4,626 research outputs found
Mineral Admixtures, Curing, and Concrete Shrinkage – An Update
Work currently underway at the University of Kansas to evaluate free shrinkage of concrete as a function of the length of curing prior to drying, mineral admixtures as a replacement for portland cement, and aggregate type is presented. Silica fume, ground-granulated blast furnace slag (GGBFS), and fly ash at two levels of replacement are evaluated with a high-absorption coarse aggregate (2.5 to 3.0%) and a low-absorption coarse aggregate (less than 0.7%). The results show that when cast with a high-absorption coarse aggregate, the addition of either silica fume or GGBFS results in a reduction in shrinkage at all ages, while the addition of fly ash increases early-age shrinkage and does not have a significant effect on long-term shrinkage. For mixtures containing a low-absorption coarse aggregate, the addition of silica fume or GGBFS results in increased early-age shrinkage if the specimens are only cured for seven days. These same mixtures exhibit reduced shrinkage at all ages when the curing period is doubled from seven to fourteen days. In either case the addition of fly ash increases shrinkage at all ages. Based on these results, it appears that the high-absorption limestone provides internal curing water, which results in a reduction in the shrinkage of mixtures containing GGBFS or silica fume
Alumina and Synthesis Intermediates Derived from Diethylkaluminum Amide, Benzaldehyde and Water
The reaction of diethylaluminum amide [Et2AINH2] with benzaldehyde in toluene produces a solution of ethylaluminoxane polymer [EtAlO] and hydrobenzamide [PhCH=NCH(Ph)N=CHPh]. Alumina then is precipitated by the addition of water. Transition aluminas that may be useful in heterogeneous catalyst applications are obtained after calcining. Details of the chemistry of solution intermediates according to 1H NMR and the properties of the alumina product according to surface area analyses and powder x-ray diffraction are described
Capture Velocity for a Magneto-Optical Trap in a Broad Range of Light Intensity
In a recent paper, we have used the dark-spot Zeeman tuned slowing technique
[Phys. Rev. A 62, 013404-1, (2000)] to measure the capture velocity as a
function of laser intensity for a sodium magneto optical trap. Due to technical
limitation we explored only the low light intensity regime, from 0 to 27
mW/cm^2. Now we complement that work measuring the capture velocity in a
broader range of light intensities (from 0 to 400 mW/cm^2). New features,
observed in this range, are important to understant the escape velocity
behavior, which has been intensively used in the interpretation of cold
collisions. In particular, we show in this brief report that the capture
velocity has a maximum as function of the trap laser intensity, which would
imply a minimum in the trap loss rates.Comment: 2 pages, 2 figure
Worry as a window into the lives of people who use injection drugs: a factor analysis approach
<p>Abstract</p> <p>Background</p> <p>The concept of risk dominates the HIV/AIDS literature pertaining to People Who Use Injection Drugs (PWUID). In contrast the associated concept of worry is infrequently applied, even though it can produce important perspectives of PWUID's lives. This study asked a sample (n = 105) of PWUID enrolled in a Victoria, British Columbia needle exchange program to evaluate their degree of worry about fourteen factors they may encounter in their daily lives.</p> <p>Methods</p> <p>Exploratory factor analysis was used to analyze their responses.</p> <p>Results</p> <p>Factor analysis delineated three factors: 1) overall personal security, 2) injection drug use-specific risks including overdosing and vein collapse and, 3) contracting infectious diseases associated with injection drug use (e.g. HIV/AIDS and hepatitis C).</p> <p>Conclusion</p> <p>PWUID in this study not only worry about HIV/AIDS but also about stressful factors in their daily life which have been linked to both increased HIV/AIDS risk behaviour and decreased anti-retroviral treatment adherence. The importance PWUID give to this broad range of worry/concerns emphasizes the need to place HIV/AIDS intervention, education, and treatment programs within a broader harm-reduction framework that incorporates their perspectives on both worry and risk.</p
Evolution of Protoneutron Stars
We study the thermal and chemical evolution during the Kelvin-Helmholtz phase
of the birth of a neutron star, employing neutrino opacities that are
consistently calculated with the underlying equation of state (EOS).
Expressions for the diffusion coefficients appropriate for general relativistic
neutrino transport in the equilibrium diffusion approximation are derived. The
diffusion coefficients are evaluated using a field-theoretical finite
temperature EOS that includes the possible presence of hyperons. The variation
of the diffusion coefficients is studied as a function of EOS and compositional
parameters. We present results from numerical simulations of protoneutron star
cooling for internal stellar properties as well as emitted neutrino energies
and luminosities. We discuss the influence of the initial stellar model, the
total mass, the underlying EOS, and the addition of hyperons on the evolution
of the protoneutron star and upon the expected signal in terrestrial detectors.Comment: 67 pages, 25 figure
Combining DNP NMR with segmental and specific labeling to study a yeast prion protein strain that is not parallel in-register
The yeast prion protein Sup35NM is a self-propagating amyloid. Despite intense study, there is no consensus on the organization of monomers within Sup35NM fibrils. Some studies point to a â-helical arrangement, whereas others suggest a parallel inregister organization. Intermolecular contacts are often determined by experiments that probe long-range heteronuclear contacts for fibrils templated from a 1:1 mixture of 13 C- and 15 N-labeled monomers. However, for Sup35NM, like many large proteins, chemical shift degeneracy limits the usefulness of this approach. Segmental and specific isotopic labeling reduce degeneracy, but experiments to measure long-range interactions are often too insensitive. To limit degeneracy and increase experimental sensitivity, we combined specific and segmental isotopic labeling schemes with dynamic nuclear polarization (DNP) NMR. Using this combination, we examined an amyloid form of Sup35NM that does not have a parallel in-register structure. The combination of a small number of specific labels with DNP NMR enables determination of architectural information about polymeric protein systems. Keyword: [PSI+] prion; solid-state NMR; amyloid; Sup35; dynamic nuclear polarizationNational Institutes of Health (U.S.) (Grants GM-025874)National Institutes of Health (U.S.) (Grants EB-003151)National Institutes of Health (U.S.) (Grants EB-002804)National Institutes of Health (U.S.) (Grants EB-002026
Thermodynamics of Heat Shock Response
Production of heat shock proteins are induced when a living cell is exposed
to a rise in temperature. The heat shock response of protein DnaK synthesis in
E.coli for temperature shifts from temperature T to T plus 7 degrees,
respectively to T minus 7 degrees is measured as function of the initial
temperature T. We observe a reversed heat shock at low T. The magnitude of the
shock increases when one increase the distance to the temperature , thereby mimicking the non monotous stability of proteins at low
temperature. Further we found that the variation of the heat shock with T
quantitatively follows the thermodynamic stability of proteins with
temperature. This suggest that stability related to hot as well as cold
unfolding of proteins is directly implemented in the biological control of
protein folding. We demonstrate that such an implementation is possible in a
minimalistic chemical network.Comment: To be published in Physical Review Letter
Inference with interference between units in an fMRI experiment of motor inhibition
An experimental unit is an opportunity to randomly apply or withhold a
treatment. There is interference between units if the application of the
treatment to one unit may also affect other units. In cognitive neuroscience, a
common form of experiment presents a sequence of stimuli or requests for
cognitive activity at random to each experimental subject and measures
biological aspects of brain activity that follow these requests. Each subject
is then many experimental units, and interference between units within an
experimental subject is likely, in part because the stimuli follow one another
quickly and in part because human subjects learn or become experienced or
primed or bored as the experiment proceeds. We use a recent fMRI experiment
concerned with the inhibition of motor activity to illustrate and further
develop recently proposed methodology for inference in the presence of
interference. A simulation evaluates the power of competing procedures.Comment: Published by Journal of the American Statistical Association at
http://www.tandfonline.com/doi/full/10.1080/01621459.2012.655954 . R package
cin (Causal Inference for Neuroscience) implementing the proposed method is
freely available on CRAN at https://CRAN.R-project.org/package=ci
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