38 research outputs found

    Shared neural correlates for building phrases in signed and spoken language

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    Abstract Research on the mental representation of human language has convincingly shown that sign languages are structured similarly to spoken languages. However, whether the same neurobiology underlies the online construction of complex linguistic structures in sign and speech remains unknown. To investigate this question with maximally controlled stimuli, we studied the production of minimal two-word phrases in sign and speech. Signers and speakers viewed the same pictures during magnetoencephalography recording and named them with semantically identical expressions. For both signers and speakers, phrase building engaged left anterior temporal and ventromedial cortices with similar timing, despite different linguistic articulators. Thus the neurobiological similarity of sign and speech goes beyond gross measures such as lateralization: the same fronto-temporal network achieves the planning of structured linguistic expressions

    Анализ временных рядов кардиограмм для пациентов с нормальным ритмом сердца с помощью усредненных оценок смешанного момента и смешанного семиинварианта четвертого порядка

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    Работа посвящена применению усредненных оценок смешанного момента и смешанного семиинварианта 4-го порядка к анализу кардиологических временных рядов (R-R интервалов) для пациентов с нормальным ритмом сердца, с целью выявления скрытых периодов

    Characterization of Grafting Density and Binding Efficiency of DNA and Proteins on Gold Surfaces

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    The surface grafting density of biomolecules is an important factor for quantitative assays using a wide range of biological sensors. We use a fluorescent measurement technique to characterize the immobilization density of thiolated probe DNA on gold and hybridization efficiency of target DNA as a function of oligonucleotide length and salt concentration. The results indicate the dominance of osmotic and hydration forces in different regimes of salt concentration, which was used to validate previous simulations and to optimize the performance of surface-stress based microcantilever biosensors. The difference in hybridization density between complementary and mismatched target sequences was also measured to understand the response of these sensors in base-pair mismatch detection experiments. Finally, two different techniques for immobilizing proteins on gold were considered and the surface densities obtained in both cases were compared
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