2,652 research outputs found
T. H. McK. Clough , ed., Oakham Lordshold in 1787: A Map and Survey of Lord Winchilsea's Oakham Estate. Rutland Local History and Record Society Occasional Publication, number 12, Oakham, 2016. 104 pp. £10. 9780907464556.
T. H. McK. Clough , ed., Oakham Lordshold in 1787: A Map and Survey of Lord Winchilsea's Oakham Estate. Rutland Local History and Record Society Occasional Publication, number 12, Oakham, 2016. 104 pp. £10. 9780907464556
Limitations of commonly used spectrophotometric assay methods for phosphoenolypyruvate carboxykinase activity in crude extracts of muscle
Branched-chain amino acid metabolism and alanine formation in rat diaphragm muscle in vitro. Effects of dichloroacetate
Regulation of hepatic l-serine dehydratase and l-serine-pyruvate aminotransferase in the developing neonatal rat
One-carbon metabolism in cancer
Cells require one-carbon units for nucleotide synthesis, methylation and reductive metabolism, and these pathways support the high proliferative rate of cancer cells. As such, anti-folates, drugs that target one-carbon metabolism, have long been used in the treatment of cancer. Amino acids, such as serine are a major one-carbon source, and cancer cells are particularly susceptible to deprivation of one-carbon units by serine restriction or inhibition of de novo serine synthesis. Recent work has also begun to decipher the specific pathways and sub-cellular compartments that are important for one-carbon metabolism in cancer cells. In this review we summarise the historical understanding of one-carbon metabolism in cancer, describe the recent findings regarding the generation and usage of one-carbon units and explore possible future therapeutics that could exploit the dependency of cancer cells on one-carbon metabolism
Embedded Stellar Clusters in the W3/W4/W5 Molecular Cloud Complex
We analyze the embedded stellar content in the vicinity of the W3/W4/W5 HII
regions using the FCRAO Outer Galaxy 12CO(J=1-0) Survey, the IRAS Point Source
Catalog, published radio continuum surveys, and new near-infrared and molecular
line observations. Thirty-four IRAS Point Sources are identified that have
far-infrared colors characteristic of embedded star forming regions, and we
have obtained K' mosaics and 13CO(J=1-0) maps for 32 of them. Ten of the IRAS
sources are associated with an OB star and 19 with a stellar cluster, although
three OB stars are not identified with a cluster. Half of the embedded stellar
population identified in the K' images is found in just the 5 richest clusters,
and 61% is contained in IRAS sources associated with an embedded OB star. Thus
rich clusters around OB stars contribute substantially to the stellar
population currently forming in the W3/W4/W5 region. Approximately 39% of the
cluster population is embedded in small clouds with an average mass of ~130 Mo
that are located as far as 100 pc from the W3/W4/W5 cloud complex. We speculate
that these small clouds are fragments of a cloud complex dispersed by previous
episodes of massive star formation. Finally, we find that 4 of the 5 known
embedded massive star forming sites in the W3 molecular cloud are found along
the interface with the W4 HII region despite the fact that most of the
molecular mass is contained in the interior regions of the cloud. These
observations are consistent with the classical notion that the W4 HII region
has triggered massive star formation along the eastern edge of the W3 molecular
cloud.Comment: to appear in ApJS, see http://astro.caltech.edu/~jmc/papers/w
First Passage Properties of the Erdos-Renyi Random Graph
We study the mean time for a random walk to traverse between two arbitrary
sites of the Erdos-Renyi random graph. We develop an effective medium
approximation that predicts that the mean first-passage time between pairs of
nodes, as well as all moments of this first-passage time, are insensitive to
the fraction p of occupied links. This prediction qualitatively agrees with
numerical simulations away from the percolation threshold. Near the percolation
threshold, the statistically meaningful quantity is the mean transit rate,
namely, the inverse of the first-passage time. This rate varies
non-monotonically with p near the percolation transition. Much of this behavior
can be understood by simple heuristic arguments.Comment: 10 pages, 9 figures, 2-column revtex4 forma
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