Synthesis and characterisation of Fe₆ and Fe₁₂ clusters using bicine

Reaction of bicine {BicH3, N,N-bis(2-hydroxyethyl)glycine} with an Fe(III) oxo-centered pivalate triangle in MeCN in the presence of Et<sub>2</sub>NH yields [Et<sub>2</sub>NH<sub>2</sub>]<sub>2</sub>[Fe<sub>6</sub>O<sub>2</sub>(OH)<sub>2</sub>(Bic)<sub>2</sub>(O<sub>2</sub>CCMe<sub>3</sub>)<sub>8</sub>], which possesses an S = 5 ground state. Changing the base to NaOMe produces [Fe<sub>12</sub>O<sub>4</sub>(Bic)<sub>4</sub>(HBic)<sub>4</sub>(O<sub>2</sub>CCMe<sub>3</sub>)<sub>8</sub>], which contains two Fe6 units bridged by the carboxylate arms from the bicine ligands. The complex displays strong antiferromagnetic coupling leading to an S = 0 ground state

Biological implications of a discrete mathematical model for collagen deposition and alignment in dermal wound repair

We deveiop a novel mathematical model for collagen deposition and alignment during dermal wound healing. We focus on the interactions between fibroblasts, modelled as discrete entities, and a continuous extracellular matrix composed of collagen and a fibrin based blood clot. There are four basic interactions assumed in the model: fibroblasts orient the collagen matrix, fibroblasts produce and degrade collagen and fibrin and the matrix directs the fibroblasts and determines the speed of the cells. Several factors which influence the alignment of collagen are examined and related to current anti-scarring therapies using transforming growth factor ß. The most influential of these factors are cell speed and, more importantly for wound healing, the influx of fibroblasts from surrounding tissue

Enhanced LANDSAT images of Antarctica and planetary exploration

Since early in the LANDSAT program, black-and-white paper prints of band 7 (near infrared) of the LANDSAT multispectral scanner have been used extensively to prepare semicontrolled maps of Antarctica. Image-processing techniques are now employed to enhance fine detail and to make controlled image-mosaic maps in color. LANDSAT multispectral images of Antarctica help to expand our knowledge of extraterrestrial bodies by showing bare-ice areas as bright blue patches; on such patches meteorites tend to be concentrated and are collected. Many subtle flow features in Antarctic ice streams resemble features at the mouths of Martian outflow channels, which suggests that the channels also contained ice. Furthermore, flow lines in Antarctic ice sheets that merge with ice shelves resemble Martian flow features associated with dissected terrain along the Martian northern highland margin, and support the concept that ice was involved in the transport of material from the southern highlands to the northern lowland plains. In Antarctica, as on Mars, the virtual absence of fluvial activity over millions of years has permitted the growth of glacial and eolian features to unusually large sizes

Capturing the time-varying drivers of an epidemic using stochastic dynamical systems

Epidemics are often modelled using non-linear dynamical systems observed through partial and noisy data. In this paper, we consider stochastic extensions in order to capture unknown influences (changing behaviors, public interventions, seasonal effects etc). These models assign diffusion processes to the time-varying parameters, and our inferential procedure is based on a suitably adjusted adaptive particle MCMC algorithm. The performance of the proposed computational methods is validated on simulated data and the adopted model is applied to the 2009 H1N1 pandemic in England. In addition to estimating the effective contact rate trajectories, the methodology is applied in real time to provide evidence in related public health decisions. Diffusion driven SEIR-type models with age structure are also introduced.Comment: 21 pages, 5 figure

Quiz Cube:an AR mobile learning application

The current paper presents the Quiz Cube application and its evaluation. The Quiz Cube application is an AR mobile learning application for students and teachers to easily make and use AR UI system using fiducial marker cubes. AR as a platform is just now reaching its full potential. Since smartphones and mobile devices are now at a sufficiently large user base, it is worth looking at the potential for an extremely small form factor delivery system that is flexible, easily modified, and used by educators and students. An easily modifiable AR learning experience will present an AR Mobile platform development, interactive museums, and the chosen subject in a new style. This method can be shown to improve not only knowledge of the chosen subject through investigation, but a better understanding of development potentials for the mobile devices now ubiquitous to students. The Quiz Cube application was evaluated in three different ways and the results are presented here

A Novel Sequence-Based Antigenic Distance Measure for H1N1, with Application to Vaccine Effectiveness and the Selection of Vaccine Strains

H1N1 influenza causes substantial seasonal illness and was the subtype of the 2009 influenza pandemic. Precise measures of antigenic distance between the vaccine and circulating virus strains help researchers design influenza vaccines with high vaccine effectiveness. We here introduce a sequence-based method to predict vaccine effectiveness in humans. Historical epidemiological data show that this sequence-based method is as predictive of vaccine effectiveness as hemagglutination inhibition (HI) assay data from ferret animal model studies. Interestingly, the expected vaccine effectiveness is greater against H1N1 than H3N2, suggesting a stronger immune response against H1N1 than H3N2. The evolution rate of hemagglutinin in H1N1 is also shown to be greater than that in H3N2, presumably due to greater immune selection pressure.Comment: 26 pages, 7 figures, 2 tables, supplemen

Laser Velocimeter Measurements in the Leakage Annulus of a Whirling Shrouded Centrifugal Pump

Previous experiments conducted in the Rotor Force Test Facility at the California Institute of Technology have thoroughly examined the effect of leakage flows on the rotordynamic forces on a centrifugal pump impeller undergoing a prescribed circular whirl. These leakage flows have been shown to contribute substantially to the total fluid induced forces acting on a pump. However, to date nothing is known of the flow field in the leakage annulus of shrouded centrifugal pumps. No attempt has been made to qualitatively or quantitatively examine the velocity field in the leakage annulus. Hence the test objective of this experiment is to acquire fluid velocity data for a geometry representative of the leakage annulus of a shrouded centrifugal pump while the rotor is whirling using laser velocimetry. Tests are performed over a range of whirl ratios and a flowrate typical of Space Shuttle Turbopump designs. In addition to a qualitive study of the flow field, the velocity data can be used to anchor flow models

On a model mechanism for the spatial patterning of teeth primordia in the Alligator

We propose a model mechanism for the initiation and spatial positioning of teeth primordia in the alligator,Alligator mississippiensis. Detailed embryological studies by Westergaard & Ferguson (1986, 1987, 1990) show that jaw growth plays a crucial role in the developmental patterning of the tooth initiation process. Based on biological data we develop a reaction-diffusion mechanism, which crucially includes domain growth. The model can reproduce the spatial pattern development of the first seven teeth primordia in the lower half jaw ofA. mississippiensis. The results for the precise spatio-temporal sequence compare well with detailed developmental experiments

Lexical Derivation of the PINT Taxonomy of Goals: Prominence, Inclusiveness, Negativity Prevention, and Tradition

What do people want? Few questions are more fundamental to psychological science than this. Yet, existing taxonomies disagree on both the number and content of goals. We thus adopted a lexical approach and investigated the structure of goal-relevant words from the natural English lexicon. Through an intensive rating process, 1,060 goal-relevant English words were first located. In Studies 1-2, two relatively large and diverse samples (total n = 1,026) rated their commitment to approaching or avoiding these goals. Principal component analyses yielded 4 replicable components: Prominence, Inclusiveness, Negativity prevention, and Tradition (the PINT Taxonomy). Study 3-7 (total n = 1,396) supported the 4-factor structure of an abbreviated scale and found systematic differences in their relationships with past goal-content measures, the Big 5 traits, affect, and need satisfaction. This investigation thus provides a data-driven taxonomy of higher-order goal-content and opens up a wide variety of fascinating lines for future research