Evaluation of effect of the primary particle size on compactibility of spray-dried lactoses

Spray-dried lactose is one of the most used filler-binders in direct compaction of tablets. Spray-dried lactose is produced by spray-drying a suspension of α-lactose monohydrate crystals in a saturated aqueous solution of lactoses. The resulting product is composed of spherical particles, containing 80-85% crystals of α-lactose monohydrate (primary particles) and 15-20% amorphous lactose The compactibility of two commercial spray-dried lactoses, Pharmatose® DCL 11 (DCL11), prepared from α-lactose monohydrate with a median primary particle size of 34 µm and a new product, Pharmatose® DCL 14 (DCL14), prepared from 20 µm primary particles, were investigated

EFFECT OF DEHYDRATION ON THE BINDING-CAPACITY OF PARTICULATE HYDRATES

The binding capacities of alpha-D-glucose dehydrated at temperatures from 60-135 degrees C increased with increasing temperature of dehydration

Studies on tableting properties of lactose: VIII. The effect of variations in primary particle size, percentage of amorphous lactose and addition of a disintegrant on the disintegration of spray-dried lactose tablets

Disintegration of tablets compacted from spray-dried lactose samples was found to depend on the amount of amorphous lactose, the size of the primary particles and the compaction load, respectively. The poor disintegration properties of amorphous lactose was explained by pointing to the dissolution characteristics of the substance. Considerable improvement of the disintegration properties can be obtained by addition of suitable disintegrant