Spray-dried lactose is one of the most used filler-binders in direct compaction of tablets.
Spray-dried lactose is produced by spray-drying a suspension of α-lactose monohydrate
crystals in a saturated aqueous solution of lactoses. The resulting product is composed of
spherical particles, containing 80-85% crystals of α-lactose monohydrate (primary particles) and 15-20% amorphous lactose
The compactibility of two commercial spray-dried lactoses, Pharmatose® DCL 11
(DCL11), prepared from α-lactose monohydrate with a median primary particle size of 34
µm and a new product, Pharmatose® DCL 14 (DCL14), prepared from 20 µm primary
particles, were investigated
