The Difference Between Bacterial Growth in Humidifier and Non Humidifier at the Patient Who Got Oxygen Therapy

Introduction: Humidifier is a device for delivering oxygen to the patients. Before using it, the humidifier tube should fill with sterile water. There was a recent study that administering oxygen less than five liter per minutes, the tube was not load with the sterile water. This research aim was to describe the difference between bacterial growth in the humidifier and non humidifier at the patient who got oxygen therapy. Method: The design was the analytic survey with purposive sampling method. The samples were 24 patients. They were divided into two groups. Group one, consisted of 12 patients with humidifier and the others with non humidifier. The instrument was culture equipments diagnostic test and observation guidance. The hypothesis was there was no difference bacterial growth existence in humidifier and non humidifier at the patient who got oxygen therapy. Result: The results showed that there was no significance difference of bacterial growth at time of zero hour (p=0.131). Meanwhile, there was significance different of bacterial growth at time of 12 hour (p=0.046), and time of 24 hour (p=0.046). There was also significance different between bacterial growth in humidifier and non humidifier at the patient who got oxygen therapy (p=0.010). Discussion : The conclusion is a non humidifier device could prevent bacterial and reduce nosocomial infection. It was recommended that hospital should use non humidifier and the humidifier had to disinfect and change the water every 12 hours

Penguatan Peran dan Fungsi Manajemen Kepala Ruang melalui Faktor Kepribadian dan Sosial Organisasi

Implementation of leader nurse in roles and functions management to nurses safety was influenced by several factors.The purpose of this study were to investigate the most associating factors that related to implementation of roles and functions management of head nurse in the application of nursing safety. This study used correlative descriptive research method. The research samplewere 40 people and used total sampling techniques. Personality factors and socialorganizations havea signifi cant association with the implementation ofrolesandfunctions management of head nurseto nursing safety application(p= 0,036andp=0,004). Personalityand socialorganizations needed the attention of hospital managementthrough evaluation ofotherfactorsthat could be increasing the implementation of leader nurse roleand function management to application of nurses safety

HSF2BP Interacts with a Conserved Domain of BRCA2 and Is Required for Mouse Spermatogenesis

The tumor suppressor BRCA2 is essential for homologous recombination (HR), replication fork stability, and DNA interstrand crosslink repair in vertebrates. We identify HSF2BP, a protein previously described as testis specific and not characterized functionally, as an interactor of BRCA2 in mouse embryonic stem cells, where the 2 proteins form a constitutive complex. HSF2BP is transcribed in all cultured human cancer cell lines tested and elevated in some tumor samples. Inactivation of the mouse Hsf2bp gene results in male infertility due to a severe HR defect during spermatogenesis. The BRCA2-HSF2BP interaction is highly evolutionarily conserved and maps to armadillo repeats in HSF2BP and a 68-amino acid region between the BRC repeats and the DNA binding domain of human BRCA2 (Gly2270-Thr2337) encoded by exons 12 and 13. This region of BRCA2 does not harbor known cancer-associated missense mutations and may be involved in the reproductive rather than the tumor-suppressing function of BRCA2. BRCA2 is a key homologous recombination mediator in vertebrates. Brandsma et al. show that it directly interacts with a testis-expressed protein, HSF2BP, and that male mice deficient for HSF2BP are infertile due to a meiotic recombination defect. They also find that HSF2BP contributes to DNA repair in mouse embryonic stem cells