13 research outputs found
PRM29 METHODOLOGICAL DIFFERENCES IN EQ-5D SCORING SYSTEMS: A SYSTEMATIC REVIEW AND ANALYSIS
Factors associated with large increases in self-reported health status in infliximab-treated inflammatory bowel disease patients: results from the bioadvance survey
Comparing EQ-5D valuation studies: A systematic review and methodological reporting checklist
PMD25 THE COST-UTILITY AND VALUE OF INFORMATION OF TRANSCATHETER AORTIC VALVE IMPLANTATION COMPARED TO STANDARD MANAGEMENT AND SURGICAL AORTIC VALVE REPLACEMENT IN PATIENTS WITH SEVERE SYMPTOMATIC AORTIC VALVE STENOSIS
Magnetically Coated Bioabsorbable Stents for Renormalization of Arterial Vessel Walls after Stent Implantation
The
insertion of a stent in diseased arteries is a common endovascular
procedure that can be compromised by the development of short- and
long-term inflammatory responses leading to restenosis and thrombosis,
respectively. While treatment with drugs, either systemic or localized,
has decreased the incidence of restenosis and thrombosis these complications
persist and are associated with a high mortality in those that present
with stent thrombosis. We reasoned that if stents could be made to
undergo accelerated endothelialization in the deployed region, then
such an approach would further decrease the occurrence of stent thrombosis
and restenosis thereby improving clinical outcomes. Toward that objective,
the first step necessitated efficient capture of progenitor stem cells,
which eventually would become the new endothelium. To achieve this
objective, we engineered intrinsic ferromagnetism within nonmagnetizable,
biodegradable magnesium (Mg) bare metal stents. Mg stents were coated
with biodegradable polylactide (PLA) polymer embedding magnetizable
iron–platinum (FePt) alloy nanoparticles, nanomagnetic particles, <sup>n</sup>Mags, which increased the surface area and hence magnetization
of the stent. <sup>n</sup>Mags uniformly distributed on stents enabled
capture, under flow, up to 50 mL/min, of systemically injected iron-oxide-labeled
(IO-labeled) progenitor stem cells. Critical parameters enhancing
capture efficiency were optimized, and we demonstrated the generality
of the approach by showing that <sup>n</sup>Mag-coated stents can
capture different cell types. Our work is a potential paradigm shift
in engineering stents because implants are rendered as tissue in the
body, and this “natural stealthiness” reduces or eliminates
issues associated with pro-inflammatory immune responses postimplantation