Preeclampsia and MicroRNAs

Preeclampsia is a critical gestational condition that threatens the life of both mother and child. One of the most serious aspects of preeclampsia hampering both clinical management and scientific understanding is that there are, as yet, no early warning signs or risk markers. The discovery of microRNAs (miRNAs), tiny post-transcriptional regulators of gene expression, offers potentially fertile ground for developing such markers. The current state of knowledge about miRNAs in preeclampsia is presented along with information regarding miRNA detection in peripheral fluids that could lead to minimally invasive risk assessment

Evaluation of the VNTR region in the IDO promoter in women with preeclampsia

Indoleamine 2,3 – dioxygenase (IDO) is an enzyme that aids in immunosuppression and tolerance. Previous studies have shown decreased IDO activity in pregnancies affected by preeclampsia, but the mechanism for this altered activity is unknown. Our study was designed to analyze the promoter region of IDO in preeclamptic and control women and identify the frequency of a VNTR genotype that has been shown to be significantly correlated with tryptophan levels in women; a surrogate marker for IDO activity

Global fetal DNA methylation and birth outcomes in obese women

Pregnant women who are obese are more likely to have gestational diabetes, gestational hypertension, pre-eclampsia, macrosomia, operative vaginal delivery, and cesarean delivery. Obesity also has adverse implications for the neonate. Congenital anomalies are more common in children born to obese women. These include neural tube defects, gastroschisis, cardiovascular anomalies, and others. Although the connection between maternal obesity and chronic health conditions has been described, the mechanism by which this occurs is less well understood. Changes to the epigenetic structure of offspring DNA have been proposed as one such mechanism

Effects of biological factors on the expression of arginine vasopressin receptors

Arginine vasopressin (AVP) is a hormone that functions to regulate blood pressure and bodily fluid homeostasis. Vasopressin has three main receptors AVPR1a, AVPR1b, and AVPR2 which were investigated in this project along with OXTR, LNPEP, and CUL5. AVPR1a functions in the smooth muscle and causes vasoconstriction, AVPR1b functions in the pituitary helping to regulate adrenocorticotropic hormone release, and AVPR2 is expressed highly in the kidneys and works to concentrate urine. This project investigates how these various receptors are expressed with different factors related to pregnancy such as, sex of the baby, chronically hypertensive mothers, and gestational age at deliver

The relationship between obesity, pregnancy, and levels of indoleamine 2,3-dioxygenase

For a successful pregnancy to occur, foreign genetic material such as the allogeneic fetus must be tolerated within the maternal host. Indoleamine 2,3-dioxygenase (IDO) is an enzyme induced by pro-inflammatory cytokines that has been shown to be key to this process. Obesity as a pro-inflammatory state is associated with poor obstetric outcomes. The primary objective of this study is to investigate the relationship between obesity and IDO activity

A predictive model for serous epithelial ovarian cancer chemo-response using clinical characteristics

One of the prognostic factors most highly associated with ovarian cancer survival is response to initial chemotherapy. Current prediction models of chemo-response built with comprehensive molecular datasets, like The Cancer Genome Atlas (TCGA), could be improved by including clinical and outcomes data designed to study response to treatment. The objective of this study was to create a prediction model of ovarian cancer chemo-response using clinical-pathological features, and to compare its performance with a similar TCGA clinical model

Planets in Stellar Clusters Extensive Search. III. A search for transiting planets in the metal-rich open cluster NGC 6791

We have undertaken a long-term project, Planets in Stellar Clusters Extensive Search (PISCES), to search for transiting planets in open clusters. In this paper we present the results for NGC 6791 -- a very old, populous, metal rich cluster. We have monitored the cluster for over 300 hours, spread over 84 nights. We have not detected any good transiting planet candidates. Given the photometric precision and temporal coverage of our observations, and current best estimates for the frequency and radii of short-period planets, the expected number of detectable transiting planets in our sample is 1.5. We have discovered 14 new variable stars in the cluster, most of which are eclipsing binaries, and present high precision light curves, spanning two years, for these new variables and also the previously known variables.Comment: 18 pages LaTeX, including 11 figures and 6 tables. Limb darkening included in the computation of the planet detection efficiency. Version with full resolution figures available through ftp at ftp://cfa-ftp.harvard.edu/pub/bmochejs/PISCES/papers/3_N6791