5,983 research outputs found
The UV Continuum of Quasars: Models and SDSS Spectral Slopes
We measure long (2200-4000 ang) and short (1450-2200 ang) wavelength spectral
slopes \alpha (F_\nu proportional to \nu^\alpha) for quasar spectra from the
Sloan Digital Sky Survey. The long and short wavelength slopes are computed
from 3646 and 2706 quasars with redshifts in the z=0.76-1.26 and z=1.67-2.07
ranges, respectively. We calculate mean slopes after binning the data by
monochromatic luminosity at 2200 ang and virial mass estimates based on
measurements of the MgII line width and 3000 ang continuum luminosity. We find
little evidence for mass dependent variations in the mean slopes, but a
significant luminosity dependent trend in the near UV spectral slopes is
observed with larger (bluer) slopes at higher luminosities. The far UV slopes
show no clear variation with luminosity and are generally lower (redder) than
the near UV slopes at comparable luminosities, suggesting a slightly concave
quasar continuum shape. We compare these results with Monte Carlo distributions
of slopes computed from models of thin accretion disks, accounting for
uncertainties in the mass estimates. The model slopes produce mass dependent
trends which are larger than observed, though this conclusion is sensitive to
the assumed uncertainties in the mass estimates. The model slopes are also
generally bluer than observed, and we argue that reddening by dust intrinsic to
the source or host galaxy may account for much of the discrepancy.Comment: To be published in ApJ, 18 pages, 10 figure
Interplay between carrier and impurity concentrations in annealed GaMnAs intrinsic anomalous Hall Effect
Investigating the scaling behavior of annealed GaMnAs anomalous
Hall coefficients, we note a universal crossover regime where the scaling
behavior changes from quadratic to linear, attributed to the anomalous Hall
Effect intrinsic and extrinsic origins, respectively. Furthermore, measured
anomalous Hall conductivities when properly scaled by carrier concentration
remain constant, equal to theoretically predicated values, spanning nearly a
decade in conductivity as well as over 100 K in T. Both the qualitative
and quantitative agreement confirms the validity of new equations of motion
including the Berry phase contributions as well as tunablility of the intrinsic
anomalous Hall Effect.Comment: 4 pages, 5 figure
The cap-snatching SFTSV endonuclease domain is an antiviral target
Severe fever with thrombocytopenia syndrome virus (SFTSV) is a tick-borne virus with 12%-30% case mortality rates and is related to the Heartland virus (HRTV) identified in the United States. Together, SFTSV and HRTV are emerging segmented, negative-sense RNA viral (sNSV) pathogens with potential global health impact. Here, we characterize the amino-terminal cap-snatching endonuclease domain of SFTSV polymerase (L) and solve a 2.4-Å X-ray crystal structure. While the overall structure is similar to those of other cap-snatching sNSV endonucleases, differences near the C terminus of the SFTSV endonuclease suggest divergence in regulation. Influenza virus endonuclease inhibitors, including the US Food and Drug Administration (FDA) approved Baloxavir (BXA), inhibit the endonuclease activity in in vitro enzymatic assays and in cell-based studies. BXA displays potent activity with a half maximal inhibitory concentration (I
Evidence of metallic clustering in annealed Ga1-xMnxAs from atypical scaling behavior of the anomalous Hall coefficient
We report on the anomalous Hall coefficient and longitudinal resistivity
scaling relationships on a series of annealed Ga1-xMnxAs epilayers (x~0.055).
As-grown samples exhibit scaling parameter n of ~ 1. Near the optimal annealing
temperature, we find n ~ 2 to be consistent with recent theories on the
intrinsic origins of anomalous Hall Effect in Ga1-xMnxAs. For annealing
temperatures far above the optimum, we note n > 3, similar behavior to certain
inhomogeneous systems. This observation of atypical behavior agrees well with
characteristic features attributable to spherical resonance from metallic
inclusions from optical spectroscopy measurements.Comment: 3 pages, 3 figure
TRPV1-expressing primary afferents generate behavioral responses to pruritogens via multiple mechanisms
The mechanisms that generate itch are poorly understood at both the molecular and cellular levels despite its clinical importance. To explore the peripheral neuronal mechanisms underlying itch, we assessed the behavioral responses (scratching) produced by s.c. injection of various pruritogens in PLCβ3- or TRPV1-deficient mice. We provide evidence that at least 3 different molecular pathways contribute to the transduction of itch responses to different pruritogens: 1) histamine requires the function of both PLCβ3 and the TRPV1 channel; 2) serotonin, or a selective agonist, α-methyl-serotonin (α-Me-5-HT), requires the presence of PLCβ3 but not TRPV1, and 3) endothelin-1 (ET-1) does not require either PLCβ3 or TRPV1. To determine whether the activity of these molecules is represented in a particular subpopulation of sensory neurons, we examined the behavioral consequences of selectively eliminating 2 nonoverlapping subsets of nociceptors. The genetic ablation of MrgprD^+ neurons that represent ≈90% of cutaneous nonpeptidergic neurons did not affect the scratching responses to a number of pruritogens. In contrast, chemical ablation of the central branch of TRPV1+ nociceptors led to a significant behavioral deficit for pruritogens, including α-Me-5-HT and ET-1, that is, the TRPV1-expressing nociceptor was required, whether or not TRPV1 itself was essential. Thus, TRPV1 neurons are equipped with multiple signaling mechanisms that respond to different pruritogens. Some of these require TRPV1 function; others use alternate signal transduction pathways
Supergravity Instabilities of Non-Supersymmetric Quantum Critical Points
Motivated by the recent use of certain consistent truncations of M-theory to
study condensed matter physics using holographic techniques, we study the
SU(3)-invariant sector of four-dimensional, N=8 gauged supergravity and compute
the complete scalar spectrum at each of the five non-trivial critical points.
We demonstrate that the smaller SU(4)^- sector is equivalent to a consistent
truncation studied recently by various authors and find that the critical point
in this sector, which has been proposed as the ground state of a holographic
superconductor, is unstable due to a family of scalars that violate the
Breitenlohner-Freedman bound. We also derive the origin of this instability in
eleven dimensions and comment on the generalization to other embeddings of this
critical point which involve arbitrary Sasaki-Einstein seven manifolds. In the
spirit of a resurging interest in consistent truncations, we present a formal
treatment of the SU(3)-invariant sector as a U(1)xU(1) gauged N=2 supergravity
theory coupled to one hypermultiplet.Comment: 46 page
Correlational Origin of the Roton Minimum
We present compelling evidence supporting the conjecture that the origin of
the roton in Bose-condensed systems arises from strong correlations between the
constituent particles. By studying the two dimensional bosonic dipole systems a
paradigm, we find that classical molecular dynamics (MD) simulations provide a
faithful representation of the dispersion relation for a low- temperature
quantum system. The MD simulations allow one to examine the effect of coupling
strength on the formation of the roton minimum and to demonstrate that it is
always generated at a sufficiently high enough coupling. Moreover, the
classical images of the roton-roton, roton-maxon, etc. states also appear in
the MD simulation spectra as a consequence of the strong coupling.Comment: 7 pages, 4 figure
Carbon reductions and health co-benefits from US residential energy efficiency measures
The United States (US) Clean Power Plan established state-specific carbon dioxide (CO2) emissions reduction goals for fossil fuel-fired electricity generating units (EGUs). States may achieve these goals through multiple mechanisms, including measures that can achieve equivalent CO2 reductions such as residential energy efficiency, which will have important co-benefits. Here, we develop state-resolution simulations of the economic, health, and climate benefits of increased residential insulation, considering EGUs and residential combustion. Increasing insulation to International Energy Conservation Code 2012 levels for all single-family homes in the US in 2013 would lead to annual reductions of 80 million tons of CO2 from EGUs, with annual co-benefits including 30 million tons of CO2 from residential combustion and 320 premature deaths associated with criteria pollutant emissions from both EGUs and residential combustion sources. Monetized climate and health co-benefits average 12–$390). State-specific co-benefit estimates can inform development of optimal Clean Power Plan implementation strategies
Efficiency of Energy Transduction in a Molecular Chemical Engine
A simple model of the two-state ratchet type is proposed for molecular
chemical engines that convert chemical free energy into mechanical work and
vice versa. The engine works by catalyzing a chemical reaction and turning a
rotor. Analytical expressions are obtained for the dependences of rotation and
reaction rates on the concentrations of reactant and product molecules, from
which the performance of the engine is analyzed. In particular, the efficiency
of energy transduction is discussed in some detail.Comment: 4 pages, 4 fugures; title modified, figures 2 and 3 modified, content
changed (pages 1 and 4, mainly), references adde
Mixed Bino-Wino-Higgsino Dark Matter in Gauge Messenger Models
Almost degenerate bino and wino masses at the weak scale is one of unique
features of gauge messenger models. The lightest neutralino is a mixture of
bino, wino and higgsino and can produce the correct amount of the dark matter
density if it is the lightest supersymmetric particle. Furthermore, as a result
of squeezed spectrum of superpartners which is typical for gauge messenger
models, various co-annihilation and resonance regions overlap and very often
the correct amount of the neutralino relic density is generated as an interplay
of several processes. This feature makes the explanation of the observed amount
of the dark matter density much less sensitive to fundamental parameters. We
calculate the neutralino relic density assuming thermal history and present
both spin independent and spin dependent cross sections for the direct
detection. We also discuss phenomenological constraints from b to s gamma and
muon g-2 and compare results of gauge messenger models to well known results of
the mSUGRA scenario.Comment: 27 pages, 9 figures, references added, version to appear at JCA
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