70 research outputs found
Insecurity of Quantum Secure Computations
It had been widely claimed that quantum mechanics can protect private
information during public decision in for example the so-called two-party
secure computation. If this were the case, quantum smart-cards could prevent
fake teller machines from learning the PIN (Personal Identification Number)
from the customers' input. Although such optimism has been challenged by the
recent surprising discovery of the insecurity of the so-called quantum bit
commitment, the security of quantum two-party computation itself remains
unaddressed. Here I answer this question directly by showing that all
``one-sided'' two-party computations (which allow only one of the two parties
to learn the result) are necessarily insecure. As corollaries to my results,
quantum one-way oblivious password identification and the so-called quantum
one-out-of-two oblivious transfer are impossible. I also construct a class of
functions that cannot be computed securely in any ``two-sided'' two-party
computation. Nevertheless, quantum cryptography remains useful in key
distribution and can still provide partial security in ``quantum money''
proposed by Wiesner.Comment: The discussion on the insecurity of even non-ideal protocols has been
greatly extended. Other technical points are also clarified. Version accepted
for publication in Phys. Rev.
Atosiban versus betamimetics in the treatment of preterm labour in Germany: an economic evaluation
Targeting Angiogenesis-Dependent Calcified Neoplasms Using Combined Polymer Therapeutics
There is an immense clinical need for novel therapeutics for the treatment of angiogenesis-dependent calcified neoplasms such as osteosarcomas and bone metastases. We developed a new therapeutic strategy to target bone metastases and calcified neoplasms using combined polymer-bound angiogenesis inhibitors. Using an advanced "living polymerization" technique, the reversible addition-fragmentation chain transfer (RAFT), we conjugated the aminobisphosphonate alendronate (ALN), and the potent anti-angiogenic agent TNP-470 with N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer through a Glycine-Glycine-Proline-Norleucine linker, cleaved by cathepsin K, a cysteine protease overexpressed at resorption sites in bone tissues. In this approach, dual targeting is achieved. Passive accumulation is possible due to the increase in molecular weight following polymer conjugation of the drugs, thus extravasating from the tumor leaky vessels and not from normal healthy vessels. Active targeting to the calcified tissues is achieved by ALN's affinity to bone mineral.The anti-angiogenic and antitumor potency of HPMA copolymer-ALN-TNP-470 conjugate was evaluated both in vitro and in vivo. We show that free and conjugated ALN-TNP-470 have synergistic anti-angiogenic and antitumor activity by inhibiting proliferation, migration and capillary-like tube formation of endothelial and human osteosarcoma cells in vitro. Evaluation of anti-angiogenic, antitumor activity and body distribution of HPMA copolymer-ALN-TNP-470 conjugate was performed on severe combined immunodeficiency (SCID) male mice inoculated with mCherry-labeled MG-63-Ras human osteosarcoma and by modified Miles permeability assay. Our targeted bi-specific conjugate reduced VEGF-induced vascular hyperpermeability by 92% and remarkably inhibited osteosarcoma growth in mice by 96%.This is the first report to describe a new concept of a narrowly-dispersed combined polymer therapeutic designed to target both tumor and endothelial compartments of bone metastases and calcified neoplasms at a single administration. This new approach of co-delivery of two synergistic drugs may have clinical utility as a potential therapy for angiogenesis-dependent cancers such as osteosarcoma and bone metastases
Doxorubicin-conjugated PLA-PEG-Folate based polymeric micelle for tumor-targeted delivery: Synthesis and in vitro evaluation
Physico‐Chemical Properties as a Key Factor in Choosing Practically Applicable Biocompatible Polymers
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