Mechanical testing of polyurethane foams to cover lower limb prostheses

Despite the aesthetic and functional importance of foam cosmeses, the foam mechanical behaviour has not been quantified in the literature. This paper reports the results of testing two commonly used foams to determine their material properties. The works aims to enable the FEA modelling of cosmeses

On the quasi-steady state assumption applied to Michaelis-Menten and suicide substrate reactions with diffusion

We consider a recent extension to the validity of the quasi-steady-state assumption (QSSA) which includes the case where the ratio of the initial enzyme to substrate concentration is not necessarily small. We extend the analysis to include diffusion of substrate, in which case the initial enzyme to substrate ratio is spatially dependent and no longer constant. We show that the region in which the QSSA holds depends on the nature of the enzyme-substrate reaction: if the enzyme is inactivated by the substrate then the QSSA holds in a growing disc; if the enzyme is unchanged after reaction then the QSSA holds in a ring travelling through space

A computer vision approach to classification of birds in flight from video sequences

Bird populations are an important bio-indicator; so collecting reliable data is useful for ecologists helping conserve and manage fragile ecosystems. However, existing manual monitoring methods are labour-intensive, time-consuming, and error-prone. The aim of our work is to develop a reliable system, capable of automatically classifying individual bird species in flight from videos. This is challenging, but appropriate for use in the field, since there is often a requirement to identify in flight, rather than when stationary. We present our work in progress, which uses combined appearance and motion features to classify and present experimental results across seven species using Normal Bayes classifier with majority voting and achieving a classification rate of 86%

Suicide substrate reaction-diffusion equations: varying the source

The suicide substrate reaction is a model for certain enzyme-inhibiting drugs. This reaction system is examined assuming that the substrate diffuses freely while the enzyme remains fixed. Two sets of initial and boundary conditions are examined: one modelling an instantaneous point source, akin to an injection of substrate, the other, a continuous point source, akin to a continuing influx, or intravenous drip, of substrate. The quasi-steady-state assumption is applied to obtain analytical solutions for a limited parameter space. Finally, further applications of numerical and analytical experimentation on pharmaceutical mechanisms are described

Symetric Monopoles

We discuss $SU(2)$ Bogomolny monopoles of arbitrary charge $k$ invariant under various symmetry groups. The analysis is largely in terms of the spectral curves, the rational maps, and the Nahm equations associated with monopoles. We consider monopoles invariant under inversion in a plane, monopoles with cyclic symmetry, and monopoles having the symmetry of a regular solid. We introduce the notion of a strongly centred monopole and show that the space of such monopoles is a geodesic submanifold of the monopole moduli space. By solving Nahm's equations we prove the existence of a tetrahedrally symmetric monopole of charge $3$ and an octahedrally symmetric monopole of charge $4$, and determine their spectral curves. Using the geodesic approximation to analyse the scattering of monopoles with cyclic symmetry, we discover a novel type of non-planar $k$-monopole scattering process

Modelling delta-notch perturbations during zebrafish somitogenesis

The discovery over the last 15 years of molecular clocks and gradients in the pre-somitic mesoderm of numerous vertebrate species has added significant weight to Cooke and Zeeman's ‘clock and wavefront’ model of somitogenesis, in which a travelling wavefront determines the spatial position of somite formation and the somitogenesis clock controls periodicity (Cooke and Zeeman, 1976). However, recent high-throughput measurements of spatiotemporal patterns of gene expression in different zebrafish mutant backgrounds allow further quantitative evaluation of the clock and wavefront hypothesis. In this study we describe how our recently proposed model, in which oscillator coupling drives the propagation of an emergent wavefront, can be used to provide mechanistic and testable explanations for the following observed phenomena in zebrafish embryos: (a) the variation in somite measurements across a number of zebrafish mutants; (b) the delayed formation of somites and the formation of ‘salt and pepper’ patterns of gene expression upon disruption of oscillator coupling; and (c) spatial correlations in the ‘salt and pepper’ patterns in Delta-Notch mutants. In light of our results, we propose a number of plausible experiments that could be used to further test the model

Sequential pattern formation in a model for skin morphogenesis

During morphogenesis regular patterns often develop behind a frontier of pattern formation which travels across the prospective tissue. Here the authors consider the propagating patterns exhibited in a two-dimensional domain by a tissue interaction mechanochemical model for skin pattern formation. It is shown that the model can exhibit travelling waves of complex spatial pattern formation. Two alternative mechanisms that can produce such sequential patterning are presented. In particular, it is demonstrated that the specification of a simple quasi-one-dimensional pattern is all that is required to determine a complex two-dimensional pattern. Finally, the model solutions are related to actual pattern propagation during chick feather primordia initiation