KDM2B/FBXL10 targets c-Fos for ubiquitylation and degradation in response to mitogenic stimulation.

KDM2B (also known as FBXL10) controls stem cell self-renewal, somatic cell reprogramming and senescence, and tumorigenesis. KDM2B contains multiple functional domains, including a JmjC domain that catalyzes H3K36 demethylation and a CxxC zinc-finger that recognizes CpG islands and recruits the polycomb repressive complex 1. Here, we report that KDM2B, via its F-box domain, functions as a subunit of the CUL1-RING ubiquitin ligase (CRL1/SCF(KDM2B)) complex. KDM2B targets c-Fos for polyubiquitylation and regulates c-Fos protein levels. Unlike the phosphorylation of other SCF (SKP1-CUL1-F-box)/CRL1 substrates that promotes substrates binding to F-box, epidermal growth factor (EGF)-induced c-Fos S374 phosphorylation dissociates c-Fos from KDM2B and stabilizes c-Fos protein. Non-phosphorylatable and phosphomimetic mutations at S374 result in c-Fos protein which cannot be induced by EGF or accumulates constitutively and lead to decreased or increased cell proliferation, respectively. Multiple tumor-derived KDM2B mutations impaired the function of KDM2B to target c-Fos degradation and to suppress cell proliferation. These results reveal a novel function of KDM2B in the negative regulation of cell proliferation by assembling an E3 ligase to targeting c-Fos protein degradation that is antagonized by mitogenic stimulations

Cross-Task Transfer for Geotagged Audiovisual Aerial Scene Recognition

Aerial scene recognition is a fundamental task in remote sensing and has recently received increased interest. While the visual information from overhead images with powerful models and efficient algorithms yields considerable performance on scene recognition, it still suffers from the variation of ground objects, lighting conditions etc. Inspired by the multi-channel perception theory in cognition science, in this paper, for improving the performance on the aerial scene recognition, we explore a novel audiovisual aerial scene recognition task using both images and sounds as input. Based on an observation that some specific sound events are more likely to be heard at a given geographic location, we propose to exploit the knowledge from the sound events to improve the performance on the aerial scene recognition. For this purpose, we have constructed a new dataset named AuDio Visual Aerial sceNe reCognition datasEt (ADVANCE). With the help of this dataset, we evaluate three proposed approaches for transferring the sound event knowledge to the aerial scene recognition task in a multimodal learning framework, and show the benefit of exploiting the audio information for the aerial scene recognition. The source code is publicly available for reproducibility purposes.Comment: ECCV 202

Pressure- and stress-induced fabric transition in olivine from peridotites in the Western Gneiss Region (Norway): implications for mantle seismic anisotropy (supporting files)

The effects of pressure, water and differential stress on the crystallographic preferred orientation (CPO) of olivine were investigated by an integrated study on 13 peridotite samples from four areas in the Western Gneiss Region (WGR) of the Norwegian Caledonides. The highly depleted dunites are mantle residues after Archean melt extraction, while the garnet peridotites were formed by refertilization of the dunites via melt percolation in the Proterozoic. These orogenic peridotites were tectonically emplaced into Proterozoic gneisses and metasedimentary rocks of the WGR and were recrystallized under high-pressure (HP) to ultrahigh-pressure (UHP) conditions when the Baltic Shield was subducted beneath Laurentia during the 420–400 Ma Scandian orogeny. The CPOs of olivine, enstatite and diopside were measured using the electron backscatter diffraction technique. The weakly deformed garnet wehrlites and dunites from the HP central WGR (the Gurskøy, Almklovdalen and Tafjord areas) show the A-type olivine fabric defined by the [100] axis subparallel to the stretching lineation and the (010) plane subparallel to the foliation, which may be a relict fabric formed at high temperature and low strain rate in the mantle wedge prior to subduction. The [001](010) fabric (B-type) is observed in strongly sheared HP garnet peridotites and dunites from the Almklovdalen and Tafjord areas, suggesting the dominant activation of [001](010) slip system at high stress and high strain rate. Recrystallized fine olivine grains may develop a fabric different from porphyroclasts and record a gradual fabric transition. The olivine CPO in garnet lherzolites from Otrøy in the northernmost WGR is characterized by the concentration of [001] axes parallel to the stretching lineation and [100] axes normal to the foliation, indicating a prevailing [001](100) slip (C-type fabric) at P–T conditions of <6 GPa and 850–950 °C. Despite very different deformation microstructures, Fourier transform infrared analysis reveals very low water contents (<13 ppm H2O by the Paterson calibration) in olivine for both coarse porphyroclasts and recrystallized small grains, which is consistent with the high-degree partial melting of the peridotites during the Archean. Therefore, a combination of UHP and low temperature plays a more important role than water in promoting the C-type olivine fabric in a dry, cold and deeply subducted continental slab. With increasing subduction depths, the C-type olivine fabric will predominate over the A-type fabric and make the maximum P-wave velocity and shear wave splitting of peridotites normal to the foliation. However, the stress-induced fabric transition in olivine from the A-type to the B-type may be localized in shear zones and not distinguishable in seismic anisotropy observations

Crop genetics research in Asia: improving food security and nutrition

Breakthroughs in genomics research in recent decades have fundamentally changed the landscape of crop science at a number of fronts: (1) High-quality reference genome sequences have become available for most of the crops which have provided the foundation for understanding the genome and for functional genomic studies. (2) Large numbers of genes have been identified and functionally characterized for many important agronomic traits, which have greatly enhanced the understanding of the regulatory mechanisms and the underlying biological processes for the making of the traits. (3) Large-scale resequencing of the diverse germplasms and genome-wide association studies (GWAS) have provided assessment about the extent of genome diversity, the genetic architecture, and association between the phenotype and DNA sequence polymorphisms in many crop species. (4) Systems of breeding technologies based on the advance in genomic studies, or genomic breeding, have now been developed including novel goals in response to the evolving demands of the consumers, upgraded definitions of traits to be improved, techniques for whole genome selection, and varietal designs for the implementation

Fractionation of Volatile Constituents from Curcuma Rhizome by Preparative Gas Chromatography

A preparative gas chromatography (pGC) method was developed for the separation of volatile components from the methanol extract of Curcuma rhizome. The compounds were separated on a stainless steel column packed with 10% OV-101 (3 m × 6 mm, i.d.), and then, the effluent was split into two gas flows. One percent of the effluent passed to the flame ionization detector (FID) for detection and the remaining 99% were directed to the fraction collector. Five volatile compounds were collected from the methanol extract of Curcuma rhizome (5 g/mL) after 83 single injections (20 uL) with the yield of 5.1–46.2 mg. Furthermore, the structures of the obtained compounds were identified as β-elemene, curzerene, curzerenone, curcumenol, and curcumenone by MS and NMR spectra, respectively

High H2O content in Pyroxenes of residual mantle Peridotites at a Mid Atlantic ridge segment

Global correlations of mid-ocean-ridges basalt chemistry, axial depth and crustal thickness have been ascribed to mantle temperature variations affecting degree of melting. However, mantle H2O content and elemental composition may also play a role. How H2O is distributed in the oceanic upper mantle remains poorly constrained. We tackled this problem by determining the H2O content of orthopyroxenes (opx) and clinopyroxenes (cpx) of peridotites from a continuous lithospheric section created during 26 Ma at a 11°N Mid-Atlantic Ridge segment, and exposed along the Vema Transform. The H2O content of opx ranges from 119 ppm to 383 ppm; that of cpx from 407 ppm to 1072 ppm. We found anomalous H2O-enriched peridotites with their H2O content not correlating inversely with their degree of melting, although H2O is assumed to be incompatible during melting. Inverse correlation of H2O with Ce, another highly incompatible component, suggests post-melting H2O enrichment. We attribute a major role to post-melting temperature-dependent diffusion of hydrogen occurring above the melting region, where water-rich melt flows faster than residual peridotites through dunitic conduits cross-cutting the uprising mantle. Accordingly, estimates of the H2O content of the MORB mantle source based on H2O in abyssal peridotites can be affected by strong uncertainties

Neurotrophic keratopathy due to dorsolateral medullary infarction (Wallenberg Syndrome): case report and literature review

Background: Dorsolateral medullary infarction (Wallenberg Syndrome) is rare in clinical practice; however, the subsequent corneal lesions are more uncommon. To our knowledge, only one such case was previously reported. We report a similar case with successful treatment and recovery, and analyse both cases to address the clinical features and outcomes of such syndrome. / Case presentation: A 43-year-old male presented with neurotrophic keratopathy one month after sustaining dorsolateral medullary infarction. The patient underwent amniotic membrane transplantation twice. Two-year follow-up observation revealed changes in nerve fibers and epithelial cells of corneal by laser confocal microscopy. / Conclusion: By studying both cases, we confirm that neurotrophic keratopathy could be as a delayed-onset complication of Wallenberg syndrome. The recognition that neurotrophic keratopathy can follow dorsolateral medullary infarction could prevent the clinical misdiagnosis