8 research outputs found
Performance of mitochondrial DNA mutations detecting early stage cancer
- Author
- A Maitra
- A Salas
- Alissa K Greenberg
- Anirban Maitra
- AS Jun
- C Goessl
- C Goessl
- C Jeronimo
- Catherine D O'Connell
- D Meierhofer
- D Sidransky
- David Sidransky
- DC Wallace
- DC Wallace
- DC Wallace
- DG Murdock
- DJ Cutler
- E Ruiz-Pesini
- G Attardi
- G Sui
- GD Dakubo
- H Sharma
- HJ Bandelt
- J Feher
- J Maki
- JA Petros
- JB Jones
- JL Hess
- John P Jakupciak
- JP Jakupciak
- JP Jakupciak
- JP Jakupciak
- JS Penta
- JZ Chen
- K Hibi
- K Ishikawa
- K Polyak
- LC Wong
- LM Booker
- M Brandon
- M Sanchez-Cespedes
- M Suzuki
- M Verma
- Maura E Markowitz
- MO Hoque
- Mohammad O Hoque
- MS Fliss
- O Okochi
- P Parrella
- P Parrella
- Paul D Wagner
- Peter E Barker
- PF Chinnery
- PK Ha
- RL Parr
- RW Taylor
- S Maragh
- S Melov
- S Melov
- S Melov
- S Nomoto
- Samantha Maragh
- SL Prior
- SM Jazwinski
- Sudhir Srivastava
- SW Ballinger
- T Mizumachi
- W Zhu
- WC Copeland
- William N Rom
- WM Brown
- YG Yao
- Publication venue
- BioMed Central
- Publication date
- 01/01/2008
- Field of study
<p>Abstract</p> <p>Background</p> <p>Mutations in the mitochondrial genome (mtgenome) have been associated with cancer and many other disorders. These mutations can be point mutations or deletions, or admixtures (heteroplasmy). The detection of mtDNA mutations in body fluids using resequencing microarrays, which are more sensitive than other sequencing methods, could provide a strategy to measure mutation loads in remote anatomical sites.</p> <p>Methods</p> <p>We determined the mtDNA mutation load in the entire mitochondrial genome of 26 individuals with different early stage cancers (lung, bladder, kidney) and 12 heavy smokers without cancer. MtDNA was sequenced from three matched specimens (blood, tumor and body fluid) from each cancer patient and two matched specimens (blood and sputum) from smokers without cancer. The inherited wildtype sequence in the blood was compared to the sequences present in the tumor and body fluid, detected using the Affymetrix Genechip<sup>Âź </sup>Human Mitochondrial Resequencing Array 1.0 and supplemented by capillary sequencing for noncoding region.</p> <p>Results</p> <p>Using this high-throughput method, 75% of the tumors were found to contain mtDNA mutations, higher than in our previous studies, and 36% of the body fluids from these cancer patients contained mtDNA mutations. Most of the mutations detected were heteroplasmic. A statistically significantly higher heteroplasmy rate occurred in tumor specimens when compared to both body fluid of cancer patients and sputum of controls, and in patient blood compared to blood of controls. Only 2 of the 12 sputum specimens from heavy smokers without cancer (17%) contained mtDNA mutations. Although patient mutations were spread throughout the mtDNA genome in the lung, bladder and kidney series, a statistically significant elevation of tRNA and ND complex mutations was detected in tumors.</p> <p>Conclusion</p> <p>Our findings indicate comprehensive mtDNA resequencing can be a high-throughput tool for detecting mutations in clinical samples with potential applications for cancer detection, but it is unclear the biological relevance of these detected mitochondrial mutations. Whether the detection of tumor-specific mtDNA mutations in body fluidsy this method will be useful for diagnosis and monitoring applications requires further investigation.</p
Effect of silybin on high-fat-induced fatty liver in rats
- Author
- Ackerman Z
- Aller R
- Amarapurkar DN
- Anania FA
- Argo CK
- Begriche K
- Bonora E
- Briancon N
- Bugianesi E
- Chen Minhu
- Chen Qi
- Crocenzi FA
- de la Monte SM
- de Silva HJ
- Ekstedt M
- Feher J
- Harrison SA
- Hillenbrand A
- Jiayin Yao
- Kamada Y
- Kleiner DE
- Lian LH
- Loguercio C
- Lyles BE
- Macias-Rodriguez RU
- Mantena SK
- Mantena SK
- Marchesini G
- Min Zhi
- Mollica MP
- Patel N
- Perez-Carreras M
- Pessayre D
- Polyak SJ
- Rector RS
- Salman TA
- Sanyal AJ
- Serviddio G
- Serviddio G
- Silswal N
- Yki-Jarvinen H
- You M
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
Comparative nutritional and microbiological quality of ready to cook mixed vegetable curry
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Effect of processing parameters on physico-chemical and culinary quality of dried carrot slices
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Effects of Blanching on Some Physical Properties and Processing Recovery of Sweet Corn Cobs
- Author
- A Kramer
- AI Nelson
- AI Nelson
- AS Grandison
- ASAE
- C Arroqui
- CP Mallett
- D Reid
- DF Olivera
- DM Barrett
- DM Barrett
- DM Dignan
- DW Stanley
- E Feibert
- EO Afoakwa
- EZ Liu
- F Azanza
- GE Inglett
- I NiedziĂłĆka
- I NiedziĂłĆka
- JD Selman
- JD Selman
- K Lentas
- K Polyak-Feher
- K Trongpanich
- M Grzeszczuk
- M Togeby
- Mariusz Szymanek
- NN Mohsenin
- PS Chattopadhyay
- S Boyes
- S Mukherjee
- SG Rudra
- T Pukrushpan
- Y Chen
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Silymarin Ascending Multiple Oral Dosing Phase I Study in Noncirrhotic Patients With Chronic Hepatitis C
- Author
- Abdus S. Wahed
- Bonifaz
- Cornberg
- Edward Doo
- Eisenberg
- Feher
- Ferenci
- Ferenci
- Flaig
- Flora
- Fried
- Gharagozloo
- Gordon
- Han
- Hoofnagle
- Jia
- Josh Berman
- K. Rajender Reddy
- Kim
- Kim
- Kren
- Lang
- Lang
- Lucena
- Manna
- Manns
- Mayer
- Michael W. Fried
- Miranda
- Morazzoni
- Morazzoni
- Nezam H. Afdhal
- Par
- Pares
- Philip C. Smith
- Polyak
- Psotova
- Qi-Ying Liu
- Roy L. Hawke
- Salmi
- Sarah J. Schrieber
- Schandalik
- Schrieber
- Schumann
- Seeff
- Soule
- Steven H. Belle
- Strader
- Tanamly
- Tanasescu
- Tedi A. Soule
- Tsai
- Victor J. Navarro
- Wen
- Zhiming Wen
- Publication venue
- 'SAGE Publications'
- Publication date
- Field of study
The potential of silymarin for the treatment of hepatic disorders
- Author
- A Mahli
- A Rambaldi
- A Sasu
- A Weinmann
- AA Hagag
- AA Hajiaghamohammadi
- AA Mokdad
- AGT Ghosh
- AJ Engstler
- AM Gusdon
- AM Tormos
- APR Pares
- B Podder
- B Rehermann
- B Schnabl
- BA Moayedi Esfahani
- C Hoh
- C Hutchinson
- CC Li
- CL Basiglio
- D Bunout
- D Ezhilarasan
- D Konrad
- D Schuppan
- D Schuppan
- DF Wu
- DH Jeong
- DM Roberts
- E Ceni
- E Grabhorn
- E Seki
- ECDC
- EHSJ Hajiani
- EM Brunt
- F Machicao
- F Salamone
- F Salamone
- FR Mario Di
- G Muzes
- H Hayashi
- H Solhi
- HASS Salmi
- HH-TA Esmaily
- IAK Ei.Christodoulou
- IS Chen
- J Doehmer
- J Doehmer
- J Henao-Mejia
- J Wagoner
- J Ward
- J Xu
- J Zhao
- JC Lin
- JC Trinchet
- JDG Feher
- JGJ Luther
- JK Dunnick
- JK Dyson
- JM Schattenberg
- JM Schattenberg
- JS Bajaj
- JS Kang
- K Kock
- KD Ladas EJ
- KE Mayer
- KP Anthony
- KSG Tushar Kanti Maiti
- L Calani
- L Pellegrini
- L Scalone
- L Zhu
- LB Seeff
- LD Robb-Gaspers
- LM Kassem
- M Blachier
- M Demir
- M Kim
- M Rastegarpanah
- M Trappoliere
- MA Robin
- ME Shaker
- MI Lucena
- MR Charlton
- MRA Masoodi
- N Vargas-Mendoza
- NA Dunnick JK
- ND Freedman
- OM Abdel Salam
- P Ferenci
- P Ferenci
- P Pais
- R Bataller
- R Greek
- R Roberti
- R Saller
- R Vecera AZ
- RG Singh Gaaminepreet
- RJ Wong
- RL Hawke
- RL Waller
- S Bellentani
- S Clichici
- S Iwakami
- S Saab
- S Vladimir-Knezevic
- SF Schlosser
- SJ Brantley
- SJ Brantley
- SJ Polyak
- SJ Schrieber
- SJHE Hashemi
- SJMG Huilgol
- SK Asrani
- SK Mantena
- SMM Minicis De
- SR Miranda
- T Nichols Jr
- T Parasassi
- TW Flaig
- U Fuhr
- U Mengs
- V Bunel
- V Ratziu
- V Sharma
- WP Koh
- X Dai
- XH Chen
- Y Han
- Y Liu
- Z Bian
- Z Wen
- ZY Zheng
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
ViskositÀt
- Author
- A Artemcenko
- A Baader
- A Bak
- A Banchettr
- A Banchettr
- A Bartoli
- A Bartoli
- A Bearden
- A Bestelmeyer
- A Bestelmeyer
- A Bienas
- A Bienas
- A Bock de
- A Boek
- A Bramley
- A Broese Groeneu van
- A Camerton
- A Campetti
- A Crozier
- A Dietzel
- A Einstein
- A Einstein
- A Emmerich
- A Findlay
- A Fortier
- A Fortier
- A Gille
- A Gorke
- A Heydweiller
- A Itterbeek
- A Itterbeek
- A Itterbeek
- A Itterbeek
- A Itterbeek
- A Itterbeek
- A Jaumotte
- A Jaumotte
- A Jobling
- A Jobling
- A Kanitz
- A Klemenc
- A Knappworst
- A Knappworst
- A Kolossowski
- A Korosi
- A Kryagowa
- A Kundt
- A Königer
- A Leontyewa
- A Maman
- A Michels
- A Michels
- A Michels
- A Michels
- A Napolitano
- A Naumowa
- A Pisarew
- A Pochettino
- A Röder
- A Sachanow
- A Sakhanow
- A Schmidt
- A Sellerie
- A Simon
- A Smits
- A Sprung
- A Swinarski
- A Swinarski
- A Timidei
- A Troyer
- A Troyer
- A Troyer De
- A Wijkander
- AA Blanchard
- AA Blanchard
- AA Glagolewa
- AA Mamedow
- AA Romanow
- AA Wertman
- AA Wostryakow
- AA Zalikin
- AB Bdanowskiáż
- AB Cleave
- AB Cleave
- AB Garrett
- AB Garrett
- AC Chatterji
- AC Hollis-Hallett
- AC Hollis-Hallett
- AC Ling
- AC Rocce
- ACD Rivett
- AD Abbott
- AE Dunstan
- AE Dunstan
- AE Dunstan
- AE Dunstan
- AE Dunstan
- AE Dunstan
- AE Dunstan
- AE Dunstan
- AE Dunstan
- AE Dunstan
- AE Dunstan
- AE Dunstan
- AE Dunstan
- AE Luckiy
- AE Luckiy
- AE Schuir
- AE Stearn
- AF Benning
- AF Schmelzle
- AG Amelin
- AG Amelin
- AG Bergman
- AG Clarke
- AG Mussel
- AG Nasini
- AG Nasini
- AG Nasini
- AH Campbell
- AJ Anderson
- AJ Barlow
- AJ Batschinski
- AJ Batschinski
- AJ Batschinski
- AJ Deitsch
- AJ Lewis
- AJ Rabinowitsch
- AJ Teller
- AJ Wyk Van der
- AK Barua
- AK Doolittle
- AK Mukherjee
- AK Par
- AK Par
- AK Ray
- AK Ray
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- AM Samarin
- AMW Aten
- AN Bennett
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- AP Masia
- AP Mills
- AP Toropow
- AR Barbour
- AR Kemp
- AS Chacravarti
- AS Chacravarti
- AS Chacravarti
- AS Golik
- AS Golik
- AS Golik
- AS Golik
- AS Golik
- AS Golik
- AS Karnaukhow
- AS Kertes
- AS Smith
- AS Äernyak
- AV Grosse
- AV Obermayer
- AW Koch
- AW Pamfilow
- AW Pamfilow
- AW Porter
- AW Ralston
- AW Schmidt
- AW Schmidt
- AY DeiÄ
- AY DeiÄ
- B Cornils
- B Latto
- B Longtin
- B Rossmann
- B Tartakowskaya
- B Toplei
- B Vollmer
- BA Arbusow
- BA Cooke
- BA Pospelow
- BD Steele
- BD Steele
- BE Eakin
- BE Eakin
- BE Meyer
- BH Sage
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- BI Stefanow
- BI Werkin
- BJ Best
- BJ Teitelbaum
- BM Fabuss
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- BS Harrap
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- C Antoine
- C Barbe
- C Cartwright
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- C Dodd
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- M Anfilogoff
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- M Giua
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- M Hlasko
- M Hlasko
- M Kaminsky
- M Laue
- M Louis
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- M Mclnally
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- M Mooney
- M Nadi
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- M Poiseuille
- M Poiseuille
- M Prodâhomme
- M Reinganum
- M Rigby
- M Scanavy-Grigoriewa
- M Shimotaki
- M Shimotaki
- M Solomon
- M Souders
- M Stuckgold
- M Sulâgina
- M Tamura
- M Thiesen
- M Trautz
- M Trautz
- M Trautz
- M Trautz
- M Trautz
- M Trautz
- M Trautz
- M Trautz
- M Trautz
- M Trautz
- M Trautz
- M Trautz
- M Trautz
- M Trautz
- M Trautz
- M Trautz
- M Trautz
- M Wildhagen
- M Wogau
- M Yasuda
- M Äepeleweckiáż
- MA Graham
- MA KloÄko
- MA KloÄko
- MA Opykhtina
- MA Weksler
- MC Brinkman
- MC Fontaine-Limbourg
- MD Beludew
- MF Culpin
- MG Frohberg
- MG Frohberg
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- MG Gonikberg
- MG Gonikberg
- MH Gonzales
- MH Gonzalez
- MH Gonzalez
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- MJ Rice
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- MM Karawayew
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- MN States
- MP Applebey
- MP Volarovich
- MP Vukalovitch
- MP Wolarowic
- MR Cannon
- MR Cannon
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- MR Hopkins
- MR Lipkin
- MR Nayar
- MR Nayar
- MS Lyons
- MS Rudenko
- MT Rogers
- MV Dover
- MW Okhotin
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- N Efremow
- N Efremow
- N Eyring
- N Eyring
- NA Agaew
- NA Agayew
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- O Albert
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- O Faust
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- O Halpern
- O Halpern
- O Halpern
- O Köhler
- O Maas
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- O Pulvermacher
- O Reynolds
- O Reynolds
- O Ruff
- O Scarpa
- O Scarpa
- O Scheur
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- O Zimmer
- OA Osipow
- OE Frivold
- OE Meyer
- OF Tower
- OL Hughes
- OL Leipunskii
- OLL Brown
- ON Schokina
- OW Edwards
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- P Assarsson
- P Bidde
- P Breitenbach
- P Breitenbach
- P Brémont
- P Dutoit
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- P Gilard
- P Gilard
- P Goldberg
- P GĂŒnther
- P Harteck
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- P Macedo
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- R Anderson
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- R Fanelli
- R Fanelli
- R Fricke
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- R Gartenmeister
- R Gartenmeister
- R Heinze
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- R Höppler
- R Kalidas
- R Kay
- R Kiyama
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- R Kremann
- R Ladenburg
- R Linke
- R Lorentz
- R Lorenz
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- R Pippo
- R Plank
- R Plank
- R Riemschneider
- R Roscoe
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- RV Helm
- RV Theiss
- RW Gallant
- RW Haywood
- RW Moulton
- RW Schiessler
- RW Schiessler
- RWH Webeler
- S Alamelu
- S Alamelu
- S Arrhenius
- S Brunet
- S Chella
- S Erk
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- S Erk
- S Förster
- S Karpacew
- S Kikuhi
- S Koch
- S Koch
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- S Landa
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- S Makishima
- S Mallikarjun
- S Mathur
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- S Mizushima
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- S Peter
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- S Sheppard
- S Weissman
- S ZĂ€mirea
- SA Mumford
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- SC Barnett
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- SD Gromakow
- SE Babb
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- SF Babak
- SF Babak
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- SN Danilow
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- SP Rao
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- ST Bowden
- ST Dobinski
- ST Dobinski
- SW Holman
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- SZ MikhaĂŒ
- SZ Ć tamowa
- T Doi
- T Doi
- T Doi
- T Erdey-GrĂčz
- T Erdey-GrĂčz
- T Graham
- T Graham
- T Graham
- T Graham
- T Graham
- T Ishikawa
- T Kihara
- T Kihara
- T Kowar
- T Kume
- T Kurucsev
- T Makita
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- T Naiki
- T Onoda
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- T Sagawa
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- T Titani
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- T Tonomura
- T Tonomura
- TC Toye
- TD Ling
- TF Ford
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- TR Lyle
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- TW Jackson
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- TW Yao
- TW Yao
- TY Ju
- V Crescenti
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- V Griffing
- V Gutmann
- V Lantz
- V Vand
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- VC Reinsborough
- VCG Trew
- VD Majumdar
- VE Denny
- VK Venkatesan
- VM Heston
- VR Main
- VR Stott
- VV Chandramouli
- W Bambynek
- W Bambynek
- W Geiseler
- W Groth
- W Herz
- W Herz
- W Herz
- W Herz
- W Herz
- W Herz
- W Herz
- W Koenig
- W Konstantinow
- W Kopsch
- W Krings
- W Licht
- W Lohse
- W Mazer
- W Meissner
- W Menz
- W Morrison-Jackson
- W Ostwald
- W Petrow
- W Pleskow
- W Plotnikow
- W Radecker
- W Riemann
- W Ruckes
- W Schiller
- W Schudel
- W Schugayew
- W Sutherland
- W Tchugayew
- W Weber
- WA Everhart
- WA Granzun
- WA Hare
- WA Hawksworth
- WA Kireew
- WA Pardee
- WA Petrow
- WA Strauss
- WA Unkowskaya
- WA Usolâcewa
- WB Falkowski
- WC McCaughey
- WD Weatherford
- WE Grant
- WE Keller
- WE Keller
- WF Barber
- WF Darke
- WF Giauque
- WF Giauque
- WF Schottky
- WF Seyer
- WG Komarenko
- WG Parks
- WG Shilling
- WH Carothers
- WH Gibson
- WH Harcher
- WH Keesom
- WH Keeson
- WH Mears
- WH Rinkenbach
- WI Semisin
- WI Wallace
- WJ Fisher
- WJ Fisher
- WJ Fisher
- WJ Fisher
- WJ Heikkilla
- WJ Jones
- WJ Thomas
- WJ Wallace
- WK Semencenko
- WL Robb
- WL Sibbit
- WL Zyazew
- WM Bleakney
- WM Cox
- WM Hartford
- WM Jackson
- WN Baker
- WN Baker
- WN Bond
- WN Bond
- WN Cox
- WP Barzakowski
- WP Masowec
- WR Bousfield
- WR Bousfield
- WR Kelly
- WR Wijk
- WRD Jones
- WS Barnhart
- WS Galinker
- WS Galinker
- WS Groenier
- WS Schugayew
- WS Schugayew
- WT Foley
- WT Slawyanskiáż
- WT Slawyanskiáż
- WT Sumarokow
- WV Houston
- WW Pigulewskii
- WW Stender
- WW Steward
- WW Taylor
- WW Udowenko
- WW Udowenko
- WW Udowenko
- WW Udowenko
- WY Anosow
- Y BjornstÄhl
- Y Delcourt
- Y Ishida
- Y Kozlow
- Y Nakagawa
- Y Sing
- Y Suga
- YA Fialkow
- YAL Dutcak
- YAL Dutcak
- YAL Dutcak
- YC Wu
- YM Ping
- YP Gokhstein
- YP Gokhstein
- YS Chiong
- YS Chiong
- YY Fialkow
- YY Fialkow
- YY Fialkow
- YY Fialkow
- YY Fialkow
- YY Fialkow
- Z FriedlÀnder
- Z Golik
- Z Golik
- Z Reyer
- ZW Kondratenko
- ZW Wolkowa
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2013
- Field of study