DESIGN AND EVALUATION OF NOVEL TOPICAL GEL OF TINOSPORA CORDIFOLIA AS ANTIMICROBIAL AGENT

Objective: The present study deals with topical formulations of a bioactive extract of Tinospora cordifolia and its evaluation.Methods: Dried, powdered stem was extracted with chloroform using ultra-sonication method for 3 hrs. Topical formulations like gels containingchloroform extract were formulated using various gelling agents. These gels were evaluated for physicochemical parameters, viscosity, spreadaibility,and antimicrobial activity.Results: A topical gel was successfully formulated containing bioactive chloroform extract of T. cordifolia. The gel was very effective as antimicrobialformulations.Conclusion: These kinds of formulations can be very promising wound healing medicines with ease of use and no side effects.Keywords: Topical gel, Tinospora Cordifolia, Anitmictobia

A Review on Metabolic Syndrome

Metabolic syndrome is considered a major reason for the emergence of chronic dreadful diseases. Obesity and wrong food habit are key factors for metabolic syndrome. Globally people are affected by glucose intolerance, central obesity, hypertension, and dyslipidemia. Diabetes is a major part of metabolic syndrome. Targeted anti-inflammatory therapy has been suggested for both prevention and treatment of many of the above-said syndrome especially diabetes. Diet is an important regulatory factor in the immune response. There is considerable evidence to suggest that malnutrition leads to immune suppression due to a susceptibility to infection. On the other hand, over-nutrition leads to immune activation due to a susceptibility to an inflammatory condition. Inflammation may have an important role in the development and progression of diabetes and its complications; however, the impact of experimental anti-inflammatory treatments on diabetes deterioration over time and cardiovascular outcomes is still elusive. Thus proper diet with some drug therapy not only resolves the issue but can prevent the progression of the disease at extreme levels