Emission spectrum of hot HDO below 4000 cm-1

Fourier transform emission spectra were recorded using a mixture of H2O and D2O at a temperature of 1500 °C. The spectra were recorded in three overlapping sections and cover the wavenumber range 1800–3932 cm−1. This spectrum is analyzed together with a previously reported one spanning the 380–2190 cm−1 range [Parekunnel et al., J. Mol. Spectrosc. 2001 (28) 101]. This analysis leads to 4409 newly assigned HDO emission lines. This work particularly extends data on the (200) and (120) states of HDO for which newly determined energy levels are presented

Three consecutive pregnancies having arthrogryposis multiplex congenita

Arthrogryposis Multiplex Congenita is a syndrome or disorder that presents with multiple congenital joint contractures at birth. It is X-linked recessive disorder, non-progressive and is of variable severity. Here is a case report with three consecutive pregnancies having fetus affected with Arthrogryposis Multiplex Congenita (AMC) diagnosed antenatally. Arthrogryposis Multiplex Congenita affects 1 in 3000 live births. During embryogenesis, joint development is normal. Motion is essential for the normal development of joints and surrounding structures. Fetal akinesia causes extra connective tissue to develop around the joint. This results in fixation of the joint and a further increase in the contracture. Earlier in pregnancy the contractures form, worse is the prognosis

Sesquicarbene Complexes:Bonding at the Interface Between M-C Single Bonds and M=C Double Bonds

Allylic dimetalated complexes [M2C(vinyl)]+ (M = Au(IPr) and Cr(CO)5 -) incorporate a new coordination mode of carbon. Digold complexes of this type have recently been detected experimentally. The intrinsic bond orbitals, partial charges, and structural parameters of the gold complexes and of chromium analogs were studied computationally and compared to those of the respective monometalated species and hydrocarbons. This showed that such digold complexes have a carbene character at both Au-C bonds comparable to typical carbene complexes of gold. Dichromium complexes with their stronger π-backdonation compete for interaction with carbon's π-orbital; each of the chromium atoms partakes in double bonding that is significant but weaker than that in the carbene analogs. Containing two M-C bonds on the interface between single and double bonds, these bridged complexes can be conceived as "sesquicarbene complexes". The π-system acted in a very adaptive manner and employed additional stabilization of the vinyl system only where needed. Significant carbene character is found simultaneously in both M-C bonds at the same carbon center. The discovery of these complexes with relatively strong double bond character between one carbon and two metal atoms could bring unusual single-carbon-centered organometallic cascade reactions to the horizon

Diaqua­dichloridobis[quinazolin-4(1H)-one-κN 3]nickel(II)

In the title complex, [NiCl2(C8H6N2O)2(H2O)2], the NiII ion is located on an inversion center and is six-coordinated by two N atoms of 1H-quinazolin-4-one ligands, two chloride ions and two water mol­ecules. The water mol­ecules are involved in intra- and inter­molecular O—H⋯O and O—H⋯Cl hydrogen bonding. Inter­molecular N—H⋯O and N—H⋯Cl hydrogen bonds are formed between ligands. In addition, weak π–π inter­actions are observed between the benzene rings of the ligands [centroid–centroid distance = 3.580 (3) Å]. The inter­molecular hydrogen bonds and π–π inter­actions lead to the formation of a three-dimensional supra­molecular network

Srs2 promotes synthesis-dependent strand annealing by disrupting DNA polymerase δ-extending D-loops.

Synthesis-dependent strand annealing (SDSA) is the preferred mode of homologous recombination in somatic cells leading to an obligatory non-crossover outcome, thus avoiding the potential for chromosomal rearrangements and loss of heterozygosity. Genetic analysis identified the Srs2 helicase as a prime candidate to promote SDSA. Here, we demonstrate that Srs2 disrupts D-loops in an ATP-dependent fashion and with a distinct polarity. Specifically, we partly reconstitute the SDSA pathway using Rad51, Rad54, RPA, RFC, DNA Polymerase δ with different forms of PCNA. Consistent with genetic data showing the requirement for SUMO and PCNA binding for the SDSA role of Srs2, Srs2 displays a slight but significant preference to disrupt extending D-loops over unextended D-loops when SUMOylated PCNA is present, compared to unmodified PCNA or monoubiquitinated PCNA. Our data establish a biochemical mechanism for the role of Srs2 in crossover suppression by promoting SDSA through disruption of extended D-loops

Symmetries and Cluster Synchronization in Multilayer Networks

Real-world systems in epidemiology, social sciences, power transportation, economics and engineering are often described as multilayer networks. Here we first define and compute the symmetries of multilayer networks, and then study the emergence of cluster synchronization in these networks. We distinguish between independent layer symmetries which occur in one layer and are independent of the other layers and dependent layer symmetries which involve nodes in different layers. We study stability of the cluster synchronous solution by decoupling the problem into a number of independent blocks and assessing stability of each block through a Master Stability Function. We see that blocks associated with dependent layer symmetries have a different structure than the other blocks, which affects the stability of clusters associated with these symmetries. Finally, we validate the theory in a fully analog experiment in which seven electronic oscillators of three kinds are connected with two kinds of coupling

Alemtuzumab induced ST-segment elevation and acute myocardial dysfunction

AbstractCardiac toxicity as a side effect of chemotherapeutic agents has been well reported in the literature. Cardiac toxicity secondary to alemtuzumab has been reported, presenting as congestive heart failure and arrhythmias. Here we report a case of acute myocardial dysfunction after administration of a test dose of alemtuzumab. Our patient was a 66-year-old man with a history of small lymphocytic lymphoma/chronic lymphocytic lymphoma who received a test dose of alemtuzumab. Twenty minutes post administration, the patient developed nausea, vomiting, rigors, and tachycardia. Electrocardiography (ECG) showed acute ST-segment elevations in contiguous leads V2–V6, I, and AVL with no associated chest pain. Bedside echocardiogram showed akinesis of the anterior septum, apex, distal anterior wall, and decreased left ventricular ejection fraction. Cardiac catheterization showed non-critical occlusive disease and no intervention was undertaken. Post-catheterization ECG revealed resolution of ST segment elevations, TWI in V4–V6, and prolongation of corrected QT. Repeat echocardiogram 10 days after the event demonstrated no improvement in wall motion or ejection fraction. We discuss the possible mechanisms causing ST-elevations and acute myocardial dysfunction after treatment with alemtuzumab.<Learning objective: Alemtuzumab can cause acute myocardial dysfunction after administration of a test dose. Considering that this is a serious adverse effect, detailed cardiac evaluation and a high level of caution are recommended before administration of alemtuzumab. While no clear etiology could be identified for this side effect, excessive and acute cytokine release triggered by alemtuzumab administration is a possible explanation. This could be potentially attenuated by using anti-interleukin-6 or tumor necrosis factor inhibitors.

In situ monitoring of cellulose etherification in solution: probing the impact of solvent composition on the synthesis of 3-allyloxy-2-hydroxypropyl-cellulose in aqueous hydroxide systems

Etherification of cellulose using allyl glycidyl ether was carried out in aqueous alkaline solutions of benzyltrimethylammonium hydroxide, tetramethylammonium hydroxide, NaOH and different mixtures of these bases in order to study the effect of hydroxide base composition on the course of the reaction and the resulting product properties. In situ FTIR spectroscopy and time sweep shear measurements were carried out to monitor the reactions in real time. Infrared Attenuated Total Reflectance Spectroscopy and H-1 NMR confirmed the synthesis of 3-allyloxy-2-hydroxypropyl-cellulose and 2D HSQC NMR confirmed substitution on C2, C3 and C6 in all of the solvents. Quantitative C-13 NMR was used to estimate the molar substitution. Cellulose solutions in these quaternary ammonium hydroxides showed higher stability at 50 degrees C during the course of reaction, faster dissolution and hydrolysis of allyl glycidyl ether and lower molar substitution values compared to NaOH. Even though the highest molar substitution value was obtained in NaOH, the isolated product from this medium had lower solubility in DMSO-d(6) and its C-13 NMR did not differ significantly except for higher intensity of C1 and C6 compared to the other spectra. The obtained results indicated a more pronounced cascade reaction on the substitution itself in NaOH and lower temperature stability of cellulose solutions in this solvent

Laboratory spectroscopy of hot water near 2-microns and sunspot spectroscopy in the H-band region

The infrared spectrum of sunspots is analyzed in the H-band region (55406997 cm-1) with the aid of a new, hot (T = 1800 K) laboratory emission spectrum of water covering 48787552 cm-1. There are 682 lines in the sunspot spectrum and 5589 lines in the laboratory spectrum assigned quantum numbers corresponding to transitions due to H216O using a combination of previously known experimental energy levels for water and variational line lists. A further 201 unassigned lines common to both spectra can also be associated with water