Nonequilibrium Zaklan model on Apollonian Networks

The Zaklan model had been proposed and studied recently using the equilibrium Ising model on Square Lattices (SL) by Zaklan et al (2008), near the critica temperature of the Ising model presenting a well-defined phase transition; but on normal and modified Apollonian networks (ANs), Andrade et al. (2005, 2009) studied the equilibrium Ising model. They showed the equilibrium Ising model not to present on ANs a phase transition of the type for the 2D Ising model. Here, using agent-based Monte-Carlo simulations, we study the Zaklan model with the well-known majority-vote model (MVM) with noise and apply it to tax evasion on ANs, to show that differently from the Ising model the MVM on ANs presents a well defined phase transition. To control the tax evasion in the economics model proposed by Zaklan et al, MVM is applied in the neighborhood of the critical noise $q_{c}$ to the Zaklan model. Here we show that the Zaklan model is robust because this can be studied besides using equilibrium dynamics of Ising model also through the nonequilibrium MVM and on various topologies giving the same behavior regardless of dynamic or topology used here.Comment: 11 pages, 6 figures. arXiv admin note: substantial text overlap with arXiv:1204.0386 and arXiv:0910.196

Prognostic value of alveolar volume in systolic heart failure: a prospective observational study

Ventilatory impairment is known to occur in patients with heart failure (HF). Alveolar volume (VA) is measured by the dilution of an inert gas during a single breath-hold maneuver. Such measurement is sensitive to ventilatory disturbances. We conducted a prospective, observational study to establish the prognostic value of VA in systolic HF

Histologic Classification and Molecular Signature of Polymorphous Adenocarcinoma (PAC) and Cribriform Adenocarcinoma of Salivary Gland (CASG) An International Interobserver Study

Polymorphous adenocarcinoma (PAC) shows histologic diversity with streaming and targetoid features whereas cribriform adenocarcinoma of salivary gland (CASG) demonstrates predominantly cribriform and solid patterns with glomeruloid structures and optically clear nuclei. Opinions diverge on whether CASG represents a separate entity or a variant of PAC. We aimed to assess the level of agreement among 25 expert Head and Neck pathologists in classifying these tumors. Digital slides of 48 cases were reviewed and classified as: PAC, CASG, tumors with >= 50% of papillary architecture (PAP), and tumors with indeterminate features (IND). The consensus diagnoses were correlated with a previously reported molecular alteration. The consensus diagnoses were PAC in 18/48, CASG in16/48, PAP in 3/48, and IND in 11/48. There was a fair interobserver agreement in classifying the tumors (kappa=0.370). The full consensus was achieved in 3 (6%) cases, all of which were classified as PAC. A moderate agreement was reached for PAC (kappa=0.504) and PAP (kappa=0.561), and a fair agreement was reached for CASG (kappa=0.390). IND had only slight diagnostic concordance (kappa=0.091). PAC predominantly harbored PRKD1 hotspot mutation, whereas CASG was associated with fusion involving PRKD1, PRKD2, or PRKD3. However, such molecular events were not exclusive as 7% of PAC had fusion and 13% of CASG had mutation. In conclusion, a fair to moderate interobserver agreement can be achieved in classifying PAC and CASG. However, a subset (23%) showed indeterminate features and was difficult to place along the morphologic spectrum of PAC/CASG among expert pathologists. This may explain the controversy in classifying these tumors