The Problem of Legitimacy in the European Polity. Is Democratization the Answer?

The authors discuss potential sources of legitimacy of the EU, i. e. of the normative bindingness of its decisions. After rejecting the views that such legitimacy is either not needed, not feasible, or provided for already, they focus upon the corrosive impact of the EU upon democratic legitimacy within member states. Brussels-based 'governance' is essentially uncontested and can hardly provide for the legitimacy that results from the interplay between government and opposition within nation states. The problem boils down to achieving legitimacy in the absence of the political community of a 'demos'. The paper outlines a solution to this problem that relies on the apparently oxymoronic model of a 'republican empire' - a political community, that is, which is held together not by the bonds of some presumed sameness, but, to the contrary, by the shared contractual recognition of the dissimilarity of its constituent parts from which legitimacy can flow.democracy; legitimacy; diversity/homogeneity; governance; democratization

Curvature estimates for Weingarten hypersurfaces in Riemannian manifolds

We prove curvature estimates for general curvature functions. As an application we show the existence of closed, strictly convex hypersurfaces with prescribed curvature $F$, where the defining cone of $F$ is \C_+. $F$ is only assumed to be monotone, symmetric, homogeneous of degree 1, concave and of class C^{m,\al}, $m\ge4$.Comment: 9 pages, v2:final version, to be publishe

Conformal Theory of M2, D3, M5 and `D1+D5' Branes

The bosonic actions for M2, D3 and M5 branes in their own d-dimensional near-horizon background are given in a manifestly SO(p+1,2) x SO(d-p-1) invariant form (p=2,3,5). These symmetries result from a breakdown of ISO(d,2) (with d=10 for D3 and d=11 for M2 and M5) symmetry by the Wess-Zumino term and constraints. The new brane actions, reduce after gauge-fixing and solving constraints to (p+1) dimensional interacting field theories with a non-linearly realized SO(p+1,2) conformal invariance. We also present an interacting two-dimensional conformal field theory on a D-string in the near-horizon geometry of a D1+D5 configuration.Comment: 32 pages, two figures, Latex. A version to appear in JHEP. A comment is added on infinite dimensional Kac-Moody type symmetry of D1+D5 system observed by Brandt, Gomis, Sim'o

An increase in TcT_c under hydrostatic pressure in the superconducting doped topological insulator Nb0.25_{0.25}Bi2_2Se3_3

We report an unexpected positive hydrostatic pressure derivative of the superconducting transition temperature in the doped topological insulator \NBS via $dc$ SQUID magnetometry in pressures up to 0.6 GPa. This result is contrary to reports on the homologues \CBS and \SBS where smooth suppression of $T_c$ is observed. Our results are consistent with recent Ginzburg-Landau theory predictions of a pressure-induced enhancement of $T_c$ in the nematic multicomponent $E_u$ state proposed to explain observations of rotational symmetry breaking in doped Bi$_2$Se$_3$ superconductors.Comment: 5 pages, 5 figure

RnaseIII and T4 Polynucleotide Kinase Sequence Biases and Solutions During RNA-Seq Library Construction

Background: RNA-seq is a next generation sequencing method with a wide range of applications including single nucleotide polymorphism (SNP) detection, splice junction identification, and gene expression level measurement. However, the RNA-seq sequence data can be biased during library constructions resulting in incorrect data for SNP, splice junction, and gene expression studies. Here, we developed new library preparation methods to limit such biases. Results: A whole transcriptome library prepared for the SOLiD system displayed numerous read duplications (pile-ups) and gaps in known exons. The pile-ups and gaps of the whole transcriptome library caused a loss of SNP and splice junction information and reduced the quality of gene expression results. Further, we found clear sequence biases for both 5' and 3' end reads in the whole transcriptome library. To remove this bias, RNaseIII fragmentation was replaced with heat fragmentation. For adaptor ligation, T4 Polynucleotide Kinase (T4PNK) was used following heat fragmentation. However, its kinase and phosphatase activities introduced additional sequence biases. To minimize them, we used OptiKinase before T4PNK. Our study further revealed the specific target sequences of RNaseIII and T4PNK. Conclusions: Our results suggest that the heat fragmentation removed the RNaseIII sequence bias and significantly reduced the pile-ups and gaps. OptiKinase minimized the T4PNK sequence biases and removed most of the remaining pile-ups and gaps, thus maximizing the quality of RNA-seq data.National Institute on Alcohol Abuse and Alcoholism (NIAAA) AA12404, AA019382, AA020926, AA016648National Institutes of Health (NIH) R01 GM088344Waggoner Center for Alcohol and Addiction Researc

The Role of Exercise-Induced Myokines in Muscle Homeostasis and the Defense against Chronic Diseases

Chronic inflammation is involved in the pathogenesis of insulin resistance, atherosclerosis, neurodegeneration, and tumour growth. Regular exercise offers protection against type 2 diabetes, cardiovascular diseases, colon cancer, breast cancer, and dementia. Evidence suggests that the protective effect of exercise may to some extent be ascribed to the antiinflammatory effect of regular exercise. Here we suggest that exercise may exert its anti-inflammatory effect via a reduction in visceral fat mass and/or by induction of an anti-inflammatory environment with each bout of exercise. According to our theory, such effects may in part be mediated via muscle-derived peptides, so-called “myokines”. Contracting skeletal muscles release myokines with endocrine effects, mediating direct anti-inflammatory effects, and/or specific effects on visceral fat. Other myokines work locally within the muscle and exert their effects on signalling pathways involved in fat oxidation and glucose uptake. By mediating anti-inflammatory effects in the muscle itself, myokines may also counteract TNF-driven insulin resistance. In conclusion, exercise-induced myokines appear to be involved in mediating both systemic as well as local anti-inflammatory effects

Microscopic calculation of the phonon dynamics of Sr2_{2}RuO4_{4} compared with La2_{2}CuO4_{4}

The phonon dynamics of the low-temperature superconductor Sr$_{2}$RuO$_{4}$ is calculated quantitatively in linear response theory and compared with the structurally isomorphic high-temperature superconductor La$_{2}$CuO$_{4}$. Our calculation corrects for a typical deficit of LDA-based calculations which always predict a too large electronic $k_{z}$-dispersion insufficient to describe the c-axis response in the real materials. With a more realistic computation of the electronic band structure the frequency and wavevector dependent irreducible polarization part of the density response function is determined and used for adiabatic and nonadiabatic phonon calculations. Our analysis for Sr$_{2}$RuO$_{4}$ reveals important differences from the lattice dynamics of $p$- and $n$-doped cuprates. Consistent with experimental evidence from inelastic neutron scattering the anomalous doping related softening of the strongly coupling high-frequency oxygen bond-stretching modes (OBSM) which is generic for the cuprate superconductors is largely suppressed or completely absent, respectively, depending on the actual value of the on-site Coulomb repulsion of the Ru4d orbitals. Also the presence of a characteristic $\Lambda_{1}$-mode with a very steep dispersion coupling strongly with the electrons is missing in Sr$_{2}$RuO$_{4}$. Moreover, we evaluate the possibility of a phonon-plasmon scenario for Sr$_{2}$RuO$_{4}$ which has been shown recently to be realistic for La$_{2}$CuO$_{4}$. In contrast to La$_{2}$CuO$_{4}$ in Sr$_{2}$RuO$_{4}$ the very low lying plasmons are overdamped along the c-axis.Comment: 30 pages, 16 figures, 4 tables, 33 reference

Micro-device for coupling, multiplexing and demultiplexing using elliptical-core two-mode fiber

We propose and demonstrate experimentally a fiber optic micro-device that is capable of tunably splitting, multiplexing, and demultiplexing optical signals using elliptical-core two-mode optical fiber. A crosstalk of 15 dB with an insertion loss of 1.2 dB was obtained