8 research outputs found
Long-term expression of melanopsin and channelrhodopsin causes no gross alterations in the dystrophic dog retina
No full textInternational audienceSeveral preclinical studies have investigated the potential of algal channelrhodopsin and human melanopsin as optogenetic tools for vision restoration. In the present study, we assessed the potentially deleterious effects of long-term expression of these optogenes on the diseased retina in a large animal model of retinal degeneration, the RPE65-deficient Briard dog model of Leber congenital amaurosis. Intravitreal injection of adeno-associated virus vectors expressing channelrhodopsin and melanopsin had no effect on retinal thickness over a 16-month period post injection. Our data support the safety of the optogenetic approach for the treatment of blindness
Long-term expression of melanopsin and channelrhodopsin causes no gross alterations in the dystrophic dog retina
No full textSeroprevalence of Rift Valley fever virus in cattle in the Democratic Republic of the Congo
No full textExosome-associated AAV2 vector mediates robust gene delivery into the murine retina upon intravitreal injection
No full textDeveloping Single Nucleotide Polymorphism (SNP) Markers for the Identification of Coffee Germplasm
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