈ Π²Π½ΡΡΡΠΈΠ±ΡΡΡΠΈΠ½Π½ΠΎΠΌ Π²Π²Π΅Π΄Π΅Π½ΠΈΠΈ ΡΠ²Π»ΡΠ΅ΡΡΡ ΠΌΠ°Π»ΠΎΡΠΎΠΊΡΠΈΡΠ½ΡΠΌ Π²Π΅ΡΠ΅ΡΡΠ²ΠΎΠΌ ΠΈ ΠΏΠΎ ΠΊΠ»Π°ΡΡΠΈΡΠΈΠΊΠ°ΡΠΈΠΈ Π‘ΠΈΠ΄ΠΎΡΠΎΠ²Π° Π.Π. (1973 Π³.) ΠΎΡΠ½ΠΎΡΠΈΡΡΡ ΠΊ 4 ΠΊΠ»Π°ΡΡΡ ΡΠΎΠΊΡΠΈΡΠ½ΠΎΡΡΠΈ
ΠΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ Ρ ΡΠΎΠ½ΠΈΡΠ΅ΡΠΊΠΎΠΉ ΡΠΎΠΊΡΠΈΡΠ½ΠΎΡΡΠΈ ΠΏΠΎΡΠ΅Π½ΡΠΈΠ°Π»ΡΠ½ΠΎΠ³ΠΎ Π°Π½ΠΊΡΠΈΠΎΠ»ΠΈΡΠΈΠΊΠ° ΠΠΠ-1
Relevance. Assessment of chronic toxicity is a necessary stage of preclinical research of a newly synthesized pharmacological substance GML-1 having anxiolytic activity. The aim of present research is study of chronic toxicity of tablet form GML-1. Methods. Tablet mass of GML-1 was administered orally to males and females of rats and rabbits in doses of 1 and 10 mg / kg for one month. The appearance and the general state of animals were observed, the dynamics of body weight, feed and water consumption, behavioral reactions, rectal temperature, state of the cardiovascular system (electrocardiography, blood pressure measurement) were evaluated, hematological, biochemical and pathomorphological examinations were conducted to determine possible toxic effects and their reversibility, possible target organs and local irritant effect. Results. Parameters registered in the conducted studies did not get out the limits of the reference values for these species of animals. GML-1 did not cause any regular changes in the structure of the internal organs of rats and rabbits. Conclusion. GML-1, administered to rats and rabbits for one month orally daily in doses of 1 and 10 mg / kg, did not demonstrate toxic effects and local irritant effect.ΠΠΊΡΡΠ°Π»ΡΠ½ΠΎΡΡΡ. ΠΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ Ρ
ΡΠΎΠ½ΠΈΡΠ΅ΡΠΊΠΎΠΉ ΡΠΎΠΊΡΠΈΡΠ½ΠΎΡΡΠΈ ΡΠ²Π»ΡΠ΅ΡΡΡ Π½Π΅ΠΎΠ±Ρ
ΠΎΠ΄ΠΈΠΌΡΠΌ ΡΡΠ°ΠΏΠΎΠΌ Π΄ΠΎΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΎΡΠ΅Π½ΠΊΠΈ Π²Π½ΠΎΠ²Ρ ΡΠΈΠ½ΡΠ΅Π·ΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠ³ΠΎ ΡΠ°ΡΠΌΠ°ΠΊΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ Π²Π΅ΡΠ΅ΡΡΠ²Π° ΠΠΠ-1, ΠΎΠ±Π»Π°Π΄Π°ΡΡΠ΅Π³ΠΎ Π°Π½ΠΊΡΠΈΠΎΠ»ΠΈΡΠΈΡΠ΅ΡΠΊΠΎΠΉ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡΡ. Π¦Π΅Π»ΡΡ Π½Π°ΡΡΠΎΡΡΠ΅ΠΉ ΡΠ°Π±ΠΎΡΡ ΡΡΠ°Π»ΠΎ ΠΈΠ·ΡΡΠ΅Π½ΠΈΠ΅ Ρ
ΡΠΎΠ½ΠΈΡΠ΅ΡΠΊΠΎΠΉ ΡΠΎΠΊΡΠΈΡΠ½ΠΎΡΡΠΈ ΡΠ°Π±Π»Π΅ΡΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠΉ ΡΠΎΡΠΌΡ ΠΠΠ-1. ΠΠ΅ΡΠΎΠ΄Ρ. ΠΠΠ-1 Π² Π²ΠΈΠ΄Π΅ ΡΠ°Π±Π»Π΅ΡΠΎΡΠ½ΠΎΠΉ ΠΌΠ°ΡΡΡ Π΅ΠΆΠ΅Π΄Π½Π΅Π²Π½ΠΎ Π²Π²ΠΎΠ΄ΠΈΠ»ΠΈ ΡΠ°ΠΌΡΠ°ΠΌ ΠΈ ΡΠ°ΠΌΠΊΠ°ΠΌ ΠΊΡΡΡ ΠΈ ΠΊΡΠΎΠ»ΠΈΠΊΠΎΠ² ΠΏΠ΅ΡΠΎΡΠ°Π»ΡΠ½ΠΎ Π² Π΄ΠΎΠ·Π°Ρ
1 ΠΈ 10 ΠΌΠ³/ΠΊΠ³, Π² ΡΠ΅ΡΠ΅Π½ΠΈΠΈ ΠΎΠ΄Π½ΠΎΠ³ΠΎ ΠΌΠ΅ΡΡΡΠ°. ΠΠ°Π±Π»ΡΠ΄Π°Π»ΠΈ Π·Π° Π²Π½Π΅ΡΠ½ΠΈΠΌ Π²ΠΈΠ΄ΠΎΠΌ ΠΈ ΠΎΠ±ΡΠΈΠΌ ΡΠΎΡΡΠΎΡΠ½ΠΈΠ΅ΠΌ ΠΆΠΈΠ²ΠΎΡΠ½ΡΡ
, ΠΎΡΠ΅Π½ΠΈΠ²Π°Π»ΠΈ Π΄ΠΈΠ½Π°ΠΌΠΈΠΊΡ ΠΌΠ°ΡΡΡ ΡΠ΅Π»Π°, ΠΏΠΎΡΡΠ΅Π±Π»Π΅Π½ΠΈΠ΅ ΠΊΠΎΡΠΌΠ° ΠΈ Π²ΠΎΠ΄Ρ, ΠΏΠΎΠ²Π΅Π΄Π΅Π½ΡΠ΅ΡΠΊΠΈΠ΅ ΡΠ΅Π°ΠΊΡΠΈΠΈ, ΡΠ΅ΠΊΡΠ°Π»ΡΠ½ΡΡ ΡΠ΅ΠΌΠΏΠ΅ΡΠ°ΡΡΡΡ, ΡΠΎΡΡΠΎΡΠ½ΠΈΠ΅ ΡΠ΅ΡΠ΄Π΅ΡΠ½ΠΎ-ΡΠΎΡΡΠ΄ΠΈΡΡΠΎΠΉ ΡΠΈΡΡΠ΅ΠΌΡ (ΡΠ»Π΅ΠΊΡΡΠΎΠΊΠ°ΡΠ΄ΠΈΠΎΠ³ΡΠ°ΡΠΈΡ, ΠΈΠ·ΠΌΠ΅ΡΠ΅Π½ΠΈΠ΅ Π°ΡΡΠ΅ΡΠΈΠ°Π»ΡΠ½ΠΎΠ³ΠΎ Π΄Π°Π²Π»Π΅Π½ΠΈΡ), ΠΏΡΠΎΠ²ΠΎΠ΄ΠΈΠ»ΠΈ Π³Π΅ΠΌΠ°ΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΠ΅, Π±ΠΈΠΎΡ
ΠΈΠΌΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΠΈ ΠΏΠ°ΡΠΎΠΌΠΎΡΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ Π΄Π»Ρ ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΡ Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΡΡ
ΡΠΎΠΊΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΡΡΠ΅ΠΊΡΠΎΠ² ΠΈ ΠΈΡ
ΠΎΠ±ΡΠ°ΡΠΈΠΌΠΎΡΡΠΈ, Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΡΡ
ΠΎΡΠ³Π°Π½ΠΎΠ²-ΠΌΠΈΡΠ΅Π½Π΅ΠΉ ΠΈ ΠΌΠ΅ΡΡΠ½ΠΎΠ³ΠΎ ΡΠ°Π·Π΄ΡΠ°ΠΆΠ°ΡΡΠ΅Π³ΠΎ Π΄Π΅ΠΉΡΡΠ²ΠΈΡ. Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ. ΠΠ°ΡΠ°ΠΌΠ΅ΡΡΡ, ΡΠ΅Π³ΠΈΡΡΡΠΈΡΡΠ΅ΠΌΡΠ΅ Π² ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½Π½ΡΡ
ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡΡ
, Π½Π΅ Π²ΡΡ
ΠΎΠ΄ΠΈΠ»ΠΈ Π·Π° ΠΏΡΠ΅Π΄Π΅Π»Ρ ΡΠ΅ΡΠ΅ΡΠ΅Π½ΡΠ½ΡΡ
Π·Π½Π°ΡΠ΅Π½ΠΈΠΉ Π΄Π»Ρ Π΄Π°Π½Π½ΡΡ
Π²ΠΈΠ΄ΠΎΠ² ΠΆΠΈΠ²ΠΎΡΠ½ΡΡ
. ΠΠΠ-1 Π² ΡΡΠ»ΠΎΠ²ΠΈΡΡ
Π½Π°ΡΡΠΎΡΡΠ΅Π³ΠΎ ΡΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ° Π½Π΅ Π²ΡΠ·ΡΠ²Π°Π» Π·Π°ΠΊΠΎΠ½ΠΎΠΌΠ΅ΡΠ½ΡΡ
ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΠΉ Π²ΠΎ Π²Π½ΡΡΡΠ΅Π½Π½ΠΈΡ
ΠΎΡΠ³Π°Π½Π°Ρ
ΠΊΡΡΡ ΠΈ ΠΊΡΠΎΠ»ΠΈΠΊΠΎΠ². ΠΠ°ΠΊΠ»ΡΡΠ΅Π½ΠΈΠ΅. ΠΠΠ-1, Π²Π²ΠΎΠ΄ΠΈΠΌΡΠΉ ΠΊΡΡΡΠ°ΠΌ ΠΈ ΠΊΡΠΎΠ»ΠΈΠΊΠ°ΠΌ Π² ΡΠ΅ΡΠ΅Π½ΠΈΠ΅ ΠΎΠ΄Π½ΠΎΠ³ΠΎ ΠΌΠ΅ΡΡΡΠ° ΠΏΠ΅ΡΠΎΡΠ°Π»ΡΠ½ΠΎ Π΅ΠΆΠ΅Π΄Π½Π΅Π²Π½ΠΎ Π² Π΄ΠΎΠ·Π°Ρ
1 ΠΈ 10 ΠΌΠ³/ΠΊΠ³, Π½Π΅ ΠΏΡΠΎΠ΄Π΅ΠΌΠΎΠ½ΡΡΡΠΈΡΠΎΠ²Π°Π» ΡΠΎΠΊΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΡΡΠ΅ΠΊΡΠΎΠ² ΠΈ ΠΌΠ΅ΡΡΠ½ΠΎΠ³ΠΎ ΡΠ°Π·Π΄ΡΠ°ΠΆΠ°ΡΡΠ΅Π³ΠΎ Π΄Π΅ΠΉΡΡΠ²ΠΈΡ
ΠΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ ΠΎΡΡΡΠΎΠΉ ΡΠΎΠΊΡΠΈΡΠ½ΠΎΡΡΠΈ ΠΠΠ-290 Π½Π° ΠΌΡΡΠ°Ρ
Acute toxicity testing is a commonly accepted procedure for preclinical testing of the safety of potential drugs. The compound GIZh-290, which is a derivative of 4-phenylpyrrolidoneβ 2,6 - dimethylanilide (2-oxo-4-phenylpyrrolidine-1-yl) acetic acid and has a nootropic and anticonvulsant effect, was studied. The results obtained after a single oral and intraperitoneal administration to mice allow us to attribute GIZH-290 to the 4th class of toxicity β "lowtoxic substances". The study revealed the neurotoxic effects of GIZH-290, which may be due to the main pharmacological activity of the compound used in sublethal doses.ΠΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ ΠΎΡΡΡΠΎΠΉ ΡΠΎΠΊΡΠΈΡΠ½ΠΎΡΡΠΈ ΡΠ²Π»ΡΠ΅ΡΡΡ ΠΎΠ±ΡΠ΅ΠΏΡΠΈΠ½ΡΡΠΎΠΉ ΠΏΡΠΎΡΠ΅Π΄ΡΡΠΎΠΉ Π΄ΠΎΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ Π±Π΅Π·ΠΎΠΏΠ°ΡΠ½ΠΎΡΡΠΈ ΠΏΠΎΡΠ΅Π½ΡΠΈΠ°Π»ΡΠ½ΡΡ
Π»Π΅ΠΊΠ°ΡΡΡΠ². ΠΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΎ ΡΠΎΠ΅Π΄ΠΈΠ½Π΅Π½ΠΈΠ΅ ΠΠΠ-290, ΡΠ²Π»ΡΡΡΠ΅Π΅ ΠΏΡΠΎΠΈΠ·Π²ΠΎΠ΄Π½ΡΠΌ 4-ΡΠ΅Π½ΠΈΠ»Π»ΠΏΠΈΡΡΠΎΠ»ΠΈΠ΄ΠΎΠ½Π°β 2,6- Π΄ΠΈΠΌΠ΅ΡΠΈΠ»Π°Π½ΠΈΠ»ΠΈΠ΄ (2-ΠΎΠΊΡΠΎ-4-ΡΠ΅Π½ΠΈΠ»ΠΏΠΈΡΡΠΎΠ»ΠΈΠ΄ΠΈΠ½-1-ΠΈΠ») ΡΠΊΡΡΡΠ½ΠΎΠΉ ΠΊΠΈΡΠ»ΠΎΡΡ ΠΈ ΠΎΠ±Π»Π°Π΄Π°ΡΡΠ΅Π΅ Π½ΠΎΠΎΡΡΠΎΠΏΠ½ΡΠΌ ΠΈ ΠΏΡΠΎΡΠΈΠ²ΠΎΡΡΠ΄ΠΎΡΠΎΠΆΠ½ΡΠΌ Π΄Π΅ΠΉΡΡΠ²ΠΈΠ΅ΠΌ. Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ, ΠΏΠΎΠ»ΡΡΠ΅Π½Π½ΡΠ΅ ΠΏΠΎΡΠ»Π΅ ΠΎΠ΄Π½ΠΎΠΊΡΠ°ΡΠ½ΠΎΠ³ΠΎ ΠΏΠ΅ΡΠΎΡΠ°Π»ΡΠ½ΠΎΠ³ΠΎ ΠΈ Π²Π½ΡΡΡΠΈΠ±ΡΡΡΠΈΠ½Π½ΠΎΠ³ΠΎ Π²Π²Π΅Π΄Π΅Π½ΠΈΡ ΠΌΡΡΠ°ΠΌ, ΠΏΠΎΠ·Π²ΠΎΠ»ΡΡΡ ΠΎΡΠ½Π΅ΡΡΠΈ ΠΠΠ-290 ΠΊ 4 ΠΊΠ»Π°ΡΡΡ ΡΠΎΠΊΡΠΈΡΠ½ΠΎΡΡΠΈ β Β«ΠΌΠ°Π»ΠΎΡΠΎΠΊΡΠΈΡΠ½ΡΠ΅ Π²Π΅ΡΠ΅ΡΡΠ²Π°Β». Π Ρ
ΠΎΠ΄Π΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ Π²ΡΡΠ²Π»Π΅Π½Ρ Π½Π΅ΠΉΡΠΎΡΠΎΠΊΡΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΡΡΡΠ΅ΠΊΡΡ ΠΠΠ-290, ΠΊΠΎΡΠΎΡΡΠ΅ ΠΌΠΎΠ³ΡΡ Π±ΡΡΡ ΠΎΠ±ΡΡΠ»ΠΎΠ²Π»Π΅Π½Ρ ΠΎΡΠ½ΠΎΠ²Π½ΠΎΠΉ ΡΠ°ΡΠΌΠ°ΠΊΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠΉ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡΡ ΡΠΎΠ΅Π΄ΠΈΠ½Π΅Π½ΠΈΡ, ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½Π½ΠΎΠ³ΠΎ Π² ΡΡΠ±Π»Π΅ΡΠ°Π»ΡΠ½ΡΡ
Π΄ΠΎΠ·Π°Ρ
ΠΠ·ΡΡΠ΅Π½ΠΈΠ΅ ΠΎΡΡΡΠΎΠΉ ΡΠΎΠΊΡΠΈΡΠ½ΠΎΡΡΠΈ ΠΠΠ-298 Π½Π° Π±Π΅ΡΠΏΠΎΡΠΎΠ΄Π½ΡΡ Π±Π΅Π»ΡΡ ΠΌΡΡΠ°Ρ ΠΏΡΠΈ ΠΏΠ΅ΡΠΎΡΠ°Π»ΡΠ½ΠΎΠΌ Π²Π²Π΅Π΄Π΅Π½ΠΈΠΈ
Relevance. Assay of acute toxicity is a mandatory step in a preclinical safety study of medicines and pharmaceutical substances. The purpose of this study was to determine the parameters of acute toxicity of the substance GIZH-298. Methods. GIZH-298 was administered once orally to outbred mice of both sexes at doses of 350β550 mg/kg. Control mice received 0.5 ml of 1 % starch solution under the same conditions. During the experiment, the death of animals, signs of intoxication were observed, and the clinical picture was recorded. Pathological anatomical autopsy of the dead mice was performed as they died. Surviving mice were autopsied 14 days after the start of the experiment, immediately after their euthanasia. Results. The average lethal doses of the GIZh-298 substance when administered orally to mice were determined: LD50 in females was 356 mg/kg, LD50 in males was 438 mg/kg. Conclusion. Compound GIZH-298 for oral administration according to the classification of Sidorov K.K. (1973) is a moderately toxic substance and can be assigned to the 3rd class of toxicity, and in accordance with GOST 12.1.007-76 β to the 3rd hazard class.ΠΠΊΡΡΠ°Π»ΡΠ½ΠΎΡΡΡ. ΠΡΠ΅Π½ΠΊΠ° ΠΎΡΡΡΠΎΠΉ ΡΠΎΠΊΡΠΈΡΠ½ΠΎΡΡΠΈ β ΠΎΠ±ΡΠ·Π°ΡΠ΅Π»ΡΠ½ΡΠΉ ΡΡΠ°ΠΏ Π΄ΠΎΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ Π±Π΅Π·ΠΎΠΏΠ°ΡΠ½ΠΎΡΡΠΈ Π»Π΅ΠΊΠ°ΡΡΡΠ²Π΅Π½Π½ΡΡ
ΡΡΠ΅Π΄ΡΡΠ² ΠΈ ΡΠ°ΡΠΌΠ°ΡΠ΅Π²ΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΡΠ±ΡΡΠ°Π½ΡΠΈΠΉ. Π¦Π΅Π»ΡΡ Π½Π°ΡΡΠΎΡΡΠ΅Π³ΠΎ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ Π±ΡΠ»ΠΎ ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΠ΅ ΠΏΠ°ΡΠ°ΠΌΠ΅ΡΡΠΎΠ² ΠΎΡΡΡΠΎΠΉ ΡΠΎΠΊΡΠΈΡΠ½ΠΎΡΡΠΈ ΡΡΠ±ΡΡΠ°Π½ΡΠΈΠΈ ΠΠΠ-298. ΠΠ΅ΡΠΎΠ΄Ρ. ΠΠΠ-298 Π²Π²ΠΎΠ΄ΠΈΠ»ΠΈ ΠΎΠ΄Π½ΠΎΠΊΡΠ°ΡΠ½ΠΎ ΠΏΠ΅ΡΠΎΡΠ°Π»ΡΠ½ΠΎ Π°ΡΡΠ±ΡΠ΅Π΄Π½ΡΠΌ ΠΌΡΡΠ°ΠΌ ΠΎΠ±ΠΎΠ΅Π³ΠΎ ΠΏΠΎΠ»Π° Π² Π΄ΠΎΠ·Π°Ρ
350β550 ΠΌΠ³/ΠΊΠ³. ΠΠΎΠ½ΡΡΠΎΠ»ΡΠ½ΡΠ΅ ΠΌΡΡΠΈ ΠΏΠΎΠ»ΡΡΠ°Π»ΠΈ Π² ΡΠ΅Ρ
ΠΆΠ΅ ΡΡΠ»ΠΎΠ²ΠΈΡΡ
0,5 ΠΌΠ» 1 % ΡΠ°ΡΡΠ²ΠΎΡΠ° ΠΊΡΠ°Ρ
ΠΌΠ°Π»Π°. Π Ρ
ΠΎΠ΄Π΅ ΡΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ° Π½Π°Π±Π»ΡΠ΄Π°Π»ΠΈ Π·Π° Π³ΠΈΠ±Π΅Π»ΡΡ ΠΆΠΈΠ²ΠΎΡΠ½ΡΡ
, ΠΏΡΠΈΠ·Π½Π°ΠΊΠ°ΠΌΠΈ ΠΈΠ½ΡΠΎΠΊΡΠΈΠΊΠ°ΡΠΈΠΈ, ΡΠ΅Π³ΠΈΡΡΡΠΈΡΠΎΠ²Π°Π»ΠΈ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΡΡ ΠΊΠ°ΡΡΠΈΠ½Ρ. ΠΠ°ΡΠΎΠ»ΠΎΠ³ΠΎΠ°Π½Π°ΡΠΎΠΌΠΈΡΠ΅ΡΠΊΠΎΠ΅ Π²ΡΠΊΡΡΡΠΈΠ΅ ΠΏΠ°Π²ΡΠΈΡ
ΠΌΡΡΠ΅ΠΉ ΠΏΡΠΎΠ²ΠΎΠ΄ΠΈΠ»ΠΈ ΠΏΠΎ ΠΌΠ΅ΡΠ΅ ΠΈΡ
Π³ΠΈΠ±Π΅Π»ΠΈ. ΠΡΠΆΠΈΠ²ΡΠΈΡ
ΠΌΡΡΠ΅ΠΉ Π²ΡΠΊΡΡΠ²Π°Π»ΠΈ ΡΠΏΡΡΡΡ 14 ΡΡΡΠΎΠΊ ΠΎΡ Π½Π°ΡΠ°Π»Π° ΡΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ°, ΡΡΠ°Π·Ρ ΠΏΠΎΡΠ»Π΅ ΠΈΡ
ΡΠ²ΡΠ°Π½Π°Π·ΠΈΠΈ. Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ. ΠΠΏΡΠ΅Π΄Π΅Π»Π΅Π½Ρ ΡΡΠ΅Π΄Π½Π΅ΡΠΌΠ΅ΡΡΠ΅Π»ΡΠ½ΡΠ΅ Π΄ΠΎΠ·Ρ ΡΡΠ±ΡΡΠ°Π½ΡΠΈΠΈ ΠΠΠ-298 ΠΏΡΠΈ ΠΏΠ΅ΡΠΎΡΠ°Π»ΡΠ½ΠΎΠΌ Π²Π²Π΅Π΄Π΅Π½ΠΈΠΈ ΠΌΡΡΠ°ΠΌ: LD50 Ρ ΡΠ°ΠΌΠΎΠΊ ΡΠΎΡΡΠ°Π²ΠΈΠ»Π° 356 ΠΌΠ³/ΠΊΠ³, LD50 Ρ ΡΠ°ΠΌΡΠΎΠ² β 438 ΠΌΠ³/ΠΊΠ³. ΠΠ°ΠΊΠ»ΡΡΠ΅Π½ΠΈΠ΅. Π‘ΠΎΠ΅Π΄ΠΈΠ½Π΅Π½ΠΈΠ΅ ΠΠΠ-298 ΠΏΡΠΈ ΠΏΠ΅ΡΠΎΡΠ°Π»ΡΠ½ΠΎΠΌ Π²Π²Π΅Π΄Π΅Π½ΠΈΠΈ ΠΏΠΎ ΠΊΠ»Π°ΡΡΠΈΡΠΈΠΊΠ°ΡΠΈΠΈ Π‘ΠΈΠ΄ΠΎΡΠΎΠ²Π° Π.Π. (1973 Π³.) ΡΠ²Π»ΡΠ΅ΡΡΡ ΡΠΌΠ΅ΡΠ΅Π½Π½ΠΎ ΡΠΎΠΊΡΠΈΡΠ½ΡΠΌ Π²Π΅ΡΠ΅ΡΡΠ²ΠΎΠΌ ΠΈ ΠΌΠΎΠΆΠ΅Ρ Π±ΡΡΡ ΠΎΡΠ½Π΅ΡΠ΅Π½ΠΎ ΠΊ 3 ΠΊΠ»Π°ΡΡΡ ΡΠΎΠΊΡΠΈΡΠ½ΠΎΡΡΠΈ, Π° Π² ΡΠΎΠΎΡΠ²Π΅ΡΡΡΠ²ΠΈΠΈ Ρ ΠΠΠ‘Π’ΠΎΠΌ 12.1.007-76 β ΠΊ 3 ΠΊΠ»Π°ΡΡΡ ΠΎΠΏΠ°ΡΠ½ΠΎΡΡΠΈ