Proton-3^{3}He elastic scattering at low energies

We present new accurate measurements of the differential cross section $\sigma(\theta)$ and the proton analyzing power $A_{y}$ for proton-$^{3}$He elastic scattering at various energies. A supersonic gas jet target has been employed to obtain these low energy cross section measurements. The $\sigma(\theta)$ distributions have been measured at $E_{p}$ = 0.99, 1.59, 2.24, 3.11, and 4.02 MeV. Full angular distributions of $A_{y}$ have been measured at $E_{p}$ = 1.60, 2.25, 3.13, and 4.05 MeV. This set of high-precision data is compared to four-body variational calculations employing realistic nucleon-nucleon (NN) and three-nucleon (3N) interactions. For the unpolarized cross section the agreement between the theoretical calculation and data is good when a $3N$ potential is used. The comparison between the calculated and measured proton analyzing powers reveals discrepancies of approximately 50% at the maximum of each distribution. This is analogous to the existing ``$A_{y}$ Puzzle'' known for the past 20 years in nucleon-deuteron elastic scattering.Comment: 22 pages, 9 figures, to be published in Physical Review C, corrected reference 4

Benchmark calculation of n-3H and p-3He scattering

The n-3H and p-3He elastic phase-shifts below the trinucleon disintegration thresholds are calculated by solving the 4-nucleon problem with three different realistic nucleon-nucleon interactions (the I-N3LO model by Entem and Machleidt, the Argonne v18 potential model, and a low-k model derived from the CD-Bonn potential). Three different methods -- Alt, Grassberger and Sandhas, Hyperspherical Harmonics, and Faddeev-Yakubovsky -- have been used and their respective results are compared. For both n-3H and p-3He we observe a rather good agreement between the three different theoretical methods. We also compare the theoretical predictions with the available experimental data, confirming the large underprediction of the p-3He analyzing power.Comment: 18 pages, 9 figure

The Ay Problem for p-3He Elastic Scattering

We present evidence that numerically accurate quantum calculations employing modern internucleon forces do not reproduce the proton analyzing power, A_y, for p-3He elastic scattering at low energies. These calculations underpredict new measured analyzing powers by approximately 30% at E_{c.m.} = 1.20 MeV and by 40% at E_{c.m.} = 1.69 MeV, an effect analogous to a well-known problem in p-d and n-d scattering. The calculations are performed using the complex Kohn variational principle and the (correlated) Hyperspherical Harmonics technique with full treatment of the Coulomb force. The inclusion of the three-nucleon interaction does not improve the agreement with the experimental data.Comment: Latex file, 4 pages, 2 figures, to be published on Phys. Rev. Let

Chronic fatigue syndrome: Harvey and Wessely's (bio)psychosocial model versus a bio(psychosocial) model based on inflammatory and oxidative and nitrosative stress pathways

<p>Abstract</p> <p>Background</p> <p>In a recently published paper, Harvey and Wessely put forward a 'biopsychosocial' explanatory model for myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), which is proposed to be applicable to (chronic) fatigue even when apparent medical causes are present.</p> <p>Methods</p> <p>Here, we review the model proposed by Harvey and Wessely, which is the rationale for behaviourally oriented interventions, such as cognitive behaviour therapy (CBT) and graded exercise therapy (GET), and compare this model with a biological model, in which inflammatory, immune, oxidative and nitrosative (IO&NS) pathways are key elements.</p> <p>Discussion</p> <p>Although human and animal studies have established that the pathophysiology of ME/CFS includes IO&NS pathways, these abnormalities are not included in the model proposed by Harvey and Wessely. Activation of IO&NS pathways is known to induce fatigue and somatic (F&S) symptoms and can be induced or maintained by viral and bacterial infections, physical and psychosocial stressors, or organic disorders such as (auto)immune disorders. Studies have shown that ME/CFS and major depression are both clinical manifestations of shared IO&NS pathways, and that both disorders can be discriminated by specific symptoms and unshared or differentiating pathways. Interventions with CBT/GET are potentially harmful for many patients with ME/CFS, since the underlying pathophysiological abnormalities may be intensified by physical stressors.</p> <p>Conclusions</p> <p>In contrast to Harvey and Wessely's (bio)psychosocial model for ME/CFS a bio(psychosocial) model based upon IO&NS abnormalities is likely more appropriate to this complex disorder. In clinical practice, we suggest physicians should also explore the IO&NS pathophysiology by applying laboratory tests that examine the pathways involved.</p

Evaluation of Commercial Probiotic Products

Although there is a vast number of probiotic products commercially available due to their acceptability and increasing usage, their quality control has continuously been a major concern. This study aimed to assess some commercially available probiotics on the UK market for content in relation to their label claim. Seven products were used for the study. The bacteria content were isolated, identified and enumerated on selective media. The results revealed that all products evaluated contained viable probiotic bacteria but only three out of the seven products (43%) contained the claimed culture concentration or more. None of the multispecies product contained all the labelled probiotic bacteria. Misidentification of some species occurred. The results concurred with previous studies and showed that quality issues with commercial probiotics remain. Since probiotic activity is linked with probiotic concentration and is strain specific, the need exist for a global comprehensive legislation to control the quality of probiotics whose market is gaining huge momentum

Evidence-based guidelines for use of probiotics in preterm neonates

<p>Abstract</p> <p>Background</p> <p>Current evidence indicates that probiotic supplementation significantly reduces all-cause mortality and definite necrotising enterocolitis without significant adverse effects in preterm neonates. As the debate about the pros and cons of routine probiotic supplementation continues, many institutions are satisfied with the current evidence and wish to use probiotics routinely. Because of the lack of detail on many practical aspects of probiotic supplementation, clinician-friendly guidelines are urgently needed to optimise use of probiotics in preterm neonates.</p> <p>Aim</p> <p>To develop evidence-based guidelines for probiotic supplementation in preterm neonates.</p> <p>Methods</p> <p>To develop core guidelines on use of probiotics, including strain selection, dose and duration of supplementation, we primarily used the data from our recent updated systematic review of randomised controlled trials. For equally important issues including strain identification, monitoring for adverse effects, product format, storage and transport, and regulatory hurdles, a comprehensive literature search, covering the period 1966-2010 without restriction on the study design, was conducted, using the databases PubMed and EMBASE, and the proceedings of scientific conferences; these data were used in our updated systematic review.</p> <p>Results</p> <p>In this review, we present guidelines, including level of evidence, for the practical aspects (for example, strain selection, dose, duration, clinical and laboratory surveillance) of probiotic supplementation, and for dealing with non-clinical but important issues (for example, regulatory requirements, product format). Evidence was inadequate in some areas, and these should be a target for further research.</p> <p>Conclusion</p> <p>We hope that these evidence-based guidelines will help to optimise the use of probiotics in preterm neonates. Continued research is essential to provide answers to the current gaps in knowledge about probiotics.</p

ICAR: endoscopic skull‐base surgery

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