Role-similarity based functional prediction in networked systems: Application to the yeast proteome

We propose a general method to predict functions of vertices where: 1. The wiring of the network is somehow related to the vertex functionality. 2. A fraction of the vertices are functionally classified. The method is influenced by role-similarity measures of social network analysis. The two versions of our prediction scheme is tested on model networks were the functions of the vertices are designed to match their network surroundings. We also apply these methods to the proteome of the yeast Saccharomyces cerevisiae and find the results compatible with more specialized methods

Expression of CD226 is associated to but not required for NK cell education

AbstractDNAX accessory molecule-1 (DNAM-1, also known as CD226) is an activating receptor expressed on subsets of natural killer (NK) and T cells, interacts with its ligands CD155 or CD112, and has co-varied expression with inhibitory receptors. Since inhibitory receptors control NK-cell activation and are necessary for MHC-I-dependent education, we investigated whether DNAM-1 expression is also involved in NK-cell education. Here we show an MHC-I-dependent correlation between DNAM-1 expression and NK-cell education, and an association between DNAM-1 and NKG2A that occurs even in MHC class I deficient mice. DNAM-1 is expressed early during NK-cell development, precedes the expression of MHC-I-specific inhibitory receptors, and is modulated in an education-dependent fashion. Cd226−/− mice have missing self-responses and NK cells with a normal receptor repertoire. We propose a model in which NK-cell education prevents or delays downregulation of DNAM-1. This molecule endows educated NK cells with enhanced effector functions but is dispensable for education.</jats:p

Discrete concavity and the half-plane property

Murota et al. have recently developed a theory of discrete convex analysis which concerns M-convex functions on jump systems. We introduce here a family of M-concave functions arising naturally from polynomials (over a field of generalized Puiseux series) with prescribed non-vanishing properties. This family contains several of the most studied M-concave functions in the literature. In the language of tropical geometry we study the tropicalization of the space of polynomials with the half-plane property, and show that it is strictly contained in the space of M-concave functions. We also provide a short proof of Speyer's hive theorem which he used to give a new proof of Horn's conjecture on eigenvalues of sums of Hermitian matrices.Comment: 14 pages. The proof of Theorem 4 is corrected

Are Opinions Based on Science: Modelling Social Response to Scientific Facts

As scientists we like to think that modern societies and their members base their views, opinions and behaviour on scientific facts. This is not necessarily the case, even though we are all (over-) exposed to information flow through various channels of media, i.e. newspapers, television, radio, internet, and web. It is thought that this is mainly due to the conflicting information on the mass media and to the individual attitude (formed by cultural, educational and environmental factors), that is, one external factor and another personal factor. In this paper we will investigate the dynamical development of opinion in a small population of agents by means of a computational model of opinion formation in a co-evolving network of socially linked agents. The personal and external factors are taken into account by assigning an individual attitude parameter to each agent, and by subjecting all to an external but homogeneous field to simulate the effect of the media. We then adjust the field strength in the model by using actual data on scientific perception surveys carried out in two different populations, which allow us to compare two different societies. We interpret the model findings with the aid of simple mean field calculations. Our results suggest that scientifically sound concepts are more difficult to acquire than concepts not validated by science, since opposing individuals organize themselves in close communities that prevent opinion consensus.Comment: 21 pages, 5 figures. Submitted to PLoS ON

Neutral theory of chemical reaction networks

To what extent do the characteristic features of a chemical reaction network reflect its purpose and function? In general, one argues that correlations between specific features and specific functions are key to understanding a complex structure. However, specific features may sometimes be neutral and uncorrelated with any system-specific purpose, function or causal chain. Such neutral features are caused by chance and randomness. Here we compare two classes of chemical networks: one that has been subjected to biological evolution (the chemical reaction network of metabolism in living cells) and one that has not (the atmospheric planetary chemical reaction networks). Their degree distributions are shown to share the very same neutral system-independent features. The shape of the broad distributions is to a large extent controlled by a single parameter, the network size. From this perspective, there is little difference between atmospheric and metabolic networks; they are just different sizes of the same random assembling network. In other words, the shape of the degree distribution is a neutral characteristic feature and has no functional or evolutionary implications in itself; it is not a matter of life and death.Comment: 13 pages, 8 figure

GREEN ACCOUNTING IN NORWEGIAN CONSTRUCTION

This master’s thesis aims to explore the application of Environmental Management Accounting (EMA) in the Norwegian construction industry. EMA is an accounting method that assists companies in identifying, measuring, and managing their environmental impacts, costs, and benefits. With the introduction of the Corporate Sustainable Reporting Directive (CSRD) in the EU, more actors in the industry will be required to report in accordance with the European Sustainability Reporting Standards (ESRS), which include Environmental, Social & Governance (ESG) reporting requirements. To achieve the objectives of the thesis, a qualitative multi-case study has been conducted, involving five selected actors in the construction industry who will fall under the scope of CSRD in 2024/25. The study maps out how these companies use EMA for reporting purposes and how their control systems facilitate effective reporting. The findings reveal significant variation in the level of EMA use and associated tools among the companies in the industry studied. Companies with a longer history of sustainability reporting demonstrate greater sophistication in their use of EMA. These companies possess more advanced tools and have automated reporting processes to a greater extent. However, the implementation of EMA faces several challenges in the industry, including the complexity of the CSRD, underdeveloped data collection tools, and the management of substantial amounts of data. The insights generated from this master’s thesis provide a systematic overview of EMA practices in the Norwegian construction industry while also identifying challenges that need to be addressed to achieve more efficient and comprehensive reporting in line with CSRD and ESRS

Symmetry-allowed phase transitions realized by the two-dimensional fully frustrated XY class

A 2D Fully Frustrated XY(FFXY) class of models is shown to contain a new groundstate in addition to the checkerboard groundstates of the standard 2D FFXY model. The spin configuration of this additional groundstate is obtained. Associated with this groundstate there are additional phase transitions. An order parameter accounting for these new transitions is proposed. The transitions associated with the new order parameter are suggested to be similar to a 2D liquid-gas transition which implies Z_2-Ising like transitions. This suggests that the class of 2D FFXY models belongs within a U(1) x Z_2 x Z_2-designation of possible transitions, which implies that there are seven different possible single and combined transitions. MC-simulations for the generalized fully frustrated XY (GFFXY) model on a square lattice are used to investigate which of these possibilities can be realized in practice: five of the seven are encountered. Four critical points are deduced from the MC-simulations, three consistent with central charge c=3/2 and one with c=1. The implications for the standard 2D FFXY-model are discussed in particular with respect to the long standing controversy concerning the characteristics of its phase transitions.Comment: 8 pages, 8 figure