17 research outputs found
A novel anti-inflammatory natural product from Sphaeranthus indicus inhibits expression of VCAM1 and ICAM1, and slows atherosclerosis progression independent of lipid changes
Estrogenic effect of Erythrina variegata L. in prepubertal female rats
Alcoholic extract of Erythrina variegata L. leaves was evaluated by uterotrophic assay in 17 day old prepubertal female rats and was chromatographically processed for compound isolation. The animals divided into 3 (n=6) groups were treated for 7 days as follows: Control group (Grp I) –vehicle, 0.5% Na CMC, 5 mL/kg bw p.o, E. variegata alcohol extract group (Grp II) – 250 mg/kg bw/day in vehicle p.o., Ethinyl estradiol group (Grp III) - 30μg/kg bw/day in vehicle, p.o. 24 h post last exposure to extract. Animals were sacrificed and the uterus and ovaries examined for classical morphological and histomorphometric changes induced by estrogen stimulation. Extract treatment increased the absolute and normalized uterine weight, uterine diameter, endometrial thickness, luminal epithelial cell height, diameter of ovary and the number of primary and secondary ovarian follicles relative to vehicle control. Presence of ciliated epithelial cells in the oviduct and signs of vascularization in the cortex of ovarian sections in this group similar to EEG is indicative of estrogenic activity of the tested extract. This is consequent to the antioxidant activity of β-sitosterol, daucosterol and oleanolic isolated from the extract. This study supports the earlier reported hypolipidaemic and anti-atherosclerotic activities, lending scientific validity to anti-obesity claims in traditional medicine
Estrogenic effect of <i style="mso-bidi-font-style: normal">Erythrina variegata</i> L. in prepubertal female rats
223-227Alcoholic extract of <i style="mso-bidi-font-style:
normal">Erythrina variegata L. leaves was evaluated by uterotrophic assay
in 17 day old prepubertal female rats and was chromatographically processed for
compound isolation. The animals divided into 3 (n=6) groups were treated for 7
days as follows: Control group (Grp I) –vehicle, 0.5% Na CMC, 5 mL/kg bw p.o, E. variegata alcohol extract group (Grp
II) – 250 mg/kg bw/day in vehicle p.o., Ethinyl estradiol group (Grp III) -
30ÎĽg/kg bw/day in vehicle, p.o. 24 h post last exposure to extract. Animals
were sacrificed and the uterus and ovaries examined for classical morphological
and histomorphometric changes induced by estrogen stimulation. Extract
treatment increased the absolute and normalized uterine weight, uterine
diameter, endometrial thickness, luminal epithelial cell height, diameter of
ovary and the number of primary and secondary ovarian follicles relative to
vehicle control. Presence of ciliated epithelial cells in the oviduct and signs
of vascularization in the cortex of ovarian sections in this group similar to
EEG is indicative of estrogenic activity of the tested extract. This is
consequent to the antioxidant activity of β-sitosterol, daucosterol and
oleanolic isolated from the extract. This study supports the earlier reported
hypolipidaemic and anti-atherosclerotic activities, lending scientific validity
to anti-obesity claims in traditional medicine