A low-toxicity method for the separation of lanosterol and dihydrolanosterol from commercial mixtures

We describe an inexpensive, low-toxicity and high-yielding method for the production of pure lanosterol and dihydrolanosterol from the commercially available mixture. Optimum conditions are presented for the one-pot production of the intermediate 24,25 vicinal diol of lanosterol acetate (via either epoxidation or hydroxyhalogenation) which is readily separated from the unreacted dihydrolanosterol acetate. The lanosterol diol can then be converted to pure (>97%) lanosterol. Hypophosphorous acid was used for both the conversion of the epoxide to the diol, and as a catalyst for the hydroxyhalogenation by N-halosuccinimides of the olefinic bond

Efficient routes to epimerically-pure side-chain derivatives of lanosterol

A technically simple route is described to individual epimers of side-chain derivatives of lanosterol (3-hydroxy-5-lanosta-8,24-diene). Epimerically pure 24,25-epoxy-, 24,25-dihydroxy- and 24-bromo-25-hydroxy-lanosterol have been prepared in good yield from commercial (50-60%) lanosterol. Hypophosphorous acid was used as a catalyst for the cohalogenation of the 24(25) bond and also for the efficient conversion of 24,25-epoxy- and 24-bromo-25-hydroxylanosterol to epimerically pure 24(R) or 24(S)-24,25-dihydroxylanosterols

Weibel Instabilities in Dense Quantum Plasmas

The quantum effect on the Weibel instability in an unmagnetized plasma is presented. Our analysis shows that the quantum effect tends to stabilize the Weibel instability in the hydrodynamic regime, whereas it produces a new oscillatory instability in the kinetic regime. A novel effect the quantum damping, which is associated with the Landau damping, is disclosed. The new quantum Weibel instability may be responsible for the generation of non-stationary magnetic fields in compact astrophysical objects as well as in the forthcoming intense laser-solid density plasma experiments.Comment: Submitted to PR

On the nature of the short duration GRB 050906

The definitive version is available at www.blackwell-synergy.com. Copyright Blackwell Publishing DOI : 10.1111/j.1365-2966.2007.11953.xPeer reviewe

Chandra Observations of the X-ray Environs of SN 1998bw/GRB 980425

(Abrigded) We report X-ray studies of the environs of SN 1998bw and GRB 980425 using the Chandra X-Ray Observatory 1281 days after the GRB. Combining our observation of the supernova with others of the GRB afterglow, a smooth X-ray light curve, spanning ~1300 days, is obtained by assuming the burst and supernova were coincident at 35.6 Mpc. When this X-ray light curve is compared with those of the X-ray ``afterglows'' of ordinary GRBs, X-ray Flashes, and ordinary supernovae, evidence emerges for at least two classes of lightcurves, perhaps bounding a continuum. By three to ten years, all these phenomena seem to converge on a common X-ray luminosity, possibly indicative of the supernova underlying them all. This convergence strengthens the conclusion that SN 1998bw and GRB 980425 took place in the same object. One possible explanation for the two classes is a (nearly) standard GRB observed at different angles, in which case X-ray afterglows with intermediate luminosities should eventually be discovered. Finally, we comment on the contribution of GRB afterglows to the ULX source population.Comment: 26 pages, 5 figues, submitted to Ap

Understanding of the role of surveillance in Health Promotion for NCDs among Georgians

Background: Recognizing the need to build local capacity for non-communicable diseases (NCDs) and having a skilled workforce is an important strategy to implement the policy changes necessary to reduce the burden of NCDs. Indicators of tobacco smoking, alcohol consump on and drug abuse are s ll very high among Georgians. Nine out of ten deaths are a ributed to cardio-vascular diseases (CVD), cancer and injuries, the majority of which are caused by unhealthy behaviors. There is a very unclear understanding of health promo on (HP) approaches as a best opportunity to impact on NCDs and their risk factors even among Georgian professionals and more at the popula on level. The present study is the first effort to iden fy gaps, requirements and opportuni es in the health- promo on communica on system in Georgia, in order to iden fy the needs of capacity building for NCDs and their risk factors. Purpose: The Health Promo on Capacity Assessment aimed to evaluate the current health promo on system in Georgia. It covers the following issues: quality of health promo on/communica on and disease  preven on services, access to services, resources, health-promo on informa on/ communica on system and health-promo on financing. Its specific aims were (1) To iden fy the shor alls, requirements and opportuni es in health-promo on communica on through quan ta ve and qualita ve research; and (2) To define and analyze healthcare workers' knowledge, a tude and prac ce (KAP) related to health promo on/communica on aspects, the level of the professional development and requirements for their future training/retraining

The early and late-time spectral and temporal evolution of GRB 050716

We report on a comprehensive set of observations of Gamma Ray Burst 050716, detected by the Swift satellite and subsequently followed-up rapidly in X-ray, optical and near infra-red wavebands. The prompt emission is typical of long-duration bursts, with two peaks in a time interval of T90 = 68 seconds (15 - 350 keV). The prompt emission continues at lower flux levels in the X-ray band, where several smaller flares can be seen, on top of a decaying light curve that exhibits an apparent break around 220 seconds post trigger. This temporal break is roughly coincident with a spectral break. The latter can be related to the extrapolated evolution of the break energy in the prompt gamma-ray emission, and is possibly the manifestation of the peak flux break frequency of the internal shock passing through the observing band. A possible 3 sigma change in the X-ray absorption column is also seen during this time. The late-time afterglow behaviour is relatively standard, with an electron distribution power-law index of p = 2 there is no noticable temporal break out to at least 10 days. The broad-band optical/nIR to X-ray spectrum indicates a redshift of z ~> 2 for this burst, with a host-galaxy extinction value of E(B-V) ~ 0.7 that prefers an SMC-like extinction curve.Comment: Accepted to MNRAS. 8 pages, 5 figure