Regularization and Anomalies in Gauge Theory

Some of the basic issues related to the regularization and anomalies in gauge theory are reviewed, with particular emphasis on the recent development in lattice gauge theory. The generalized Pauli-Villars regularization is discussed from a view point of the covariant regularization of currents, and the construction of a regularized effective action in terms of covariant currents is compared with the lattice formulation of chiral Abelian theory.Comment: 14 pages. Talk given at NATO Advanced Research Workshop ``Lattice Fermions and Structure of the Vacuum'', October 5-9, 1999, at Dubna, Russia (To be published in the Proceedings

The efficacy of halofantrine in the treatment of acute malaria in nonimmune travelers

A multicenter prospective trial was performed to investigate the efficacy and the tolerability of halofantrine in nonimmune patients with malaria imported from areas with drug-resistant falciparum parasites (mainly Africa). Forty-five of the 74 subjects were treated with a one-day regimen (3 x 500 mg) of halofantrine, and the other 29 received the same regimen with an additional treatment on day 7. In the second group, a 100% efficacy rate was demonstrated, but in the group receiving the one-day regimen, four recrudescences were observed in patients with falciparum malaria. Only five mild adverse reactions were seen, which disappeared spontaneously after the end of the treatment. We conclude that halofantrine is highly effective in curing malaria in nonimmune subjects. The treatment scheme for such persons should include an additional treatment on day 7 for nonimmune individuals. This drug was well tolerated in our patients, indicating that halofantrine will be useful in the treatment of multidrug-resistant malaria in nonimmune persons

Autochthonous European dirofilariasis of the lung

Two intrapulmonary round nodules were identified by x-ray examination in a 45-year old German woman during an examination conducted before her employment who had been complaining of pain in the right side of the thorax and of mild coughing irritation and tiredness for several months prior to the health check. Since the intraoperative frozen section did not show any malignancy, and atypical resection of the two involved segments was performed. Histological processing of the surgical specimens showed two spherical ischemic necroses surrounded by a connective tissue border with inflammatory infiltration. In the centre of the larger of the two necrotic lesions a parasite was seen intravascularly, which because of morphological and serological findings, was identified as a Dirofilaria. It must be assumed that the infection of this patient occurred during a stay in Corsica where these nematodes are endemic in several mammal hosts. The patient was therefore suffering from an autochthonous European dirofilariasis of the lung. Only two cases of this infection acquired in Europe have been reported so far

Lattice chiral symmetry, CP-violation and Majorana fermions

A brief summary of lattice fermions defined by the general Ginsparg-Wilson algebra is first given. It is then shown that those general class of fermion operators have a conflict with CP invariance in chiral gauge theory and with the definition of Majorana fermions in the presence of chiral-symmetric Yukawa couplings. The same conclusion holds for the domain-wall fermion also

Ordering monomial factors of polynomials in the product representation

The numerical construction of polynomials in the product representation (as used for instance in variants of the multiboson technique) can become problematic if rounding errors induce an imprecise or even unstable evaluation of the polynomial. We give criteria to quantify the effects of these rounding errors on the computation of polynomials approximating the function $1/s$. We consider polynomials both in a real variable $s$ and in a Hermitian matrix. By investigating several ordering schemes for the monomials of these polynomials, we finally demonstrate that there exist orderings of the monomials that keep rounding errors at a tolerable level.Comment: Latex2e file, 7 figures, 32 page

Nitrous oxide dynamics in low oxygen regions of the Pacific: insights from the MEMENTO database

The Eastern Tropical Pacific (ETP) is believed to be one of the largest marine sources of the greenhouse gas nitrous oxide N2O). Future N2Oemissions from the ETP are highly uncertain because oxygen minimum zones are expected to expand, affecting both regional production and consumption of N2O. Here we assess three primary uncertainties in how N2O may respond to changing O2 levels: (1) the relationship between N2O production and O2 (is it linear or exponential at low O2 concentrations?), (2) the cutoff point at which net N2O production switches to net N2O consumption (uncertainties in this parameterization can lead to differences in model ETP N2O concentrations of more than 20%), and (3) the rate of net N2O consumption at low O2. Based on the MEMENTO database, which is the largest N2O dataset currently available, we find that N2O production in the ETP increases linearly rather than exponentially with decreasing O2. Additionally, net N2O consumption switches to net N2O production at ~ 10 μM O2, a value in line with recent studies that suggest consumption occurs on a larger scale than previously thought. N2O consumption is on the order of 0.129 mmol N2O m−3 yr−1 in the Peru–Chile Undercurrent. Based on these findings, it appears that recent studies substantially overestimated N2O production in the ETP. In light of expected deoxygenation, future N2O production is still uncertain, but due to higher-than-expected consumption levels, it is possible that N2Oconcentrations may decrease rather than increase as oxygen minimum zones expand

Effective Field Theories

Effective field theories encode the predictions of a quantum field theory at low energy. The effective theory has a fairly low ultraviolet cutoff. As a result, loop corrections are small, at least if the effective action contains a term which is quadratic in the fields, and physical predictions can be read straight from the effective Lagrangean. Methods will be discussed how to compute an effective low energy action from a given fundamental action, either analytically or numerically, or by a combination of both methods. Basically,the idea is to integrate out the high frequency components of fields. This requires the choice of a "blockspin",i.e. the specification of a low frequency field as a function of the fundamental fields. These blockspins will be the fields of the effective field theory. The blockspin need not be a field of the same type as one of the fundamental fields, and it may be composite. Special features of blockspins in nonabelian gauge theories will be discussed in some detail. In analytical work and in multigrid updating schemes one needs interpolation kernels \A from coarse to fine grid in addition to the averaging kernels $C$ which determines the blockspin. A neural net strategy for finding optimal kernels is presented. Numerical methods are applicable to obtain actions of effective theories on lattices of finite volume. The constraint effective potential) is of particular interest. In a Higgs model it yields the free energy, considered as a function of a gauge covariant magnetization. Its shape determines the phase structure of the theory. Its loop expansion with and without gauge fields can be used to determine finite size corrections to numerical data.Comment: 45 pages, 9 figs., preprint DESY 92-070 (figs. 3-9 added in ps format

Louse-borne relapsing fever (Borrelia recurrentis) diagnosed in 15 refugees from northeast Africa: epidemiology and preventive control measures, Bavaria, Germany, July to October 2015

We report 15 imported louse-borne relapsing fever (LBRF) cases in refugees in Bavaria, Germany. One patient died. Epidemiological findings confirmed that all were young males from the Horn of Africa (12 from Somalia), who had similar migration routes converging in Sudan continuing through Libya and Italy. The majority likely acquired their infection during migration. Healthcare workers should be aware of LBRF in refugees passing through north Africa to ensure correct treatment and preventive measures.</jats:p

2015 ACVIM Small Animal Consensus Statement on Seizure Management in Dogs

This report represents a scientific and working clinical consensus statement on seizure management in dogs based on current literature and clinical expertise. The goal was to establish guidelines for a predetermined, concise, and logical sequential approach to chronic seizure management starting with seizure identification and diagnosis (not included in this report), reviewing decision‐making, treatment strategies, focusing on issues related to chronic antiepileptic drug treatment response and monitoring, and guidelines to enhance patient response and quality of life. Ultimately, we hope to provide a foundation for ongoing and future clinical epilepsy research in veterinary medicine

Proof-of-concept that network pharmacology is effective to modify development of acquired temporal lobe epilepsy

Epilepsy is a complex network phenomenon that, as yet, cannot be prevented or cured. We recently proposed network-based approaches to prevent epileptogenesis. For proof of concept we combined two drugs (levetiracetam and topiramate) for which in silico analysis of drug-protein interaction networks indicated a synergistic effect on a large functional network of epilepsy-relevant proteins. Using the intrahippocampal kainate mouse model of temporal lobe epilepsy, the drug combination was administered during the latent period before onset of spontaneous recurrent seizures (SRS). When SRS were periodically recorded by video-EEG monitoring after termination of treatment, a significant decrease in incidence and frequency of SRS was determined, indicating antiepileptogenic efficacy. Such efficacy was not observed following single drug treatment. Furthermore, a combination of levetiracetam and phenobarbital, for which in silico analysis of drug-protein interaction networks did not indicate any significant drug-drug interaction, was not effective to modify development of epilepsy. Surprisingly, the promising antiepileptogenic effect of the levetiracetam/topiramate combination was obtained in the absence of any significant neuroprotective or anti-inflammatory effects as indicated by multimodal brain imaging and histopathology. High throughput RNA-sequencing (RNA-seq) of the ipsilateral hippocampus of mice treated with the levetiracetam/topiramate combination showed that several genes that have been linked previously to epileptogenesis, were significantly differentially expressed, providing interesting entry points for future mechanistic studies. Overall, we have discovered a novel combination treatment with promise for prevention of epilepsy