The Invincible (1758) site: an integrated geophysical assessment

Chirp sub-bottom profiler and repeat sidescan sonar imaging of the Invincible wreck site (1758) in the Solent (U.K.), interpretation, and implications for management of the site

Raped Abroad: Extraterritorial Application of Title IX for American University Students Sexually Assaulted While Studying Abroad

Female college students who study abroad are five times more likely to be raped than their counterparts who remain on their domestic campuses. Students raped or sexually assaulted on or around campuses in the United States can seek a remedy under Title IX, which provides administrative and judicial remedies. Very few federal cases have ever addressed whether Title IX applies extraterritorially to allegations of sex discrimination occurring abroad, and courts have reached different results in these cases. Moreover, no federal circuit has ever addressed the issue. This Note explores whether Title IX applies extraterritorially to students raped while studying abroad. After concluding that the text of the statute fails to overcome the presumption against extraterritorial application, this Note analyzes whether Congress should amend Title IX to explicitly overcome this presumption, concluding that it should not. Instead, this Note presents alternative solutions for preventing and responding to sexual violence during study abroad programs, such as federal disclosure legislation and an amendment to the Clery Act that mandates reporting of crimes that occur during study abroad programs

High-temperature oxidation of nickel-based alloys and estimation of the adhesion strength of resulting oxide layers

The kinetics of isothermal oxidation (1100°C) of commercial nickel-based alloys with different content of sulfur (0.22–3.2 wt ppm) is studied. The adhesion strength in a metal/oxide system is estimated as a function of sulfur content and duration of high-temperature exposure. The scratch-test technique is proposed to quantitatively estimate the work of adhesion of resulting oxide films. It is found that the film microstructure is composed of an inner α-Al2O3 layer and an outer NiAl2O4 spinel layer, which are separated by discrete inclusions of TiO2. Residual stresses in the oxide film are experimentally determined by X-ray diffraction. spinel layer, which are separated by discrete inclusions of TiO2. Residual stresses in the oxide film are experimentally determined by X-ray diffractio

Genomic variations associated with attenuation in Mycobacterium avium subsp paratuberculosis vaccine strains

BACKGROUND: Mycobacterium avium subspecies paratuberculosis (MAP) whole cell vaccines have been widely used tools in the control of Johne's disease in animals despite being unable to provide complete protection. Current vaccine strains derive from stocks created many decades ago; however their genotypes, underlying mechanisms and relative degree of their attenuation are largely unknown. RESULTS: Using mouse virulence studies we confirm that MAP vaccine strains 316 F, II and 2e have diverse but clearly attenuated survival and persistence characteristics compared with wild type strains. Using a pan genomic microarray we characterise the genomic variations in a panel of vaccine strains sourced from stocks spanning over 40 years of maintenance. We describe multiple genomic variations specific for individual vaccine stocks in both deletion (26-32 Kbp) and tandem duplicated (11-40 Kbp) large variable genomic islands and insertion sequence copy numbers. We show individual differences suitable for diagnostic differentiation between vaccine and wild type genotypes and provide evidence for functionality of some of the deleted MAP-specific genes and their possible relation to attenuation. CONCLUSIONS: This study shows how culture environments have influenced MAP genome diversity resulting in large tandem genomic duplications, deletions and transposable element activity. In combination with classical selective systematic subculture this has led to fixation of specific MAP genomic alterations in some vaccine strain lineages which link the resulting attenuated phenotypes with deficiencies in high reactive oxygen species handling