Ultrashort Bradycardic Effect of Newly Synthesized Compounds

Changes in the heart rate induced by four different doses of two newly synthesized potential ultrashort-action antagonists of beta adrenergic receptors were tested in 90 male laboratory Wistar rats. The isoprenaline-induced tachycardia model was used. Their effects were compared with those of esmolol. In the second part of the study, approximate electro-physiological measurements were made in vitro to assess the influence of the compounds tested on ion membrane currents in isolated ventricular cardiomyocytes. Both compounds demonstrated significant bradycardic effects in all concentrations tested compared with the control group, but they differed in the time of the onset of their action. Both newly synthesized compounds induced blockade of the fast sodium current (INa) and potassium currents (Ito, IK1, IK,end)

Magnetooptics in Charge Uncompensated Garnet CaxY3-xFe5O12

The properties of compensating centres in Ca2+ substituted yttrium iron garnet CaxY3-xFe5O12, 0≤ x ≤ 0.39 have been investigated using magnetooptical spectroscopy and magnetization measurements. The Faraday rotation and MCD were measured in the spectral range from 0.5 to 2.5 eV and at temperatures from 6 to 380 K. Different centres were detected and the effects of their localization at low temperatures are discussed

Influence of tobacco consumption, age and sex on cardiovascular risk levels.

[eng] Introduction: For the World Health Organization, cardiovascular disease is responsible for the highest number of deaths in the world. Material and methods: Descriptive and transversal study in 418343 workers from different Spanish regions in which the influence of sociodemographic variables such as age and sex and tobacco use is valued on the values of different parameters related to cardiovascular risk. Parameters related to overweight and obesity, atherogenic indices, risk scales such as SCORE, REGICOR or vascular age, fatty liver risk scales and metabolic syndrome are determined. Results: In smokers the prevalence of altered values is lower on scales related to overweight and obesity, atherogenic indices, high blood pressure, lipid profile, metabolic syndrome and fatty liver scales. Cardiovascular risk scales such as SCORE, REGICOR and vascular age have worse values in smokers. Conclusions: Age and sex influence the appearance of all the parameters studied .There is variability in the results of cardiovascular risk, obesity and fatty liver when related to tobacco consumption