Pumpkin Spice and Two Things Nice

Fall comes every year and I always just let it pass by. With these two cuties here, it’s their first fall, and when it’s a first, there is always time for something special. Spending time carving pumpkins with two babies’ watchful eyes staring my wife and I down, they have curiosity and innocence in their eyes. I couldn’t wait to take this picture to see the joy light up in their eyes as they sat in pumpkins. I couldn’t help but think to myself, there will never be another fall that these sweet babies will be this small again

Care and use of a pressure cooker (1944)

"Reprinted, August, 1944."A pressure cooker is a scientific piece of apparatus and the directions given for its use must be followed explicity if it is to be a safe piece of equipment for home use.Care and use of a pressure cooker. Check the cooker ; Protect the stove top ; Using a pressure cooker for cookin

PROTECTIVE EFFECT OF SYNTHETIC ANTIOXIDANTS AND ETHANOLIC EXTRACT OF BACOPA MONNIERI AGAINST LEAD TOXICITY INDUCED METABOLIC DYSFUNCTIONS IN MICE BRAIN AND LIVER HOMOGENATES: AN IN VITRO APPROACH

Objective: The main objective of the present study was to investigate the ameliorative potential of synthetic antioxidants mixture comprising N-acetyl cysteine, ascorbic acid, tocopheryl acetate, and thiamine as micronutrient combinational therapy and ethanolic extract of Bacopa monnieri as herbal antioxidant therapy approach against lead toxicity-induced metabolic dysfunctions in vitro. Methods: Experimental study involved in vitro exposure of mice brain and liver homogenates to different doses (100 μM, 250 μM, and 500 μM) of lead acetate. The study also involved coadministration of high-dose lead acetate (500 μM) and specific dosage of synthetic antioxidants or ethanolic extract of B. monnieri separately to homogenate cultures. Alterations in metabolic parameters of protein levels and lipid peroxidation were analyzed for evaluating the protective effect of synthetic antioxidants and B. monnieri against lead intoxication. Results: Results revealed dose-dependent statistically significant (p<0.001) reduction in protein levels and elevation in lipid peroxidation in lead acetate exposed mice brain and liver homogenates as compared to their respective control groups. Coadministration of lead acetate and synthetic antioxidants mixture or B. monnieri in the brain and liver homogenates conferred protection and manifested maintenance of studied biochemical parameters nearest to control groups. Ameliorative efficacy of B. monnieri against lead-induced neurotoxicity and hepatotoxicity was found to be more pronounced than that of a mixture of synthetic antioxidants. Conclusion: Synthetic antioxidants mixture (N-acetyl cysteine, ascorbic acid, tocopheryl acetate, and thiamine) and B. monnieri exhibited remarkable therapeutic efficacy against lead toxicity-induced metabolic dysfunctions in mice brain and liver homogenates by virtue of their antioxidant, neuroprotective, and hepatoprotective abilities

AMELIORATIVE ACTION OF SYNTHETIC AND HERBAL ANTIOXIDANTS ON LEAD INDUCED HEPATOTOXICITY: AN IN VITRO STUDY

ABSTRACTObjective: A lead is one of the most hazardous and persistent environmental toxicants of global concern today. The lead has propensity to act as apotent mammalian systemic toxicant. Therefore, investigation of effective ameliorative techniques against lead toxicity through proper exploration ofmolecular mechanisms is the main objective of the current study.Methods: Present in vitro study deals with the investigation of ameliorative effect of specific synthetic antioxidants in a mixture especially,N-acetyl cysteine (5.5 mM/kg/day), ascorbic acid (200 mg/kg/day), tocopheryl acetate (160 mg/kg/day), and thiamine (30 mg/kg/day) as novelcombinational therapy approach as well as Bacopa monnieri (10 mg/kg/day) as herbal antioxidant therapy against lead induced hepatotoxicity.The current synergistic study involves culturing of goat liver in Dulbecco's Modified Eagle Medium:F12 (1:1 mixture) culture media containing1 ppm lead acetate along with co-administration of selective antioxidants at prescribed dosage for 6 hrs. Selective biochemical parameters suchas lipid peroxidation (LPO), protein levels, alkaline phosphatase (ALPase), acid phosphatase (ACPase), succinate dehydrogenase (SDH), adenosinetriphosphatase (ATPase), and superoxide dismutase (SOD) activities were analyzed and observed for protection against lead intoxication.Results: Results indicate significant alterations in all biochemical parameters studied in lead exposed cultures as compared to control. Total andsoluble proteins, ALPase, SDH, and ATPase showed significant reduction while LPO, ACPase, and SOD activities increased significantly in lead exposedcultures as compared to control. The results also emphasized that simultaneous administration of prescribed antioxidants and lead in culturesmanifested maintenance of all biochemical parameters studied nearest to control group.Conclusion: Synthetic and herbal antioxidants therapy have protective role against lead induced hepatotoxicity.Keywords: Lead toxicity, Synthetic antioxidants, Herbal antioxidant, Bacopa monnieri extract, Hepatotoxicity, Oxidative stress, Plumbism,Hepatoprotective activity, Lipid peroxidation, Superoxide dismutase

Unusual meats : how to prepare and serve them

"January, 1943""In the slaughtering and dressing of meat animals often some choice edible portins are not appreciated and may be laid aside until they have lost their freshness or they may be immediately thrown away. Brain, heart, tripe, kidney, liver, sweetbreads, spleen, tongue, head, tails, and feet are good food and may well be used to add variety to the menu. In food value, these meats supply good protein for muscles as other meats do and they also add extra minerals and vitamins which are so essential for normal growth and good health. As a group they are usually relatively inexpensive to buy and with the exception of the head, tail, and feet have no bone and little waste."--First paragraph.Flora L. Carl, Letha K. Joplin