A Review of Frailty Syndrome and Its Physical, Cognitive and Emotional Domains in the Elderly

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A 3D Model of the 4GLS VUV-FEL Conceptual Design Including Improved Modelling of the Optical Cavity

The Conceptual Design Report for the 4th Generation Light Source (4GLS) at Daresbury Laboratory in the UK was published in Spring 2006. The proposal includes a low-Q cavity (also called a regenerative amplifier) FEL to generate variably-polarised, temporally-coherent radiation in the photon energy range 3-10eV. A new simulation code has been developed that incorporates the 3D FEL code Genesis 1.3 and which simulates in 3D the optical components and radiation propagation within the non-amplifying sections of an optical cavity*. This code is used to estimate the optimum low-Q cavity design and characterise the output from the 4GLS VUV-FEL

Short-Interval Cortical Inhibition and Intracortical Facilitation during Submaximal Voluntary Contractions Changes with Fatigue

This study determined whether short-interval intracortical inhibition (SICI) and intracortical facilitation (ICF) change during a sustained submaximal isometric contraction. On 2 days, 12 participants (6 men, 6 women) performed brief (7-s) elbow flexor contractions before and after a 10-min fatiguing contraction; all contractions were performed at the level of integrated electromyographic activity (EMG) which produced 25 % maximal unfatigued torque. During the brief 7-s and 10-min submaximal contractions, single (test) and paired (conditioning–test) transcranial magnetic stimuli were applied over the motor cortex (5 s apart) to elicit motor-evoked potentials (MEPs) in biceps brachii. SICI and ICF were elicited on separate days, with a conditioning–test interstimulus interval of 2.5 and 15 ms, respectively. On both days, integrated EMG remained constant while torque fell during the sustained contraction by ~51.5 % from control contractions, perceived effort increased threefold, and MVC declined by 21–22 %. For SICI, the conditioned MEP during control contractions (74.1 ± 2.5 % of unconditioned MEP) increased (less inhibition) during the sustained contraction (last 2.5 min: 86.0 ± 5.1 %; P \u3c 0.05). It remained elevated in recovery contractions at 2 min (82.0 ± 3.8 %; P \u3c 0.05) and returned toward control at 7-min recovery (76.3 ± 3.2 %). ICF during control contractions (conditioned MEP 129.7 ± 4.8 % of unconditioned MEP) decreased (less facilitation) during the sustained contraction (last 2.5 min: 107.6 ± 6.8 %; P \u3c 0.05) and recovered to 122.8 ± 4.3 % during contractions after 2 min of recovery. Both intracortical inhibitory and facilitatory circuits become less excitable with fatigue when assessed during voluntary activity, but their different time courses of recovery suggest different mechanisms for the fatigue-related changes of SICI and ICF

Transform-limited X-ray pulse generation from a high-brightness self-amplified spontaneous-emission free-electron laser

A method to achieve high-brightness self-amplified spontaneous emission (HB-SASE) in the free-electron laser (FEL) is described. The method uses repeated nonequal electron beam delays to delocalize the collective FEL interaction and break the radiation coherence length dependence on the FEL cooperation length. The method requires no external seeding or photon optics and so is applicable at any wavelength or repetition rate. It is demonstrated, using linear theory and numerical simulations, that the radiation coherence length can be increased by approximately 2 orders of magnitude over SASE with a corresponding increase in spectral brightness. Examples are shown of HB-SASE generating transform-limited FEL pulses in the soft x-ray and near transform-limited pulses in the hard x-ray. Such pulses may greatly benefit existing applications and may also open up new areas of scientific research

Physical phenomena in containerless glass processing

Experiments were conducted on bubble migration in rotating liquid bodies contained in a sphere. Experiments were initiated on the migration of a drop in a slightly less dense continuous phase contained in a rotating sphere. A refined apparatus for the study of thermocapillar flow in a glass melt was built, and data were acquired on surface velocities in the melt. Similar data also were obtained from an ambient temperature fluid model. The data were analyzed and correlated with the aid of theory. Data were obtained on flow velocities in a pendant drop heated from above. The motion in this system was driven principally by thermocapillarity. An apparatus was designed for the study of volatilization from a glass melt

Exploring Zeptosecond Quantum Equilibration Dynamics: From Deep-Inelastic to Fusion-Fission Outcomes in 58^{58}Ni+60^{60}Ni Reactions

Energy dissipative processes play a key role in how quantum many-body systems dynamically evolve towards equilibrium. In closed quantum systems, such processes are attributed to the transfer of energy from collective motion to single-particle degrees of freedom; however, the quantum many-body dynamics of this evolutionary process are poorly understood. To explore energy dissipative phenomena and equilibration dynamics in one such system, an experimental investigation of deep-inelastic and fusion-fission outcomes in the $^{58}$Ni+$^{60}$Ni reaction has been carried out. Experimental outcomes have been compared to theoretical predictions using Time Dependent Hartree Fock and Time Dependent Random Phase Approximation approaches, which respectively incorporate one-body energy dissipation and fluctuations. Excellent quantitative agreement has been found between experiment and calculations, indicating that microscopic models incorporating one-body dissipation and fluctuations provide a potential tool for exploring dissipation in low-energy heavy ion collisions.Comment: 11 pages, 9 figures, 1 table, including Supplemental Material - Version accepted for publication in Physical Review Letter

Energy-saving compression valve of the rock drill

The relevance of the research is due to the necessity to create pneumatic rock drills with low air consumption. The article analyzes the reasons for low efficiency of percussive machines. The authors state that applying a single distribution body in the percussive mechanism does not allow carrying out a low-energy operating cycle of the mechanism. Using the studied device as an example, it is substantiated that applying a compression valve with two distribution bodies separately operating the working chambers makes it possible to significantly reduce the airflow. The authors describe the construction of a core drill percussive mechanism and the operation of a compression valve. It is shown that in the new percussive mechanism working chambers are cut off the circuit by the time when exhaust windows are opened by the piston and air is not supplied into the cylinder up to 20% of the cycle time. The air flow rate of the new mechanism was 3.8 m3/min. In comparison with the drill PK-75, the overall noise level of the new machine is lower by 8-10 dB, while the percussive mechanism efficiency is 2.3 times higher

The association between polypharmacy and late life deficits in cognitive, physical and emotional capability : a cohort study

Open via Springer Compact Agreement Acknowledgements We thank the participants of the Aberdeen Birth Cohort of 1936. Funding ABC1936 was funded (1999–2009) by Biotechnology and Biological Sciences Research Council, Scottish Health Department, Wellcome Trust, Medical Research Council, Alzheimer Research UK, Alzheimer Society and University of Aberdeen Development Trust. This work was supported by the Roland Sutton Academic Trust, Morningfield Association and the Rabin Ezra Scholarship Trust, which provides salary cost and consumables to MK.Peer reviewedPublisher PD