Pair Production of Charged Higgs Bosons from Bottom-Quark Fusion

For very large values of $\tan\beta$, charged Higgs boson pair production at the Large Hadron Collider (LHC) from the scattering of two bottom quarks can proceed dominantly. We investigated the cross sections of charged Higgs boson pair production via the subprocess $b\bar{b} \to H^+H^-$ at the LHC including the next-to-leading order (NLO) QCD corrections in the minimal supersymmetric standard model (MSSM). We find that the NLO QCD corrections can significantly reduce the dependence of the cross sections on the renormalization and factorization scales.Comment: small changes are mad

Onset of efficacy with acute long-acting injectable paliperidone palmitate treatment in markedly to severely ill patients with schizophrenia: post hoc analysis of a randomized, double-blind clinical trial

<p>Abstract</p> <p>Background</p> <p>This post hoc analysis (trial registration: ClinicalTrials.gov NCT00590577) assessed onset of efficacy and tolerability of acute treatment with once-monthly paliperidone palmitate (PP), a long-acting atypical antipsychotic initiated by day 1 and day 8 injections, in a markedly to severely ill schizophrenia population.</p> <p>Methods</p> <p>Subjects entering the 13-week, double-blind trial were randomized to PP (39, 156, or 234 mg [25, 100, and 150 mg eq of paliperidone, respectively]) or placebo. This subgroup analysis included those with a baseline Clinical Global Impressions-Severity (CGI-S) score indicating marked to severe illness. PP subjects received a 234-mg day 1 injection (deltoid), followed by their assigned dose on day 8 and monthly thereafter (deltoid or gluteal). Thus, data for PP groups were pooled for days 4 and 8. Measures included Positive and Negative Syndrome Scale (PANSS), CGI-S, Personal and Social Performance (PSP), and adverse events (AEs). Analysis of covariance (ANCOVA) and last-observation-carried-forward (LOCF) methodologies, without multiplicity adjustments, were used to assess changes in continuous measures. Onset of efficacy was defined as the first time point a treatment group showed significant PANSS improvement (assessed days 4, 8, 22, 36, 64, and 92) versus placebo, which was maintained through end point.</p> <p>Results</p> <p>A total of 312 subjects met inclusion criterion for this subgroup analysis. After the day 1 injection, mean PANSS total scores improved significantly with PP (all received 234 mg) versus placebo at day 4 (<it>P </it>= 0.012) and day 8 (<it>P </it>= 0.007). After the day 8 injection, a significant PANSS improvement persisted at all subsequent time points in the 234-mg group versus placebo (<it>P </it>< 0.05). PANSS improvements were greater from day 36 through end point in the 156-mg group (<it>P </it>< 0.05) and only at end point in the 39-mg group (<it>P </it>< 0.05). CGI-S and PSP scores improved significantly in the 234-mg and 156-mg PP groups versus placebo at end point (<it>P </it>< 0.05 for both, respectively); improvement in the 39-mg group was not significant. The most common AEs for PP-treated subjects (≥10%, any treatment group) were headache, insomnia, schizophrenia exacerbation, injection site pain, and agitation.</p> <p>Conclusions</p> <p>In this markedly to severely ill population, acute treatment with 234 mg PP improved psychotic symptoms compared with placebo by day 4. After subsequent injections, observed improvements are suggestive of a dose-dependent effect. No unexpected tolerability findings were noted.</p

Resonant Tunneling Between Quantum Hall Edge States

Resonant tunneling between fractional quantum Hall edge states is studied in the Luttinger liquid picture. For the Laughlin parent states, the resonance line shape is a universal function whose width scales to zero at zero temperature. Extensive quantum Monte Carlo simulations are presented for $\nu = 1/3$ which confirm this picture and provide a parameter-free prediction for the line shape.Comment: 14 pages , revtex , IUCM93-00

Preferential down-regulation of phospholipase C- β in Ewing's sarcoma cells transfected with antisense EWS-Fli-1

EWS-Fli-1, a fusion gene found in Ewing's sarcoma and primitive neuro-ectodermal tumour (PNET), encodes a transcriptional activator and promotes cellular transformation. We have made stable Ewing's sarcoma cells expressing antisense EWS-Fli-1 transcripts by transfecting the antisense EWS-Fli-1 expression plasmid. These cells showed partial loss of endogenous EWS-Fli-1 proteins and suppression of the cell growth. To elucidate the molecular mechanisms underlying the growth inhibition, we examined the changes of signal transducing proteins by immunoblot analysis in Ewing's sarcoma cells stably expressing antisense EWS-Fli-1 transcripts. Western blotting of the cell proteins revealed that expressions of phospholipase Cβ2 and β3 (PLCβ2, PLCβ3), and also protein kinase C α and β (PKCα, β) were significantly reduced by transfecting with antisense EWS-Fli-1. The inositol phosphates production by bradykinin (BK), but not platelet-derived growth factor (PDGF), was suppressed in these cells. These results suggest that the PLCβ2 and PLCβ3 may play a role in tumour proliferation in Ewing's sarcoma cells. © 2000 Cancer Research Campaig

Intercellular calcium signaling in a gap junction-coupled cell network establishes asymmetric neuronal fates in C. elegans

The C. elegans left and right AWC olfactory neurons specify asymmetric subtypes, one default AWC(OFF) and one induced AWC(ON), through a stochastic, coordinated cell signaling event. Intercellular communication between AWCs and non-AWC neurons via a NSY-5 gap junction network coordinates AWC asymmetry. However, the nature of intercellular signaling across the network and how individual non-AWC cells in the network influence AWC asymmetry is not known. Here, we demonstrate that intercellular calcium signaling through the NSY-5 gap junction neural network coordinates a precise 1AWC(ON)/1AWC(OFF) decision. We show that NSY-5 gap junctions in C. elegans cells mediate small molecule passage. We expressed vertebrate calcium-buffer proteins in groups of cells in the network to reduce intracellular calcium levels, thereby disrupting intercellular communication. We find that calcium in non-AWC cells of the network promotes the AWC(ON) fate, in contrast to the autonomous role of calcium in AWCs to promote the AWC(OFF) fate. In addition, calcium in specific non-AWCs promotes AWC(ON) side biases through NSY-5 gap junctions. Our results suggest a novel model in which calcium has dual roles within the NSY-5 network: autonomously promoting AWC(OFF) and non-autonomously promoting AWC(ON)

Suppression of self-discharge in a non-flowing bromine battery via <i>in situ </i>generation of countercharged groups

Bromine is attractive for next-generation energy-storage systems because of its high capacity and natural abundance. However, because of issues relating to self-discharging processes, prototypes involving bromide/bromine redox couples are largely limited to the design of flow cells. Here we propose a method to exploit bromine redox chemistry and demonstrate the feasibility of mitigating ion depletion in a stationary device. A cell using polyaniline vapor-grown carbon fiber (PANI-VGCF) as the electrode material exhibits close to 100% Coulombic efficiency at a low current density (50 mA/g). Electrochemical results, operando Raman spectroscopy, and theoretical analysis provide clues that the strong interaction between protonated PANI and Br−/ Br3− makes their decoupling unfavorable, thereby suppressing self-discharge processes. This strategy could be utilized for rational design of other conjugated materials/bromine systems without self-discharge issues

Flavor changing effects on single charged Higgs boson production associated with a bottom-charm pair at CERN Large Hadron Collider

We study flavor changing effects on the \ppbchT process at the Large Hadron Collider(LHC), which are inspired by the left-handed up-type squark mixings in the Minimal Supersymmetric Standard Model(MSSM). We find that the SUSY QCD radiative corrections to $bcH^\pm$ coupling can significantly enhance the cross sections at the tree-level by a factor about $1.5 \sim 5$ with our choice of parameters. We conclude that the squark mixing mechanism in the MSSM makes the \ppbchT process a new channel for discovering a charged Higgs boson and investigating flavor changing effects.Comment: One Latex file, 27 pages, 8 figures,to be appeared in PR

Coordination complexes as molecular glue for immobilization of antibodies on cyclic olefin copolymer surfaces

A novel metal-based chelating method has been used to provide an order of magnitude increase in immunoassay performance on cyclic olefin copolymer (COC) plastics compared with passive binding. COCs are hydrophobic, and without surface modification they are often unsuitable for applications where protein adhesion is desired. When interacting with the bare plastic, the majority of the bound proteins will be denatured and become nonfunctional. Many of the surface modification techniques reported to date require costly equipment setup or the use of harsh reaction conditions. Here, we have successfully demonstrated the use of a simple and quick metal chelation method to increase the sensitivity, activity, and efficiency of protein binding to COC surfaces. A detailed analysis of the COC surfaces after activation with the metal complexes is presented, and the immunoassay performance was studied using three different antibody pairs

Pair Production of the Lightest Chargino via Gluon-Gluon Collisions

The production of the lightest chargino pair from gluon-gluon fusion is studied in the minimal supersymmetric model(MSSM) at proton-proton colliders. We find that with the chosen parameters, the production rate of the subprocess can be over 2.7 femto barn when the chargino is higgsino-like, and the corresponding total cross section in proton-proton collider can reach 56 femto barn at the LHC in the CP-conserving MSSM. It shows that this loop mediated subprocess can be competitive with the standard Drell-Yan subprocess in proton-proton colliders, especially at the LHC. Furthermore, our calculation shows it would be possible to extract information about some CP-violating phase parameters, if we collected enough chargino pair events.Comment: 39 pages, LaTex, 8 figure