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    āŠļāŦāŠĩāŠūāŠŪāŠŋāŠĻāŠūāŠ°āŠūāŠŊāŠĢ āŠļāŠ‚āŠŠāŦāŠ°āŠĶāŠūāŠŊāŠĻāŠū āŠĪāŠĪāŦāŠĩāŠœāŦāŠžāŠūāŠĻ āŠĶāŦāŠĩāŠūāŠ°āŠū āŠ­āŠūāŠ°āŠĪāŦ€āŠŊ āŠ‰āŠĶāŦāŠŊāŦ‹āŠ—āŠ•āŠ°āŦāŠĪāŠūāŠ“āŠĻāŦ€ āŠļāŠ‚āŠšāŠūāŠēāŠ•āŦ€āŠŊ āŠļāŠŪāŠļāŦāŠŊāŠūāŠ“āŠĻāŠū āŠ‰āŠ•āŦ‡āŠēāŠĻāŦ‹ āŠ…āŠ­āŦāŠŊāŠūāŠļ

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    āŠ­āŠūāŠ°āŠĪ āŠļāŦŒāŠĨāŦ€ āŠŠāŦāŠ°āŠūāŠšāŦ€āŠĻ āŠ…āŠĻāŦ‡ āŠĩāŦˆāŠĶāŠŋāŠ• āŠļāŠ‚āŠļāŦāŠ•āŦƒāŠĪāŠŋ āŠ…āŠĻāŦ‡ āŠĩāŠŋāŠšāŠūāŠ°āŠ§āŠūāŠ°āŠū āŠ§āŠ°āŠūāŠĩāŠĪāŦāŠ‚ āŠļāŦāŠļāŠ‚āŠļāŦāŠ•āŦƒāŠĪ āŠ°āŠūāŠ·āŦāŠŸāŦāŠ° āŠ›āŦ‡. āŠļāŦŒ āŠŠāŦāŠ°āŠĨāŠŪ āŠ­āŠūāŠ°āŠĪāŦ‡ āŠļāŠŪāŠ—āŦāŠ° āŠĩāŠŋāŠķāŦāŠ°āŦāŠĩāŠĻāŦ‡ āŠŪāŠūāŠĻāŠĩāŠœāŦ€āŠĩāŠĻāŠĻāŦ€ āŠķāŠ°āŦ‚āŠ†āŠĪāŠŪāŠūāŠ‚ āŠļāŠ‚āŠļāŦāŠ•āŠūāŠ°āŦ€āŠĪāŠū āŠ…āŠĻāŦ‡ āŠķāŦāŠ°āŦ‡āŠ·āŦāŠ āŠĪāŠŪ āŠĩāŠŋāŠšāŠūāŠ°āŦ‹āŠĻāŦ€ āŠ°āŠœāŦ‚āŠ†āŠĪ āŠ†āŠŠāŦ€. āŠŪāŠ°āŦāŠŊāŠūāŠĶāŠŋāŠĪ āŠĩāŦāŠŊāŠūāŠŠāŠūāŠ°āŠ•āŦāŠ·āŦ‡āŠĪāŦāŠ°āŠŪāŠūāŠ‚āŠĨāŦ€ āŠ‰āŠĪāŦāŠĪāŠ°āŦ‹āŠĪāŦāŠĪāŠ° āŠŽāŦāŠ°āŠŋāŠŸāŦ€āŠķ āŠķāŠūāŠļāŠ•āŦ‹āŠĻāŠū āŠĻāŦ‡āŠœāŠū āŠĻāŦ€āŠšāŦ‡ āŠĩāŠŋāŠķāŠūāŠģāŠŠāŠūāŠŊāŠū āŠŠāŠ° āŠ‰āŠĪāŦāŠŠāŠūāŠĶāŠĻ āŠ–āŠ°āŦ€āŠĶ-āŠĩāŦ‡āŠ‚āŠšāŠūāŠĢ āŠ…āŠĻāŦ‡ āŠļāŠ‚āŠšāŠūāŠēāŠ•āŠŋāŠŊ āŠ•āŠūāŠŪāŠ—āŦ€āŠ°āŦ€ āŠ…āŠļāŦāŠĪāŠŋāŠĪāŦāŠĩāŠŪāŠūāŠ‚ āŠ†āŠĩāŦ€. āŠĪāŦ‡āŠŪāŠœ āŠŽāŦāŠ°āŠŋāŠŸāŦ€āŠķ āŠķāŠūāŠļāŠ•āŦ‹āŠĻāŠū āŠķāŠūāŠļāŠĻāŠŪāŠūāŠ‚ āŠ­āŠūāŠ°āŠĪāŠĻāŦ€ āŠ†āŠ°āŦāŠĨāŠŋāŠ•, āŠļāŠūāŠŪāŠūāŠœāŠŋāŠ•, āŠ°āŠūāŠœāŠ•āŠŋāŠŊ āŠŠāŠ°āŠŋāŠļāŦāŠĨāŠŋāŠĪāŠŋ āŠĩāŠ§āŦ āŠĩāŠŋāŠ•āŠŸ āŠŽāŠĻāŦ€ āŠ…āŠĻāŦ‡ āŠ”āŠĶāŦāŠŊāŦ‹āŠ—āŠŋāŠ• āŠ•āŦāŠ°āŠūāŠ‚āŠĪāŠŋāŠĻāŠū āŠŪāŠ‚āŠĄāŠūāŠĢ āŠĨāŠĪāŠū āŠ—āŦƒāŠđāŠ‰āŠĶāŦāŠŊāŦ‹āŠ—āŦ‹ āŠ…āŠĻāŦ‡ āŠĻāŠūāŠĻāŠūāŠŠāŠūāŠŊāŠūāŠĻāŠū āŠ§āŠ‚āŠ§āŠū-āŠ‰āŠĶāŦāŠŊāŦ‹āŠ—āŦ‹āŠĻāŦ‹ āŠ°āŠ•āŠūāŠļ āŠĨāŠŊāŦ‹. āŠ†āŠāŠūāŠĶāŦ€ āŠŠāŠ›āŦ€ āŠŠāŠĢ āŠ­āŠūāŠ°āŠĪāŠŪāŠūāŠ‚ āŠŠāŠ°āŠĶāŦ‡āŠķāŦ€ āŠĩāŠŋāŠšāŠūāŠ°āŠ§āŠūāŠ°āŠū āŠ…āŠŪāŠēāŠŪāŠūāŠ‚ āŠ°āŠđāŦ‡āŠĪāŠū āŠ­āŠūāŠ°āŠĪ āŠĶāŦ‡āŠķāŦ‡ āŠĩāŠŋāŠ•āŠūāŠļ āŠĪāŦ‹ āŠ•āŠ°āŦāŠŊāŦ‹ āŠĪāŦ‡āŠĻāŦ€ āŠļāŠūāŠĨāŦ‡ āŠ…āŠŪāŦ‡āŠ°āŠŋāŠ•āŠĻ āŠļāŠ‚āŠšāŠūāŠēāŠĻ āŠĩāŠŋāŠšāŠūāŠ°āŠ§āŠūāŠ°āŠū āŠ…āŠĻāŦ‡ āŠœāŠūāŠŠāŠūāŠĻāŦ€āŠ āŠļāŠ‚āŠšāŠūāŠēāŠĻ āŠĩāŠŋāŠšāŠūāŠ°āŠ§āŠūāŠ°āŠū āŠœāŦ‡āŠĩāŦ€ āŠĩāŠŋāŠĶāŦ‡āŠķāŦ€ āŠĩāŠŋāŠšāŠūāŠ°āŠ§āŠūāŠ°āŠūāŠĻāŦ‹ āŠĩāŠŋāŠ•āŠūāŠļ āŠĨāŠŊāŦ‹, āŠŠāŠ°āŠ‚āŠĪāŦ āŠļāŦŒāŠĨāŦ€ āŠŪāŦ‹āŠŸāŦ€ āŠļāŠŪāŠļāŦāŠŊāŠūāŠ āŠĨāŠˆ āŠ•āŦ‡ āŠ†āŠŠāŠĢāŠū āŠŪāŦ‚āŠēāŦāŠŊāŦ‹, āŠļāŠŋāŠ§āŦāŠ§āŠūāŠ‚āŠĪāŦ‹, āŠ°āŦ€āŠĪāŠŋāŠĻāŦ€āŠĪāŠŋ āŠĩāŠ—āŦ‡āŠ°āŦ‡āŠŪāŠūāŠ‚ āŠŪāŦāŠģ āŠĩāŦˆāŠĶāŠŋāŠ•āŠŪāŦ‚āŠēāŦāŠŊāŦ‹ āŠ…āŠĻāŦ‡ āŠļāŠ‚āŠļāŦāŠ•āŠūāŠ°āŦ€āŠĪāŠū āŠŠāŠĄāŦ€ āŠđāŠĪāŦ€. āŠœāŦāŠŊāŠūāŠ°āŦ‡ āŠŠāŠ°āŠĶāŦ‡āŠķāŦ€ āŠĩāŠŋāŠšāŠūāŠ°āŠ§āŠūāŠ°āŠū āŠļāŠūāŠĨāŦ‡ āŠĪāŦ‡āŠĻāŦ‹ āŠļāŦāŠŪāŦ‡āŠģ āŠĻ āŠđāŠĪāŦ‹. āŠŠāŠ°āŦ€āŠĢāŠūāŠŪāŦ‡ āŠ†āŠĩāŦ€ āŠĩāŠŋāŠ·āŠŪ āŠŠāŠ°āŠŋāŠļāŦāŠĨāŠŋāŠĪāŠŋ āŠļāŠ°āŦāŠœāŠūāŠĪāŠū āŠ§āŠ‚āŠ§āŠūāŠ•āŦ€āŠŊ āŠŠāŠ°āŦāŠŊāŠūāŠĩāŠ°āŠĢāŠĻāŦ‡ āŠŠāŠ°āŠĶāŦ‡āŠķāŦ€ āŠĩāŠŋāŠšāŠūāŠ°āŠ§āŠūāŠ°āŠū āŠŪāŠūāŠŦāŦāŠ• āŠĻ āŠ†āŠĩāŦ€ āŠ…āŠĻāŦ‡ āŠ•āŦāŠĶāŠ°āŠĪāŦ€, āŠŪāŠūāŠĻāŠĩāŦ€āŠŊ āŠ…āŠĻāŦ‡ āŠŽāŦŒāŠ§āŦāŠ§āŠŋāŠ• āŠķāŠ•āŦāŠĪāŠŋ āŠđāŦ‹āŠĩāŠū āŠ›āŠĪāŠūāŠ‚ āŠ­āŠūāŠ°āŠĪāŠĶāŦ‡āŠķ āŠļāŠ‚āŠšāŠūāŠēāŠĻ āŠ•āŦāŠ·āŦ‡āŠĪāŦāŠ°āŦ‡ āŠ…āŠēāŦāŠŠāŠĩāŠŋāŠ•āŠļāŠŋāŠĪ āŠ°āŠđāŦāŠŊāŦ‹. āŠŠāŦāŠ°āŠļāŦāŠĪāŦāŠĪ āŠķāŦ‹āŠ§āŠĻāŠŋāŠŽāŠ‚āŠ§ āŠĶāŦāŠĩāŠūāŠ°āŠū āŠļāŠ‚āŠķāŦ‹āŠ§āŠ•āŠĻāŦ‹ āŠ‰āŠĶāŦ‡āŠķ āŠļāŦāŠĩāŠūāŠŪāŠŋāŠĻāŠūāŠ°āŠūāŠŊāŠĢ āŠļāŠ‚āŠŠāŦāŠ°āŠĶāŠūāŠŊāŠĻāŦ‹ āŠ‰āŠĶāŦāŠ­āŠĩ āŠ•āŦ‡āŠĩāŦ€ āŠ°āŦ€āŠĪāŦ‡ āŠĨāŠŊāŦ‹ āŠĪāŦ‡āŠŪāŠœ āŠķāŦāŠ°āŦ€āŠļāŠđāŠœāŠūāŠĻāŠ‚āŠĶāŠļāŦāŠĩāŠūāŠŪāŦ€āŠĻāŦāŠ‚ āŠœāŦ€āŠĩāŠĻ āŠ…āŠĻāŦ‡ āŠĪāŦ‡āŠŪāŠĻāŠū āŠĶāŦāŠĩāŠūāŠ°āŠū āŠ­āŠūāŠ°āŠĪāŠĻāŦ€ āŠŠāŠĩāŠŋāŠĪāŦāŠ°āŠ­āŦ‚āŠŪāŦ€ āŠŠāŠ° āŠĨāŠŊāŦ‡āŠē āŠŊāŦāŠ—āŠ•āŠūāŠ°āŦāŠŊāŠĻāŦ‡ āŠļāŠ‚āŠ•āŦāŠ·āŦ€āŠŠāŦāŠĪāŠŪāŠūāŠ‚ āŠļāŠŪāŠœāŠĩāŠūāŠĻāŦ‹ āŠ›āŦ‡. āŠĪāŦ‡āŠŪāŠĻāŦ€ āŠŪāŠūāŠĻāŦ‚āŠ·āŦ€āŠēāŦ€āŠēāŠū, āŠāŠķāŦāŠ°āŦāŠĩāŠ°āŦāŠŊ, āŠšāŠūāŠ°āŠŋāŠĪāŦāŠ°āŦāŠŊ, āŠĻāŦˆāŠĪāŠŋāŠ•āŠĪāŠū, āŠļāŠĶāŦāŠ—āŦāŠĢāŠŊāŦāŠ•āŦāŠĪ āŠ†āŠšāŠ°āŠĢāŠ­āŠ° āŠœāŦ€āŠĩāŠĻ āŠ…āŠĻāŦ‡ āŠ•āŠĩāŠĻāŠĻāŠū āŠĶāŠ°āŦ‡āŠ• āŠŠāŠūāŠļāŠūāŠĻāŦ€ āŠļāŦāŠ•āŦāŠ·āŦāŠŪāŠ›āŠĢāŠūāŠĩāŠŸ āŠ…āŠĻāŦ‡ āŠĪāŦ‡āŠŪāŠĢāŦ‡ āŠ†āŠŠāŦ‡āŠē āŠĪāŠĪāŦāŠĩāŠœāŦāŠžāŠūāŠĻ āŠļāŦāŠĩāŠūāŠŪāŠŋāŠĻāŠūāŠ°āŠūāŠŊāŠĢ āŠļāŠūāŠđāŠŋāŠĪāŦāŠŊāŠĻāŠū āŠ…āŠ­āŦāŠŊāŠūāŠļ āŠĶāŦāŠĩāŠūāŠ°āŠū āŠļāŠ‚āŠķāŦ‹āŠ§āŠ•āŦ‡ āŠ°āŠœāŦ‚ āŠ•āŠ°āŦ‡āŠē āŠ›āŦ‡

    Metabolic disposition of a monoterpene ketone, piperitenone, in rats: evidence for the formation of a known toxin,p-cresol

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    It was shown earlier that the monoterpene ketone, piperitenone (I) is one of the major metabolites of R-(+)-pulegone, a potent hepatotoxin. In the present studies, the metabolic disposition of piperitenone (I) was examined in rats. Piperitenone (I) was administered orally (400 mg/kg of the b. wt./day) to rats for 5 days. The following urinary metabolites were isolated and identified by various spectral analyses: p-cresol (VI), 6,7-dehydromenthofuran (III), p-mentha-1,3,5,8-tetraen-3-ol (IX), p-mentha-1, 3,5-triene-3, 8-diol (X), 5-hydroxypiperitenone (VIII), 7-hydroxypiperitenone (XI), 10-hydroxypiperitenone (XII), and 4-hydroxypiperitenone (VII). Incubation of piperitenone (I) with phenobarbital-induced rat liver microsomes in the presence of NADPH resulted in the formation of five metabolites which have been tentatively identified as metabolites III, VII, VIII, XI, XII, on the basis of gas chromatography retention time and gas chromatography-mass spectrometry analysis. Based on these results, a probable mechanism for the formation of p-cresol from piperitenone (I) via the intermediacy of metabolite III has been proposed

    Incidence and distribution of congenital malformations clinically detected at birth: a prospective study at tertiary care hospital

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    Background: Congenital malformation represents defects in morphogenesis during early fetal life. Congenital anomalies account for 8-15% of perinatal deaths and 13-16% of neonatal deaths in India. The objective was to study overall and individual incidence and distribution of clinically detectable congenital malformations in newborns delivered at a tertiary hospital.Methods: The present study is a prospective study of all the newborns delivered at Obstetrics and Gynecology Department, New Civil Hospital, Surat, Gujarat, India for a period of one year from 1st January 2010 to 31st December 2010. Total 5518 consecutive births including both live born babies and still born babies were examined after taking verbal and written consent of their mothers for a visible structural anomalies to determine the overall incidence and distribution of congenital malformations. Data were statistically analyzed using SPSS software (trial version).Results: A total of 5518 babies were born out of which 75 were twins. Out of total 5518 newborns 5316 were live births and 202 were still births and out of 5316 live births 48 babies were malformed and out of 202 still births 20 babies were malformed. Total numbers of malformed babies were 68, so total point incidence of congenital anomalies turned out to be 1.23%. Out of total 5518 babies, 35 (0.63%) were having central nervous system malformations making its incidence of 6.34/1000 live births which turned out to be highest followed by gastrointestinal system (incidence of malformed babies: 5.44/1000 births) and genitor urinary system (incidence of malformed babies :1.09/1000 births). Commonest anomalies in central nervous system were meningomyelocele followed by hydrocephalus and anencephaly.Conclusions: From present study we conclude that incidence of congenital anomalies of CNS was highest amongst all types of congenital anomalies (meningomyelocele being the commonest). More emphasis should be given on prevention by regular antenatal care and avoidance of known teratogens and probable teratogenic agents

    A study on incidence of congenital anomalies in new borns and their association with fetal factors: a prospective study

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    Background: Congenital malformation represents defects in morphogenesis during early fetal life. Congenital anomalies account for 8–15% of perinatal deaths and 13–16% of neonatal deaths in India. The objective was to study incidence of clinically detectable congenital malformations in new-borns delivered at a tertiary hospital and their association with fetal factors.Methods: The present study is a prospective study of all the newborns delivered at Obstetrics and Gynecology Department, New Civil Hospital, Surat for a period of one year from 1st January 2010 to 31st December 2010. Total 5518 consecutive births including both live born babies and still born babies were examined after taking verbal and written consent of their mothers for a visible structural anomalies to determine the overall incidence and distribution of congenital malformations and their association with fetal factors. Data were statistically analyzed using SPSS software (trial version).Results: A total of 5518 babies were born out of which 75 were twins. Total numbers of malformed babies were 68, so total point incidence of congenital anomalies turned out to be 1.23%. There were 2963 male new-borns, out of that 40 were congenitally malformed (1.34%) and out of 2555 female new-borns 28 were congenitally malformed (1.09%). No significant association was found between congenital malformation and sex of the child. Out of total 5518 new-borns 5316 were live births and 202 were still births and out of 5316 live births 48 babies were malformed and out of 202 still births 20 babies were malformed. Out of total 5518 new-borns 1227 had birth weight less than 1500 grams and out of them 12 (0.97%) babies were congenitally malformed. Out of 5518 new-borns 221 were preterm babies and out of 221 preterm babies 26 (12.32%) babies were congenitally malformed.Conclusions: From present study it has been concluded that congenital anomalies in new-borns were significantly associated with fetal factors like still birth, prematurity and low birth weight
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