Liquid phase immunoassay utilizing magnetic marker and high Tc superconducting quantum interference device

We have developed a liquid phase immunoassay system utilizing a magnetic marker and a superconducting quantum interference device (SQUID). In this system, the magnetic marker was used to detect the biological material called antigen. The magnetic marker was designed so as to generate a remanence, and the remanence field of the markers that bound to the antigens was measured with the SQUID. The measurement was performed in a solution that contained both the bound and free (or unbound) markers, i.e., without using the so-called bound/free (BF) separation process. The Brownian rotation of the free markers in the solution was used to distinguish the bound markers from the free ones. Using the system, we conducted the detection of biological material called IgE without BF separation. At present, we could detect the IgE down to 7 pg (or 39 amol

Higher Hall conductivity from a single wave function: Obstructions to symmetry-preserving gapped edge of (2+1)D topological order

A (2+1)D topological ordered phase with U(1) symmetry may or may not have a symmetric gapped edge state, even if both thermal and electric Hall conductivity are vanishing. It is recently discovered that there are "higher" versions of Hall conductivity valid for fermionic fractional quantum Hall (FQH) states, which obstructs symmetry-preserving gapped edge state beyond thermal and electric Hall conductivity. In this paper, we show that one can extract higher Hall conductivity from a single wave function of an FQH state, by evaluating the expectation value of the "partial rotation" unitary which is a combination of partial spatial rotation and a U(1) phase rotation. This result is verified numerically with the fermionic Laughlin state with $\nu=1/3$, $1/5$, as well as the non-Abelian Moore-Read state. Together with topological entanglement entropy, we prove that the expectation values of the partial rotation completely determines if a bosonic/fermionic Abelian topological order with U(1) symmetry has a symmetry-preserving gappable edge state or not. We also show that thermal and electric Hall conductivity of Abelian topological order can be extracted by partial rotations. Even in non-Abelian FQH states, partial rotation provides the Lieb-Schultz-Mattis type theorem constraining the low-energy spectrum of the bulk-boundary system. The generalization of higher Hall conductivity to the case with Lie group symmetry is also presented.Comment: 17 pages, 4 figures, minor edit

Extracting higher central charge from a single wave function

A (2+1)D topologically ordered phase may or may not have a gappable edge, even if its chiral central charge $c_-$ is vanishing. Recently, it is discovered that a quantity regarded as a ``higher'' version of chiral central charge gives a further obstruction beyond $c_-$ to gapping out the edge. In this Letter, we show that the higher central charges can be characterized by the expectation value of the \textit{partial rotation} operator acting on the wavefunction of the topologically ordered state. This allows us to extract the higher central charge from a single wavefunction, which can be evaluated on a quantum computer. Our characterization of the higher central charge is analytically derived from the modular properties of edge conformal field theory, as well as the numerical results with the $\nu=1/2$ bosonic Laughlin state and the non-Abelian gapped phase of the Kitaev honeycomb model, which corresponds to $\mathrm{U}(1)_2$ and Ising topological order respectively. The letter establishes a numerical method to obtain a set of obstructions to the gappable edge of (2+1)D bosonic topological order beyond $c_-$. We also point out that the expectation values of the partial rotation on a single wavefunction put a constraint on the low-energy spectrum of the bulk-boundary system of (2+1)D bosonic topological order, reminiscent of the Lieb-Schultz-Mattis type theorems.Comment: 16 pages, 12 figure

Universal tripartite entanglement in one-dimensional many-body systems

Motivated by conjectures in holography relating the entanglement of purification and reflected entropy to the entanglement wedge cross-section, we introduce two related non-negative measures of tripartite entanglement $g$ and $h$. We prove structure theorems which show that states with nonzero $g$ or $h$ have nontrivial tripartite entanglement. We then establish that in 1D these tripartite entanglement measures are universal quantities that depend only on the emergent low-energy theory. For a gapped system, we argue that either $g\neq 0$ and $h=0$ or $g=h=0$, depending on whether the ground state has long-range order. For a critical system, we develop a numerical algorithm for computing $g$ and $h$ from a lattice model. We compute $g$ and $h$ for various CFTs and show that $h$ depends only on the central charge whereas $g$ depends on the whole operator content.Comment: 5+16 pages, 4+5 figure