6,573 research outputs found
Design and Implementation of a Measurement-Based Policy-Driven Resource Management Framework For Converged Networks
This paper presents the design and implementation of a measurement-based QoS
and resource management framework, CNQF (Converged Networks QoS Management
Framework). CNQF is designed to provide unified, scalable QoS control and
resource management through the use of a policy-based network management
paradigm. It achieves this via distributed functional entities that are
deployed to co-ordinate the resources of the transport network through
centralized policy-driven decisions supported by measurement-based control
architecture. We present the CNQF architecture, implementation of the prototype
and validation of various inbuilt QoS control mechanisms using real traffic
flows on a Linux-based experimental test bed.Comment: in Ictact Journal On Communication Technology: Special Issue On Next
Generation Wireless Networks And Applications, June 2011, Volume 2, Issue 2,
Issn: 2229-6948(Online
Positive allosteric modulators of the a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor
L-glutamate is the major excitatory neurotransmitter in the mammalian central nervous system (CNS) and plays a fundamental role in the control of motor function, cognition and mood. The physiological effects of glutamate are mediated through two functionally distinct receptor families. While activation of metabotropic (G-protein coupled) glutamate receptors results in modulation of neuronal excitability and transmission, the ionotropic glutamate receptors (ligand-gated ion channels) are responsible for mediating the fast synaptic response to extracellular glutamate
Population response of triploid grass carp to declining levels of hydrilla in the Santee Cooper Reservoirs, South Carolina
Approximately 768,500 triploid grass carp (
Ctenopharyngodon
idella
Valenciennes) were stocked into the Santee Cooper
reservoirs, South Carolina between 1989 and 1996 to
control hydrilla (
Hydrilla verticillata
(L.f.) Royle). Hydrilla
coverage was reduced from a high of 17,272 ha during 1994
to a few ha by 1998. During 1997, 1998 and 1999, at least 98
triploid grass carp were collected yearly for population monitoring.
Estimates of age, growth, and mortality, as well as
population models, were used in the study to monitor triploid
grass carp and predict population trends. Condition declined
from that measured during a previous study in 1994.
The annual mortality rate was estimated at 28% in 1997, 32%
in 1998 and 39% in 1999; however, only the 1999 mortality
rate was significantly different. Few (2 out of 98) of the triploid
grass carp collected during 1999 were older than age 9.
We expect increased mortality due to an aging population
and sparse hydrilla coverage. During 1999, we estimated about
63,000 triploid grass carp system wide and project less than
3,000 fish by 2004, assuming no future stocking.
management, population size
Ctenopharyngodon idella, Hydrill
Young children's cognitive achievement: home learning environment, language and ethnic background
For decades, research has shown differences in cognitive assessment scores between White and minority ethnic group(s) learners as well as differences across different minority ethnic groups. More recent data have indicated that the home learning environment and languages spoken can impact cognitive assessment and other corollary outcomes. This study uses the Millennium Cohort Study to jointly assess how minority ethnic group, home learning environment and home languages predict child cognitive assessment scores. Regression analyses were conducted using two assessment measures. The following is hypothesised: (1) cognitive achievement scores vary by minority ethnic group, (2) more home learning environment in early childhood leads to higher cognitive development scores and (3) English only in the home yields the highest cognitive scores while no English in the home yields the lowest. Findings reveal that there are differences in cognitive scores along ethnic group categories although there are also some unexpected findings. Home learning environment does not play as large a role as was predicted in raising the assessment scores overall for learners while speaking English in the home does, irrespective of ethnic background
Synthetic DNA immunotherapy in biochemically relapsed prostate cancer
Background: INO-5150 (PSA and PSMA) +/- INO-9012 (IL-12), a synthetic DNA immunotherapy, was assessed for safety, immunogenicity and efficacy in biochemically recurrent prostate cancer patients (pts).
Methods: Phase I, open-label, multi-center study in the US included pts with rising PSA after surgery and/or RT, PSA doubling time (PSADT) \u3e3 months (mos), testosterone \u3e150 ng/dL and no concurrent ADT. Safety, immunogenicity and efficacy (PSA kinetics, PFS) were evaluated in 4 treatment arms of 15 pts each. Arms A: 2mg INO-5150, B: 8.5 mg INO-5150, C: 2mg INO-5150 + 1mg INO-9012 and D: 8.5mg INO-5150 + 1mg INO-9012. Pts received 4 IM doses of vaccine followed by electroporation on day 0, wks 3, 12 and 24 and were followed for 72 wks.
Results: 50/61 (82%) pts completed all visits and treatments were well tolerated with no safety concerns. Median PFS for overall population [N = 61, baseline (D0) PSADT range (mos) 1.5-217.1, median 9.8] and for a subset of pts with D0 PSADT ≤12mos (N = 36) has not yet been reached (FU 3-19 mos). 86% of pts with D0 PSADT ≤12 mos were progression free through 19mos FU. 27 out of 36 (75%) pts with D0 PSADT≤ 12 mos had disease stabilization at wks 27 evidenced by significant improvement in log2PSA change over time (slope) and PSADT from D0 (Slope=0.19 declined to 0.1, PSADT=5.3 improved to 10.1 mos, p = \u3c0.0001). This effect was maintained at wk 72 (Slope=0.09, PSADT=10.6, p = \u3c0.0001). Immunogenicity was observed in 77% (47/61) of pts by multiple immunologic assessments. Patient immunogenicity to INO-5150 as determined by CD38 and Perforin + CD8 T cell immune reactivity correlated with attenuated % PSA rise compared to pts without reactivity (p = 0.05, n = 50).
Conclusions: INO-5150 +/- INO-9012 was safe, well tolerated and immunogenic. Clinical efficacy was observed in the patients with D0 PSADT≤ 12 mos as evidenced by a significant dampening of log2PSA change over time and increased PSADT up to 72 weeks FU. Additional genomic analyses are ongoing to further elucidate the correlation of immunologic efficacy and clinical benefit. (NCT02514213)
Risky behaviors performed by the piglet 72 hours after parturition that can contribute to pre-weaning mortality when housed in farrowing huts
The objective was to compare the behavior of loose-housed outdoor litters that had one or more piglet mortalities (CR; n=4) compared to litters where no mortalities occurred (NC; n=4). The litter of piglets was observed using 10-min scan samples over 72 h from birth and individual piglets were continually observed 1 h prior to death. Postures, nursing, unknown, location within the hut, and vicinity to the sow were determined. There were no differences observed for any measures 1 h before a piglet\u27s death. There were no differences for treatment or day by treatment over the 72 h for behaviors or vicinity to sow. There was a day effect with piglets becoming more inactive and nursing less often from d1 to d3. There was a day effect for vicinity to sow with piglets spending less time by the sow over the 3 d. Few behavioral differences were observed between treatments
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