Ethical dimension of management of human activity and of human work results

The contemporary human being realizes that their activity influences the surrounding world and themselves. At the same time, the occurrences that have taken place in the 20th and 21st century make them recognize the fact of the existence of the multidimensional cultural crisis and that they have reached the “turning point.” These happenings inspire to reflection on the creative activity of the human being; they make us realize that it is really important, in relation to that activity, to exercise the virtue of wisdom, i.e. the constant predisposition to create the good. When you are citing the document, use the following link http://essuir.sumdu.edu.ua/handle/123456789/3430

Bounds on R-parity Violation from Resonant Slepton Production at the LHC

We consider the ATLAS and CMS searches for dijet resonances, as well as the ATLAS search for like-sign dimuon pairs at the LHC with 7 TeV center of mass energy. We interpret their exclusions in terms of bounds on the supersymmetric R-parity violating parameter space. For this we focus on resonant slepton production followed by the corresponding decay.Comment: 17 pages, 11 figures, 3 table

Resurrecting light stops after the 125 GeV Higgs in the baryon number violating CMSSM

In order to accommodate the observed Higgs boson mass in the CMSSM, the stops must either be very heavy or the mixing in the stop sector must be very large. Lower stop masses, possibly more accessible at the LHC, still give the correct Higgs mass only if the trilinear stop mixing parameter $|A_t|$ is in the multi-TeV range. Recently it has been shown that such large stop mixing leads to an unstable electroweak vacuum which spontaneously breaks charge or colour. In this work we therefore go beyond the CMSSM and investigate the effects of including baryon number violating operators $\lambda'' \bar{\bf U} \bar{\bf D}\bar{\bf D}$ on the stop and Higgs sectors. We find that for $\lambda'' \simeq {\mathcal{O}}(0.3)$ light stop masses as low as 220 GeV are consistent with the observed Higgs mass as well as flavour constraints while allowing for a stable vacuum. The light stop in this scenario is often the lightest supersymmetric particle. We furthermore discuss the importance of the one-loop corrections involving R-parity violating couplings for a valid prediction of the light stop masses.Comment: 26 pages, 9 figures; v2: slightly extended discussion about bounds from flavour observables; matches published versio

Evaluation of bioactivity of fucoidan from laminaria with in vitro human cell cultures (THP-1)

To access publisher's full text version of this article, please click on the hyperlink in Additional Links field or click on the hyperlink at the top of the page marked FilesBackground: Seaweeds represent one of the few remaining food sources available globally which are not being fully utilized or even over utilized. Kelps (Laminaria spp.) are one of the numerous species of brown seaweeds, a popular marine vegetable, which has been used as a source of iodine and minerals for centuries. Kelps contain anionic polysaccharides called fucoidans heteroglycans with L-fucose units. Their monosaccharide composition, physicochemical and bioactive properties vary between seaweed species. The objective of this work was to evaluate the bioactive properties of laminaria fucoidan (L. digitata and L. hyperborea) toward THP-1 macrophages, a human macrophage like cell line, and investigate its potential antioxidant and immunomodulatory characteristics. Methods: THP-1 macrophages were incubated with five fucoidan concentrations. The Oxygen Radical Absorbance Capacity (ORAC) assay was determined for cell lysates and for the fucoidan extract, in addition to Total Polyphenol Content (TPC). Cytotoxicity of fucoidan was assessed by light microscopy, followed by XTT proliferation assay. Enzyme-linked immunosorbant assays (ELISA) were performed to determine concentrations of the secreted tumor necrosis factor a (TNF-a), interleukin 6 (IL-6), and interleukin 10 (IL-10). Results: Fucoidan did not affect macrophage ability to scavenge oxygen radicals (ORAC) confirming its antioxidant properties toward activated macrophages. The laminaria fucoidan extract at 100 mu g/ml concentration lowered macrophage viability. Lower concentrations of laminaria fucoidan did not have impact on cell viability. Very low concentration of fucoidan at 0.1 mu g/ml triggered secretion of TNF-alpha. However, IL-6 and interleukin IL-10 were expressed when concentration of applied fucoidan was 10 mu g/ml indicating bioactivity of laminaria fucoidan through immunomodulatory actions. Conclusions: The study demonstrated how laminaria fucoidan may have bioactive properties towards THP-1 macrophages. Changes in cytokine secretion between pro-inflammatory (TNF-alpha, and IL-6) and anti-inflammatory (IL-10) cytokines confirmed bioactivity of the laminaria fucoidan extracts.University of Iceland Research Fun

The Role of Dysregulated miRNAs in the Pathogenesis, Diagnosis and Treatment of Age-Related Macular Degeneration

Age-related macular degeneration (AMD) is an eye disease causing damage to the macular region of the retina where most of the photoreceptors responsible for central visual acuity are located. MicroRNAs (miRNAs) are small single-stranded non-coding RNA molecules that negatively regulate genes by silent post-transcriptional gene expressions. Previous studies have shown that changes in specific miRNAs are involved in the pathogenesis of eye diseases, including AMD. Altered expressions of miRNAs are related to disturbances of regulating oxidative stress, inflammation, angiogenesis, apoptosis and phagocytosis, which are known factors in the pathogenesis of AMD. Moreover, dysregulation of miRNA is involved in drusen formation. Thus, miRNAs may be used as potential molecular biomarkers for the disease and, furthermore, tailoring therapeutics to particular disturbances in miRNAs may, in the future, offer hope to prevent irreversible vision loss. In this review, we clarify the current state of knowledge about the influence of miRNA on the pathogenesis, diagnosis and treatment of AMD. Our study material consisted of publications, which were found in PubMed, Google Scholar and Embase databases using "Age-related macular degeneration", "miRNA", "AMD biomarkers", "miRNA therapeutics" and "AMD pathogenesis" as keywords. Paper search was limited to articles published from 2011 to date. In the section "Retinal, circulating and vitreous body miRNAs found in human studies", we limited the search to studies with patients published in 2016-2021

Discovery Potential of Selectron or Smuon as the Lightest Supersymmetric Particle at the LHC

We investigate the LHC discovery potential of R-parity violating supersymmetric models with a right-handed selectron or smuon as the lightest supersymmetric particle (LSP). These LSPs arise naturally in R-parity violating minimal supergravity models. We classify the hadron collider signatures and perform for the first time within these models a detailed signal over background analysis. We develop an inclusive three-lepton search and give prospects for a discovery at a center-of-mass energy of 7 TeV as well as 14 TeV. There are extensive parameter regions which the LHC can already test with 7 TeV and an integrated luminosity of 1 inverse femtobarn. We also propose a method for the mass reconstruction of the supersymmetric particles within our models at 14 TeV.Comment: 33 pages, 24 figures; preprint number added, layout correcte