HISTORIC REVIEW ON MODERN HERBAL NANOGEL FORMULATION AND DELIVERY METHODS

Chemistry deals with herbal constituents are often coined as phytochemistry. Herbal constituents have profound improvements in drug discovery for several existing diseases. Many of these constituents are restricted from pharmaceutical discoveries due to two important reasons: pharmacodynamics and pharmacokinetics. There are many new technological strategies and comparisons have been studied to improve the herbal discoveries in the pharmaceutical market. This review paper will highlight historical evidence of nanogels which is the most important strategy applied to several herbal medicines with high patience compliance, delivery rate, and efficiency. Nanogels are nanoparticles combined with cross-linked polymer networks with desirable features to carry hydrophilic or hydrophobic drugs in a more stable condition. Nanogels are highly preferred substances for herbal medicine in terms of stability and rapid response to the external stimuli factors. Nanogel can facilitate the herbal products with higher cellular penetration than existing and hence, it proves to be the new dimension for both oral and transdermal drug delivery for several unmet diseases like cancer, diabetes, and chronic disorders. By the way, including the recent technological constituents to herbal drugs, it can possess high bioavailability, low toxicity and enhance the sustained release

Identifying clinically significant novel drug candidate for highly prevalent Alzheimer's disease

618-623Pharmacokinetics is very important in target validation and in shifting a lead compound into a drug. It is a cumbersome process in clinical research. A quantitative personation based on computed, pharmacokinetics, physicochemical properties, ILOGP, drug-likeness, medicinal chemistry friendliness, bioavailability radar and BOILED-Egg for all the synthesized, 6 novel compounds have been assessed using Swiss ADME. An effective drug can be produced from the physicochemical properties discussed in this model. The physicochemical properties of all designed Schiff bases of curcumin have been found to be optimal and so, they are perceived to have acceptable oral absorption and adequate permeability. All the monomers obeyed the rule of five by Lipinski and the oral bioavailability is accounted worldwide. The desired set of monomers have been enhanced by effective ADME screening and molecular simulation methods with Microtubuleassociated protein tau (MAPT) (PDB code: 10636) receptor could represent favourable building blocks as preferable chemotherapeutic factor in resistance to Alzheimers disease

Identifying clinically significant novel drug candidate for highly prevalent Alzheimer's disease

Pharmacokinetics is very important in target validation and in shifting a lead compound into a drug. It is a cumbersome process in clinical research. A quantitative personation based on computed, pharmacokinetics, physicochemical properties, ILOGP, drug-likeness, medicinal chemistry friendliness, bioavailability radar and BOILED-Egg for all the synthesized, 6 novel compounds have been assessed using Swiss ADME. An effective drug can be produced from the physicochemical properties discussed in this model. The physicochemical properties of all designed Schiff bases of curcumin have been found to be optimal and so, they are perceived to have acceptable oral absorption and adequate permeability. All the monomers obeyed the rule of five by Lipinski and the oral bioavailability is accounted worldwide. The desired set of monomers have been enhanced by effective ADME screening and molecular simulation methods with Microtubuleassociated protein tau (MAPT) (PDB code: 10636) receptor could represent favourable building blocks as preferable chemotherapeutic factor in resistance to Alzheimers disease

Mechanical, Thermal and Flammability Properties of Pultruded Soy-Based Nanocomposites

Nanocomposites were synthesized using a soy-based epoxy resin, which was prepared by the process of transesterfication and epoxidation of regular food grade soybean oil and montmorillonite clay. High shear mixer and sonication were used to disperse the nanoclay into the soy-based epoxy resin. Glass/epoxy-clay nanocomposites were manufactured using the pultrusion process. The dispersion of clay in the resin was evaluated using wide angle X-ray diffraction. Flexural and impact tests were performed to evaluate the structural performance of these new glass fiber reinforced nanocomposites. Thermal properties, such as onset of decomposition and degradative heat flow, were determined by thermogravimetric analysis. The results show significant improvements in mechanical and thermal properties for glass fiber reinforced soy-based pultruded nanocomposites. The improved properties can be attributed to increased interfacial surface area and exfoliated morphology. Cone calorimetry was used to evaluate the flammability resistance of the nanocomposites. The soy based nanocomposites are environmentally friendly and appear suitable for structural applications

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Ultrasonic and viscometric study of molecular interactions of antibiotic doxycycline hycalte

Dilute solution viscometric (DSV) and ultrasonic techniques are employed to investigate the aqueous solutions of antibiotic doxycycline hyclate for different molar concentrations around the physiological temperatures. The viscometric Huggin’s plots and interaction parameter identify the existence of dimerization of doxycycline at 303.15 K and the dominance of solute-solvent interaction at higher temperatures. The ultrasonic velocity and the thermo acoustic parameters confirm the results obtained by DSV. For further confirmation of dimerization, the stacking parameter (D) was obtained through the Hemme’s isodesmic model. The values of ‘D claim the dimerization of doxycycline at ambient temperature and dissociation among the antibiotic molecules at 308.15 and 313.15 K. The ultrasonic velocity derivative limiting slope (A) claims solute-solute and solute-solvent interactions at ambient and elevated temperatures, respectively. The stacking constant (K) decreases with increase of temperature. The structure change of solvent is discussed