Optimal polymer slugs injection curves

In the paper we study miscible injection of liquids with decreasing viscosity in two-dimensional geometry. Polymer flooding of oil fields is our prototype model. Based on several one-dimensional approximate models we give rigorous formulation of the graded viscosity banks (GVB) technology which helps to save polymer by injecting several slugs with gradual decrease of viscosity instead of one slug. Limiting injection curves when number of slugs tends to infinity is calculated

FABRICATION OF BIOADHESIVE OCUSERT WITH DIFFERENT POLYMERS: ONCE A DAY DOSE

Objective: The objective of this current study is to fabricate ocuserts to control the drug release from chosen bioadhesive polymeric matrixes to enhance patient compliance. Ciprofloxacin HCl (CFX HCl) was selected as a model drug.Methods: Different bioadhesive polymers with different film forming capabilities namely Hydroxy Propyl Methyl Cellulose (HPMC K4M), Poly Vinyl Alcohol (PVA), Sodium Carboxy Methyl Cellulose (Na CMC), Hydroxy Propyl Cellulose (HPC), Sodium Alginate (Na Alg.), pullulan and Xanthan Gum (XG) in different ratios were used in fabricating ocuserts using solvent-casting technique. Propylene Glycol (PG) was used as a plasticizer to facilitate the fabrication process. Characterization tests of the developed ocuserts were performed as well as bioadhesive tests and in vitro release studies of the incorporated drug. The obtained results were analysed using different release kinetic models. Stability of the selected ocuserts was investigated at 40±0.5 °C and 75±5% Relative Humidity (RH) for three months' storage period. In vivo ocular irritation test was performed to investigate the safety of the formula in rabbits' eyes as well as to test the release profile and thus to estimate In vitro In vivo correlation.Results: All the prepared ocuserts showed the uniformity of film characterization and bioadhesion strength ranged from 240±66 and 158±52dyne/cm2. Selected formula from the in vitro release study tested for in vivo study showed the slow release of ciprofloxacin drug up to 24 h with no signs of eye irritancy. Results for In vitro In vivo correlation showed an excellent correlation with R2 value of 0.9982.Conclusion: PVA based ocuserts proven to be a promising once-daily, effective and safe ocular delivery system of the drug

ASSESSMENT OF PSYCHOPHYSIOLOGICAL CONDITION OF VARIOUS LEVELS OF MENTAL HEALTH IN PERSONS OF HAZARDOUS OCCUPATION

At Hie present time, studying psychophysiological condition of levels of mental adaptation by means of objective indices is especially actual. Therefore, the identification and assessment of the indices characterizing the functional condition of an organism will allow the expert to decide on the level of mental adaptation. We examined 75 respondents which were divided into groups in correspondence with V.Y. Semke's concept. Primary diagnostic measures included clinical and psychological methods, the assessment of the functional condition of nervous system, short record of variability of cardiac rhythm. Features of psychophysiological condition of processes of regulation and functioning of ground levels of mental health in persons of hazardous occupation are studied. /Is a result of the conducted research, we revealed the reliable changes in the psychoadaptation and psychodisadaptation state in vegetative system of supporting of the processes of regulation of an organism in group (p < 0,05) (according to the indices of spectral analysis of cardiac rhythm and variation ofpulsometry according to R.M. Bayevsky). The tension index increased from 45,92 ± 31,81 to 347,94 ± 434,01 (p < 0,05). Reliable negative dynamics of change of clinical, psychological and psychophysiological indexes is shown upon transition from the first to the third level of mental health (p < 0,05)

Formation of Amyloid-Like Fibrils by Y-Box Binding Protein 1 (YB-1) Is Mediated by Its Cold Shock Domain and Modulated by Disordered Terminal Domains

YB-1, a multifunctional DNA- and RNA-binding nucleocytoplasmic protein, is involved in the majority of DNA- and mRNA-dependent events in the cell. It consists of three structurally different domains: its central cold shock domain has the structure of a β-barrel, while the flanking domains are predicted to be intrinsically disordered. Recently, we showed that YB-1 is capable of forming elongated fibrils under high ionic strength conditions. Here we report that it is the cold shock domain that is responsible for formation of YB-1 fibrils, while the terminal domains differentially modulate this process depending on salt conditions. We demonstrate that YB-1 fibrils have amyloid-like features, including affinity for specific dyes and a typical X-ray diffraction pattern, and that in contrast to most of amyloids, they disassemble under nearly physiological conditions

Students Worksheet Based On Anti Corruption And Higher Order Thinking Skills (Swachots): Mengembangkan Pembelajaran Lingkungan Abad 21

The topic of river pollution is a learning topic that requires Higher Order Thinking Skills (HOTS). Environmental problems also combine with other problems, one of them is corruption cases in environmental issues is also of particular concern, so the need to instill anti-corruption values. The purpose of this study was to develop Students Worksheet based on Anti Corruption and Higher Order Thinking Skills (SWACHOTS) in environmental learning. The research method used is Research and development based on Borg &amp; Gall (2003). The study was conducted on 12-18 October 2018 in Elementary School 2 of Jatimulya and Junior High School 1 South Tambun, Bekasi. The results showed that the worksheets developed were valid and suitable for environmental learning for Elementary students and Junior High School students with an average score of 3.47. This is because the presentation of SWACHOTS is simple but full of HOTS and anti-corruption values. The conclusion is that developed worksheets are valid and suitable for use in environmental learning

In-situ transesterification reaction for biodiesel production

Biodiesel synthesis can be conducted using transesterification of triglycerides in the presence of catalyst and alcohol. The oil extraction and transesterification steps are carried out separately for the conventional biodiesel production, which can result in longer time requirement and using different operating units. An alternative to the conventional method is the in-situ transesterification process, where it combines both extraction and transesterification processes into a single-step process. Biomass feedstock is used directly in the in-situ method, which can reduce the time required to obtain biodiesel, as well as conduct both processes simultaneously. The single-step process can be integrated with other technology such as microwave irradiation to enhance biodiesel productivity. Furthermore, the in-situ transesterification process involving microalgae feedstock has started to gain attention from researchers, where microalgae biomass is utilized as a feedstock for the in-situ transesterification process without the lipid extraction step prior to the transesterification reaction. This chapter focused on the in-situ transesterification process for biodiesel production, particularly for both catalytic and non-catalytic processes, and also the application of the single-step process for biodiesel synthesis from microalgae