692 research outputs found
Extensions of C*-dynamical systems to systems with complete transfer operators
Starting from an arbitrary endomorphism of a unital C*-algebra
we construct a bigger C*-algebra and extend onto in such a way
that the extended endomorphism has a unital kernel and a hereditary
range, i.e. there exists a unique non-degenerate transfer operator for
, called the complete transfer operator. The pair is
universal with respect to a suitable notion of a covariant representation and
depends on a choice of an ideal in . The construction enables a natural
definition of the crossed product for arbitrary .Comment: Compressed and submitted version, 9 page
Lack of expression of preproorexin and orexin receptors genes in human normal and prostate cancer cell lines
Introduction. Studies on expression of orexins (OXs) and their receptors in human prostate gland and human prostatic cell lines are scanty and their results contradictory. Regarding this, we carefully reinvestigated this problem on human prostatic cell lines.
Material and methods. Expression of preproorexin (ppOX) (6 primer pairs), and orexin receptors 1 and 2 (OXR1, OXR2) (4 and 2 primer pairs, respectively) was assessed by conventional PCR and QPCR in human normal (PrEC, PrSc, PrSmC) and prostate carcinoma (Du145, LNCaP, and PC3) cell lines. We designed intron spanning primers and also we applied primers from earlier publications and commercially available ones.
Results. With the designed primer pairs, in all studied cell lines we failed to demonstrate expression of ppOX, OXR1 and OXR2 genes at the mRNA level, while reaction products were observed in control tissues (human placenta and adrenals). Primers applied in earlier studies did not form amplification products specific for preproorexin or orexin 1 receptor. Some commercially available primers for orexin receptor 1 produced false positive results.
Conclusions. We found no evidence for the presence of preproorexin–orexin receptors system genes’ mRNAs in human prostate cell lines. The reported premises for these genes’ expression in prostate and prostatic cell lines may have arisen either from the presence of non-prostate cells included in the samples or from faulty PCR settings
Spin Foams and Noncommutative Geometry
We extend the formalism of embedded spin networks and spin foams to include
topological data that encode the underlying three-manifold or four-manifold as
a branched cover. These data are expressed as monodromies, in a way similar to
the encoding of the gravitational field via holonomies. We then describe
convolution algebras of spin networks and spin foams, based on the different
ways in which the same topology can be realized as a branched covering via
covering moves, and on possible composition operations on spin foams. We
illustrate the case of the groupoid algebra of the equivalence relation
determined by covering moves and a 2-semigroupoid algebra arising from a
2-category of spin foams with composition operations corresponding to a fibered
product of the branched coverings and the gluing of cobordisms. The spin foam
amplitudes then give rise to dynamical flows on these algebras, and the
existence of low temperature equilibrium states of Gibbs form is related to
questions on the existence of topological invariants of embedded graphs and
embedded two-complexes with given properties. We end by sketching a possible
approach to combining the spin network and spin foam formalism with matter
within the framework of spectral triples in noncommutative geometry.Comment: 48 pages LaTeX, 30 PDF figure
Weak charge form factor and radius of 208Pb through parity violation in electron scattering
We use distorted wave electron scattering calculations to extract the weak
charge form factor F_W(q), the weak charge radius R_W, and the point neutron
radius R_n, of 208Pb from the PREX parity violating asymmetry measurement. The
form factor is the Fourier transform of the weak charge density at the average
momentum transfer q=0.475 fm. We find F_W(q) =0.204 \pm 0.028 (exp) \pm
0.001 (model). We use the Helm model to infer the weak radius from F_W(q). We
find R_W= 5.826 \pm 0.181 (exp) \pm 0.027 (model) fm. Here the exp error
includes PREX statistical and systematic errors, while the model error
describes the uncertainty in R_W from uncertainties in the surface thickness
\sigma of the weak charge density. The weak radius is larger than the charge
radius, implying a "weak charge skin" where the surface region is relatively
enriched in weak charges compared to (electromagnetic) charges. We extract the
point neutron radius R_n=5.751 \pm 0.175 (exp) \pm 0.026 (model) \pm 0.005
(strange) fm$, from R_W. Here there is only a very small error (strange) from
possible strange quark contributions. We find R_n to be slightly smaller than
R_W because of the nucleon's size. Finally, we find a neutron skin thickness of
R_n-R_p=0.302\pm 0.175 (exp) \pm 0.026 (model) \pm 0.005 (strange) fm, where
R_p is the point proton radius.Comment: 5 pages, 1 figure, published in Phys Rev. C. Only one change in this
version: we have added one author, also to metadat
A high-finesse Fabry-Perot cavity with a frequency-doubled green laser for precision Compton polarimetry at Jefferson Lab
A high-finesse Fabry-Perot cavity with a frequency-doubled continuous wave
green laser (532~nm) has been built and installed in Hall A of Jefferson Lab
for high precision Compton polarimetry. The infrared (1064~nm) beam from a
ytterbium-doped fiber amplifier seeded by a Nd:YAG nonplanar ring oscillator
laser is frequency doubled in a single-pass periodically poled MgO:LiNbO
crystal. The maximum achieved green power at 5 W IR pump power is 1.74 W with a
total conversion efficiency of 34.8\%. The green beam is injected into the
optical resonant cavity and enhanced up to 3.7~kW with a corresponding
enhancement of 3800. The polarization transfer function has been measured in
order to determine the intra-cavity circular laser polarization within a
measurement uncertainty of 0.7\%. The PREx experiment at Jefferson Lab used
this system for the first time and achieved 1.0\% precision in polarization
measurements of an electron beam with energy and current of 1.0~GeV and
50~A.Comment: 20 pages, 22 figures, revised version of arXiv:1601.00251v1,
submitted to NIM
Viscoelastic properties of differentiating blood cells are fate- and function-dependent
This is the final version of the article. Available from the publisher via the DOI in this record.Although cellular mechanical properties are known to alter during stem cell differentiation, understanding of the functional relevance of such alterations is incomplete. Here, we show that during the course of differentiation of human myeloid precursor cells into three different lineages, the cells alter their viscoelastic properties, measured using an optical stretcher, to suit their ultimate fate and function. Myeloid cells circulating in blood have to be advected through constrictions in blood vessels, engendering the need for compliance at short time-scales (minutes), compared to undifferentiated cells. These findings suggest that reduction in steady-state viscosity is a physiological adaptation for enhanced migration through tissues. Our results indicate that the material properties of cells define their function, can be used as a cell differentiation marker and could serve as target for novel therapies.Funding: The authors acknowledge financial support by the Cambridge Commonwealth Trust (to AEE; http://www.cambridgetrusts.org), the Medical Research
Council (to KC and JG; grant number: 94185; http://www.mrc.ac.uk), the Human Frontier Science Program (to GW and JG; grant number: RGP0015/2009-C; http://
www.hfsp.org) and the European Research Council (to JG; grant number: 282060; http://erc.europa.eu)
Feynman problem in the noncommutative case
In the context of the Feynman's derivation of electrodynamics, we show that
noncommutativity allows other particle dynamics than the standard formalism of
electrodynamics.Comment: latex, 7 pages, no figure
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